1. Risk of Posterior Capsular Rupture during Phacoemulsification in Patients with the History of Anti-VEGF Intravitreal Injections: Results from the Pan-American Collaborative Retina Study (PACORES) Group.
- Author
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Velez-Montoya, Raul, Sanchez-Santos, Idaira, Galvan-Chavez, Mauricio, Wu, Lihteh, Arevalo, J. Fernando, Berrocal, María H., Alezzandrini, Arturo A., Figueroa, Marta S., Gallego-Pinazo, Roberto, Dolz-Marco, Rosa, Martinez-Rubio, Clara, and Gonzalez-Salinas, Roberto
- Subjects
SURGICAL complication risk factors ,VASCULAR endothelial growth factor antagonists ,PHACOEMULSIFICATION ,HOSPITALS ,STATISTICS ,INJECTIONS ,ACQUISITION of data methodology ,CONFIDENCE intervals ,WORK ,MULTIVARIATE analysis ,PHYSICIANS' attitudes ,OCULAR injuries ,RISK assessment ,MEDICAL records ,EXPERIENTIAL learning ,DISEASE prevalence ,DESCRIPTIVE statistics ,ODDS ratio ,DISEASE risk factors - Abstract
Purpose. To assess the risk for capsular rupture during routine phacoemulsification in patients with a history of anti-VEGF injections and other possible risk modifiers such as treatment patterns, type of anti-VEGF agent, and experience of the surgeon, among others. Methods. This study reviewed the medical records of 11,129 patients from 7 different hospitals in 5 countries. The study included 939 patients that underwent routine phacoemulsification and had a history of anti-VEGF therapy. We excluded patients with known risk factors for capsular rupture, as well as patients with a history of other retinal procedures. The study extracted data regarding general demographics, the number of previous injections, type of anti-VEGF agent, details of cataract surgery, and anti-VEGF treatment patterns. Results. Overall prevalence of posterior capsular rupture: 7.45% (95% CI: 5.9–9.32%). The mean number of injections per patient was 3.37 ± 2.8. More than 50% of the patients received their last anti-VEGF injection within three months before cataract surgery. The complication rate during intravitreal injections was 1.07%. In the univariate analysis, the experience of the cataract surgeon (inexperience surgeons; OR: 2.93) and the history of prior anti-VEGF therapy (OR: 1.77) were significant risk indicators for PCR (p < 0.05). However, after controlling for age in the multivariate analysis, the trend did not reach a statistical significance. Conclusion. The risk for capsular rupture is higher in patients with a history of intravitreal anti-VEGF injections. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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