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The implementation of evidence-based psychological programming to meet the needs of a global population has been impeded by the translation of theories and research findings across populations and settings without due consideration of cultural factors. The purpose of this article is to discuss the rationale for use of partnership-based methods in the development of culturally constructed school mental health programming. We describe the application of such approaches to two diverse populations. We conclude with a discussion of future research examining the application of partnership-based approaches to the development of culturally informed psychological programming across global settings.