1. IGF-1 and its binding proteins IGFBP-1 and 3 as nutritional markers in prepubertal children.
- Author
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Martínez de Icaya P, Fernández C, Vázquez C, del Olmo D, Alcázar V, and Hernández M
- Subjects
- Biomarkers analysis, Body Mass Index, Child, Cross-Sectional Studies, Female, Humans, Male, Radioimmunoassay, Reproducibility of Results, Serum Albumin analysis, Spain, Surveys and Questionnaires, Transferrin analysis, Body Weight, Insulin-Like Growth Factor Binding Protein 1 analysis, Insulin-Like Growth Factor Binding Protein 3 analysis, Insulin-Like Growth Factor I analysis, Nutritional Status
- Abstract
Objective: To assess the validity of the use of IGF-1, IGFBP-1 and IGFBP-3 as biochemical markers of nutritional status in prepubertal healthy children., Design: Cross-sectional survey., Setting: Healthy children from the Madrid area., Participants: Prepubertal children (aged 7-10 years) with a body mass index (BMI) above the 90th percentile (n = 25) and below the 10th percentile (n = 31) were selected from 2,559 included in the CAENPE study (Food Intake and Nutritional Status in Schoolchildren from Madrid)., Results: Overweight children were found to have higher serum levels of IGF-1 (306+/-162.2 vs. 209+/-71.2 ng/ml, p<0.001) and IGFBP-3 (3.3+/-1.0 vs. 2.9+/- 0.5 mg/l, p<0.01) and lower serum levels of IGFBP-1 (4.3+/-3.9 vs. 13.8+/-7.4 microg/l, p<0.01). There was a positive correlation with BMI, for IGF-1 and IGFBP-3, and negative correlation for IGFBP-1. No differences in albumin and transferrin concentrations were observed between both groups of children., Conclusion: IGF-1, IGFBP-1 and IGFBP-3 clearly classify over- and underweight prepubertal children, showing a good correlation with BMI. They can be used as biochemical markers of caloric nutritional status in this population.
- Published
- 2000
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