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With the transfer or abolishment of industrial production activities, the abandoned industrial buildings and affiliated facilities have become precious industrial heritages in modern cities. As the witnesses of human civilization and urban development, the industrial heritages have become essential media of human history and cultural landscapes To achieve the remodeling and regeneration of urban industrial landscapes via protecting and reutilizing industrial heritage has already become a significant content of modern urban renewal and a new topic of urban development Taking relevant concepts, key points and practices of remodeling and regeneration of urban industrial landscapes as the theoretical basis, and Huashan 1914 Creative Park for example, this paper explored the remodeling and regeneration of modern urban industrial landscapes. [ABSTRACT FROM AUTHOR]

Left Ventricular Remodeling in Pacing Dogs. Introduction: Right ventricle (RV) apical pacing is associated with increased incidence of heart failure due to left ventricle (LV) desynchronization. We aim to investigate extracellular matrix (ECM) remodeling of the LV in dogs with atria-sensed RV apical pacing. Methods and Results: Dogs with pacemakers underwent AV nodal ablation. After 12 weeks of atria-sensed obligatory RV pacing, LVs were separated into septum and lateral wall for analysis. Zymographic activity, including matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitors of metalloproteinase-1 (TIMP-1), TIMP-3, collagen transcript expression, and histology were examined in opposite portions of the LV to identify possible ECM remodeling changes by RV apical pacing. Compared with sham-operated dogs, increased interstitial fibrosis and fragmentation of myofibrils was found in the LV lateral wall in the pacing group. Collagen type II mRNA showed a significant 2-fold increase in the LV lateral wall in the pacing group. Although collagen type I mRNA was increased, the difference was not significant. Zymography demonstrated MMP-9 activity was enhanced in both the LV lateral wall and septum in the pacing group, but MMP-2 activity was enhanced in the LV lateral wall. Immunfluorescence stain confirmed the activation of MMP-2 and MMP-9 in the LV lateral wall in the pacing group. Protein expression of TIMP-1 and TIMP-3 showed regional differences in the pacing group and both proteins were increased in the LV lateral wall. Conclusion: LV dyssynchrony by RV apical pacing elicits heterogeneous ECM remodeling in the LV. These findings assist in the elucidation of the pathophysiology of LV desynchronization. (J Cardiovasc Electrophysiol, Vol. 21, pp. 1142-1149) [ABSTRACT FROM AUTHOR]

SUMMARY: Background: Left ventricular (LV) remodeling has been shown to impart prognostic significance in previous studies. However, the underlying exact mechanisms involved and interactions between LV geometry alterations and age with other clinical and biochemical variables in general population have not been well established. Methods: A total of 406 consecutive subjects were enrolled in a health evaluation center-based population study (mean age, 51.5 ± 10.9 years; 42% women). Data including baseline characteristics, echocardiography, biochemistry and biomarkers were all collected and evaluated. Univariate and multivariate regression analysis was performed to test the relationship between relative wall thickness (RWT) and other variables. We also divided the subjects into older and younger groups, compared RWT between the two groups, and analyzed the distribution of LV geometry in these groups. Results: The prevalence of diabetes and hypertension in our study population was relatively small (11.6% and 16.5%, respectively). The most common type of LV geometry in our study was normal (67.5%) and concentric remodeling (30.3%) compared with a relatively small proportion of concentric LV hypertrophy (1.5%) and eccentric hypertrophy (< 1%). Of all 406 subjects evaluated, age, uric acid, height, systolic blood pressure and serum insulin level were all independent factors associated with RWT in a multivariate regression model. Conclusion: In our study, we revealed that aging, together with baseline blood pressure and serum biochemistries, were associated with LV geometric alterations. These data suggest that the LV remodeling process actually involves dynamic and complex interactions with multiple metabolic factors in an unselected general population in Taiwan. [Copyright &y& Elsevier]