1. Saitohin gene is not associated with Alzheimer's disease.
- Author
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Streffer, J. R., Papassotiropoulos, A., Kurosinski, P., Signorell, A., Wollmer, M. A., Tsolaki, M., Lakovidou, V., Hörndli, F., Bosset, J., Götz, J., Nitsch, R. M., Hock, C., Iakovidou, V, Hörndli, F, and Götz, J
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ALZHEIMER'S disease , *WHITE people , *NEURODEGENERATION , *GENETIC polymorphisms , *PRESENILE dementia , *SENILE dementia - Abstract
Background: The deposition of tau protein in neurofibrillary tangles constitutes an important feature of many neurodegenerative disorders, including Alzheimer's disease. A polymorphic gene, saitohin (STH), nested within the tau gene (microtubule associated protein tau, MAPT), was recently identified and an association of a non-synonymous polymorphism in STH with increased risk for Alzheimer's disease was suggested.Objective and Methods: To test the above hypothesis in a case-control association study of two independent white populations within Switzerland and Greece, comparing genotype and allele frequencies from 225 Alzheimer's disease patients and 144 healthy control subjects.Results: No differences in allelic or genotypic distributions between Alzheimer's disease patients and controls was found in the individual samples (Swiss/Greek) or in the combined sample. Stratification for the presence of apolipoprotein E (APOE) epsilon 4 allele, sex, or age did not show significant effects in the populations studied, nor was there an effect on the age of onset.Conclusions: No evidence was found for an association of the non-synonymous polymorphism (Q7R) in STH and Alzheimer's disease. This finding is in line with earlier studies showing no association between MAPT and Alzheimer's disease. [ABSTRACT FROM AUTHOR]- Published
- 2003
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