Competing Interests: Competing interests: AR-W reports grants and personal fees from Abbvie, grants and personal fees from Pfizer, personal fees from USB, personal fees from MSD, personal fees from Roche-Chugai, personal fees from Sanofi-Aventis, personal fees from Gilead, personal fees from Mylan, personal fees from Fresenius Kabi, personal fees from Sandoz, personal fees from Amgen, personal fees from Novartis, personal fees from Lilly, personal fees from BMS, outside the submitted work. M-ET reports personal fees from Pfizer, personal fees from Abbvie, personal fees from UCB, outside the submitted work; AB reports personal fees from UCB, personal fees from LILLY, personal fees from ABBVIE, personal fees from BMS, personal fees from JANSSEN, personal fees from MSD, personal fees from NOVARTIS, during the conduct of the study. RS reports non-financial support and other from amgen, other from fresenius kabi, other from pfizer, other from roche, other from lilly, non-financial support and other from gsk, other from bms, outside the submitted work.