1. Immune checkpoint B7-H3 protein expression is associated with poor outcome and androgen receptor status in prostate cancer.
- Author
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Nunes-Xavier CE, Kildal W, Kleppe A, Danielsen HE, Waehre H, Llarena R, Maelandsmo GM, Fodstad Ø, Pulido R, and López JI
- Subjects
- Aged, B7 Antigens genetics, Biomarkers, Tumor genetics, Cohort Studies, Databases, Genetic trends, Follow-Up Studies, Humans, Immune Checkpoint Proteins genetics, Male, Middle Aged, Norway epidemiology, Prostatic Neoplasms diagnosis, Prostatic Neoplasms epidemiology, Receptors, Androgen genetics, Spain epidemiology, Treatment Outcome, B7 Antigens biosynthesis, Biomarkers, Tumor biosynthesis, Gene Expression Regulation, Neoplastic physiology, Immune Checkpoint Proteins biosynthesis, Prostatic Neoplasms metabolism, Receptors, Androgen biosynthesis
- Abstract
Background: Novel immune checkpoint-based immunotherapies may benefit specific groups of prostate cancer patients who are resistant to other treatments., Methods: We analyzed by immunohistochemistry the expression of B7-H3, PD-L1/B7-H1, and androgen receptor (AR) in tissue samples from 120 prostate adenocarcinoma patients treated with radical prostatectomy in Spain, and from 206 prostate adenocarcinoma patients treated with radical prostatectomy in Norway., Results: B7-H3 expression correlated positively with AR expression and was associated with biochemical recurrence in the Spanish cohort, but PD-L1 expression correlated with neither of them. Findings for B7-H3 were validated in the Norwegian cohort, where B7-H3 expression correlated positively with Gleason grade, surgical margins, seminal vesicle invasion, and CAPRA-S risk group, and was associated with clinical recurrence. High B7-H3 expression in the Norwegian cohort was also consistent with positive AR expression., Conclusion: These results suggest distinct clinical relevance of the two immune checkpoint proteins PD-L1 and B7-H3 in prostate cancer. Our findings highlight B7-H3 as an actionable novel immune checkpoint protein in prostate cancer., (© 2021 The Authors. The Prostate published by Wiley Periodicals LLC.)
- Published
- 2021
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