1. Search for antiviral activity in higher plant extracts.
- Author
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Abad MJ, Guerra JA, Bermejo P, Irurzun A, and Carrasco L
- Subjects
- Antiviral Agents isolation & purification, Cytopathogenic Effect, Viral, HeLa Cells, Herpesvirus 1, Human drug effects, Herpesvirus 1, Human growth & development, Humans, Poliovirus drug effects, Poliovirus growth & development, Scintillation Counting, Spain, Sulfur Radioisotopes, Vesicular stomatitis Indiana virus drug effects, Vesicular stomatitis Indiana virus growth & development, Antiviral Agents pharmacology, Plant Extracts pharmacology, Plants, Medicinal chemistry
- Abstract
In the course of our search for plant natural products as antiviral agents, extracts of ten plants from the Iberian Peninsula were tested for antiviral activity against herpes simplex type I (HSV-1), vesicular stomatitis virus (VSV) and poliovirus type 1. Aqueous extracts of five of these medicinal plants, namely Nepeta nepetella (150-500 microg/mL), Nepeta coerulea (150-500 microg/mL), Nepeta tuberosa (150-500 microg/mL), Dittrichia viscosa (50-125 microg/mL) and Sanguisorba minor magnolii (50-125 microg/mL), showed a clear antiviral activity against two different DNA and RNA viruses, i.e. HSV-1 and VSV. Only the medicinal plant Dittrichia viscosa was active against an additional virus, poliovirus type 1.
- Published
- 2000
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