1. Well-Tolerated Chemoprophylaxis Uniformly Prevented Swedish Soldiers from Plasmodium falciparum Malaria in Liberia, 2004-2006.
- Author
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Andersson, Håkan, Askling, Helena H., Falck, Björn, and Rombo, Lars
- Subjects
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PLASMODIUM falciparum , *MALARIA , *CHEMOPREVENTION , *MEFLOQUINE - Abstract
Background: Between 2004 and 2006, 1,170 Swedish soldiers were deployed to Liberia. They were prescribed mefloquine or atovaquone/proguanil as malaria chemoprophylaxis. Our study aims were to estimate the chemoprophylaxis effectiveness and adverse events. Methods: Cases or malaria were routinely reported during and after the mission. After return to Sweden. the soldiers filled in a questionnaire concerning type of accommodation, use of prophylaxis, and adverse events. Results: No cases of Plasmodium falciparum malaria were recorded during a total of -7,000 person-months, Adverse events (AE) were reported by 57% in the mefloquine group and 34% in the atovaquone/proguanil group. In the mefloquine group, the soldiers reported more neuropsychological AE. Conclusions: Both drugs were sate and 100% effective as long-term prophylaxis far prevention of P. falciparum malaria, Atovaquone/ proguanil was better tolerated with respect to serf-reported AE. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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