1. Overall assessment of tumor-infiltrating lymphocytes in head and neck squamous cell carcinoma: time to take notice.
- Author
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Almangush, Alhadi, Leivo, Ilmo, and Mäkitie, Antti A.
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CONFERENCES & conventions , *IMMUNOTHERAPY , *LYMPHOCYTES , *HEAD & neck cancer , *SQUAMOUS cell carcinoma , *STAINS & staining (Microscopy) - Abstract
Background: The immune response has an important role in cancer progression. At the same time, anti-tumor effect of the immune response has been speculated to cause destruction of cancer cells. Recent studies have highlighted the significance of tumor-infiltrating lymphocytes (TILs) in different cancers. The International Immuno-Oncology Biomarkers Working Group has in 2017 published a practical review proposing a standardized method to assess TILs in the routine hematoxylin and eosin (HE) stained sections. Aims/objectives: To discuss the association between TILs and survival in head and neck squamous cell carcinoma (HNSCC). Material and methods: We review recent studies having assessed TILs in HNSCC and showing that tumors having low TILs associate significantly with worse survival. Results: These findings underline that HNSCC cases with low TILs might benefit from multimodality treatment and might be indicated to receive immunotherapy. Conclusions: The evaluation of TILs using routine HE-stained sections is practical and can be considered in assessment of antitumor activity. Significance: Here, we highlight the impact of overall assessment of TILs using the routine HE-stained specimens in HNSCC. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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