1. Impact of Endothelial Shear Stress on Absorption Process of Resorbable Magnesium Scaffold: A BIOSOLVE-II Substudy.
- Author
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Ozaki, Yuichi, Kuku, Kayode O., Sakellarios, Antonis, Haude, Michael, Hideo-Kajita, Alexandre, Desale, Sameer, Siogkas, Panagiotis, Sioros, Spyros, Ince, Hüseyin, Abizaid, Alexandre, Tölg, Ralph, Lemos, Pedro Alves, von Birgelen, Clemens, Christiansen, Evald Høj, Wijns, William, Escaned, Javier, Michalis, Lampros, Fotiadis, Dimitrios I., Djikstra, Jouke, and Waksman, Ron
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SHEARING force , *OPTICAL coherence tomography , *ABSORPTION , *MAGNESIUM , *CORONARY artery surgery , *PROSTHETICS , *MEDICAL care , *CARDIOVASCULAR system , *TREATMENT effectiveness , *CORONARY angiography , *CORONARY artery disease , *DRUGS , *CORONARY arteries - Abstract
Background/purpose: Local hemodynamic forces such as endothelial shear stress (ESS) may have an influence on appropriate neointimal healing, vessel remodeling, and struts' absorption process following second-generation drug-eluting resorbable magnesium scaffold (RMS, Magmaris, Biotronik AG, Buelach, Switzerland) placement. The aim of this study was to investigate the impact of ESS assessed by optical coherence tomography (OCT)-based computational fluid dynamic (CFD) simulations on absorption process and coronary lumen dimension after Magmaris implantation.Methods and Results: A total of 22 patients who were enrolled in the BIOSOLVE-II trial and underwent serial OCT assessment immediately after Magmaris implantation and at 6- and 12-month follow-up were included. We evaluated qualitative OCT findings frame by frame, and CFD simulations were performed to calculate the ESS at 3-dimensional (3D) reconstructed arteries. For quantitative calculation, the average ESS within each 1-mm section was classified into three groups: low (<1.0 Pa), intermediate (1.0-2.5 Pa), or high (>2.5 Pa). A significant difference of percentage remnants of scaffold was observed among the 3 groups at 12-month follow-up (P = 0.001) but not at 6-month follow-up. Low-ESS segment at baseline resulted in a greater lumen change of -1.857 ± 1.902 mm2 at 1 year compared to -1.277 ± 1.562 mm2 in the intermediate-ESS segment (P = 0.017) and - 0.709 ± 1.213 mm2 in the high-ESS segment (P = 0.001).Conclusion: After Magmaris implantation, the presence of higher ESS might be associated with slower strut absorption process but less luminal loss. [ABSTRACT FROM AUTHOR]- Published
- 2021
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