1. Serum E-selectin concentration is associated with risk of metabolic syndrome in females.
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Lee, Chien-Hsing, Kuo, Feng-Chih, Tang, Wen-Hao, Lu, Chieh-Hua, Su, Sheng-Chiang, Liu, Jhih-Syuan, Hsieh, Chang-Hsun, Hung, Yi-Jen, and Lin, Fu-Huang
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METABOLIC syndrome ,SYSTOLIC blood pressure ,WAIST-hip ratio ,ENDOTHELIUM diseases ,FEMALES - Abstract
Objectives: Traits of metabolic syndrome (MetS) and biomarkers of inflammation and endothelial dysfunction were examined. We investigated the differences of various biomarkers among individuals with or without Mets in a gender-specific manner. The gender-specific associations between E-selectin and MetS were further evaluated. Methods: A total of 205 patients were recruited from the outpatient clinics of Tri-Service General Hospital, Taipei, Taiwan. Inclusion criteria were age between 20–75 years and BMI < 35 kg/m
2 . Demographic, anthropometric and MetS index data were compared between genders. Markers of inflammation and endothelial dysfunction were compared between individuals with or without MetS by gender. Results: Age-adjusted E-selectin values showed significant positive correlations with BMI, waist-hip ratio, fasting plasma glucose, systolic and diastolic blood pressure, triglycerides, TNF-α, hsCRP and ICAM-1, and inverse correlation with HDL cholesterol. E-selectin levels were positively correlated with numbers of MetS components in females (P < 0.001) but not in males (P = 0.125). Conclusions: Increased E-selectin levels are significantly associated with increased MetS risk in females, but not in males. [ABSTRACT FROM AUTHOR]- Published
- 2019
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