1. Multidrug-resistant pneumococci (serotype 8) causing invasive disease in HIV+ patients.
- Author
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Sanz JC, Cercenado E, Marín M, Ramos B, Ardanuy C, Rodríguez-Avial I, and Bouza E
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Electrophoresis, Gel, Pulsed-Field, Female, Humans, Infant, Male, Microbial Sensitivity Tests, Middle Aged, Multilocus Sequence Typing, Prevalence, Serotyping, Streptococcus pneumoniae isolation & purification, Sweden epidemiology, Young Adult, Anti-Bacterial Agents pharmacology, Drug Resistance, Multiple, Bacterial, HIV Infections complications, Pneumococcal Infections epidemiology, Pneumococcal Infections microbiology, Streptococcus pneumoniae classification, Streptococcus pneumoniae drug effects
- Abstract
From July 2007 to June 2009, all pneumococci causing invasive pneumococcal disease in our hospital were serotyped. Antimicrobial susceptibility was determined by microdilution. Molecular typing was performed by pulsed-field gel electrophoresis and by multilocus sequence typing. Among 251 invasive pneumococci, serotype 8 was the most frequent (13.5%). All serotype 8 strains were susceptible to penicillin; however, 61.8% (21/34) were co-resistant to erythromycin, levofloxacin and tetracycline and identical to the Sweden(15A) -ST63 clone. Serotype 8 was significantly more frequent among human immunodeficiency virus (HIV)-infected patients (36.5%). The high prevalence of this non-conjugate vaccine multiresistant serotype 8 is a cause for concern mainly in HIV-infected patients., (© 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.)
- Published
- 2011
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