1. Alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata WIGHT).
- Author
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Ozaki S, Oe H, and Kitamura S
- Subjects
- Animals, Heterocyclic Compounds, 1-Ring chemistry, Intestine, Small enzymology, Molecular Structure, Monosaccharides chemistry, Monosaccharides isolation & purification, Pancreas enzymology, Rats, Sri Lanka, Sucrase drug effects, Sugar Alcohols chemistry, Sugar Alcohols isolation & purification, Sulfates chemistry, Sulfates isolation & purification, Sulfur Compounds chemistry, Swine, alpha-Amylases antagonists & inhibitors, alpha-Glucosidases drug effects, Glycoside Hydrolase Inhibitors, Heterocyclic Compounds, 1-Ring isolation & purification, Heterocyclic Compounds, 1-Ring pharmacology, Plants, Medicinal chemistry, Salacia chemistry, Sulfur Compounds isolation & purification, Sulfur Compounds pharmacology
- Abstract
A polyhydroxylated cyclic 13-membered sulfoxide (1) was isolated from an aqueous extract of Kothala-himbutu ( Salacia reticulata WIGHT). The structure of compound 1 was elucidated by 1D and 2D NMR and APCI-MS methods. The alpha-glucosidase inhibitory activity of compound 1 (IC 50: maltase, 0.227 microM; sucrase, 0.186 microM; isomaltase, 0.099 microM) was much greater than the inhibitory activity of salacinol and kotalanol, which were previously isolated from Kothala-himbutu.
- Published
- 2008
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