1. DNA and cell cycle analysis as prognostic indicators in breast tumors revisited.
- Author
-
Bagwell CB, Clark GM, Spyratos F, Chassevent A, Bendahl PO, Stål O, Killander D, Jourdan ML, Romain S, Hunsberger B, Wright S, and Baldetorp B
- Subjects
- Breast Neoplasms genetics, Breast Neoplasms mortality, Disease-Free Survival, Female, France epidemiology, Humans, Ploidies, Prognosis, Sweden epidemiology, Breast Neoplasms pathology, Cell Cycle physiology, DNA, Neoplasm analysis, Flow Cytometry methods
- Abstract
Both DNA ploidy and S-phase ploidy are promising prognostic factors for node-negative breast cancer patients. Based largely on the analysis of one large study, much of the reported problems with these factors have been caused by some unappreciated complexities in categorizing DNA ploidy into low- and high-risk groups and the lack of some necessary adjustments to eliminate unwanted correlations between DNA S-phase and ploidy. When both DNA ploidy and S-phase are compensated properly, they become independent prognostic markers, forming a powerful prognostic model.
- Published
- 2001