9 results on '"Wang, Li-Yun"'
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2. Higher Education Institutional and Program Evaluations in Taiwan and the Emerging Roles of Higher Education Evaluation and Accreditation Council of Taiwan (HEEACT)
- Author
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Lee, Lung-Sheng, Wei, Yen-Shun, and Wang, Li-Yun
- Abstract
Post-secondary education institutions in Taiwan are divided into two tracks, general higher education (HE) and technological and vocational education (TVE). The evaluation of all universities/colleges is mandated by the University Act. Higher education institutions receive mandated institutional evaluation every six years and program evaluation every five years. The purpose of this paper is to briefly introduce the status of higher education institutional and program evaluations in Taiwan as well as the emerging roles of the Higher Education Evaluation and Accreditation Council of Taiwan (HEEACT). Both institutional and program evaluations are accreditation-oriented, adopting the PDCA (Plan-Do-Check-Act) cycle with an emphasis on institutional and program self-positioning, student learning outcome, and mechanism for continuous improvement. As the third-party planner and implementer of higher education institutional and program evaluations, HEEACT has conducted internal and external assessments as well as entrusted third-party meta-evaluation to assure its quality of work. Faced with the emerging challenges, such as the Ministry of Education's new policy on requiring some universities/colleges to implement self-conducted external evaluation in replacement of the third-party program evaluation, HEEACT has to alter its roles and becomes a Critical Friend of higher education institutions and programs, a Change Agent of higher education institutional and program evaluation, and an Effective Facilitator of the international exchanges and cooperation on quality assurance and mutual recognitions of national qualifications. (Contains 3 figures.)
- Published
- 2013
3. Higher Educational Expansion in Taiwan from 1950 to 1994: Patterns and Explanations. ASHE Annual Meeting Paper.
- Author
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Wang, Li-yun
- Abstract
This paper examines the expansion of higher education in Taiwan from 1950 to 1994, looking first at the patterns of the expansion and, secondly, attempting to account for these patterns. Higher education in Taiwan is defined as general universities and colleges, institutes of technology, and junior colleges with governance of the system under the control of the Ministry of Education. The study reviewed major historical events and examined documents and the literature concerning patterns of expansion in the number of institutions, in the number of students enrolled, and in expenditures. The study then reviewed the state's stated reasons--economic concerns, educational quality, social demands, and equal distribution of resources--for regulating expansion of higher education, and compared these reasons with other models of educational expansion and with the actual results achieved. The paper concludes by taking issue with the state's official position and suggests that the primary reason for its controlling growth was to keep unemployment rates among college graduates low. Further studies to examine educational policy making and educational supply and demand models are suggested. Appendices illustrate the structure of the Taiwan school system, list historical events related to higher educational expansion, list official documents reviewed, and provide graphical displays of trend data. (Contains approximately 100 references.) (CH)
- Published
- 1996
4. Updated Confirmatory Diagnosis for Mucopolysaccharidoses in Taiwanese Infants and the Application of Gene Variants.
- Author
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Chuang, Chih-Kuang, Tu, Yuan-Rong, Lee, Chung-Lin, Lo, Yun-Ting, Chang, Ya-Hui, Liu, Mei-Ying, Liu, Hsin-Yun, Chen, Hsiao-Jan, Kao, Shu-Min, Wang, Li-Yun, Ho, Huey-Jane, Lin, Hsiang-Yu, and Lin, Shuan-Pei
- Subjects
GLYCOSAMINOGLYCANS ,GENETIC variation ,TANDEM mass spectrometry ,INFANTS ,LYSOSOMES ,LYSOSOMAL storage diseases ,DERMATAN sulfate - Abstract
Mucopolysaccharidosis (MPS) is a lysosomal storage disease caused by genetic defects that result in deficiency of one specific enzyme activity, consequently impairing the stepwise degradation of glycosaminoglycans (GAGs). Except for MPS II, the other types of MPS have autosomal recessive inheritance in which two copies of an abnormal allele must be present in order for the disease to develop. In this study, we present the status of variant alleles and biochemistry results found in infants suspected of having MPS I, II, IVA, and VI. A total of 324 suspected infants, including 12 for MPS I, 223 for MPS II, 72 for MPS IVA, and 17 for MPS VI, who were referred for MPS confirmation from newborn screening centers in Taiwan, were enrolled. In all of these infants, one specific enzyme activity in dried blood spot filter paper was lower than the cut-off value in the first blood sample, as well asin a second follow-up sample. The confirmatory methods used in this study included Sanger sequencing, next-generation sequencing, leukocyte enzyme fluorometric assay, and GAG-derived disaccharides in urine using tandem mass spectrometry assays. The results showed that five, nine, and six infants had MPS I, II, and IVA, respectively, and all of them were asymptomatic. Thus, a laboratory diagnosis is extremely important to confirm the diagnosis of MPS. The other infants with identified nucleotide variations and reductions in leukocyte enzyme activities were categorized as being highly suspected cases requiring long-term and intensive follow-up examinations. In summary, the final confirmation of MPS depends on the most powerful biomarkers found in urine, i.e., the quantification of GAG-derived disaccharides including dermatan sulfate, heparan sulfate, and keratan sulfate, and analysis of genetic variants can help predict outcomes and guide treatment. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
- View/download PDF
5. Newborn Screening Program for Mucopolysaccharidosis Type II and Long-Term Follow-Up of the Screen-Positive Subjects in Taiwan.
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Lin, Hsiang-Yu, Chang, Ya-Hui, Lee, Chung-Lin, Tu, Yuan-Rong, Lo, Yun-Ting, Hung, Pei-Wen, Niu, Dau-Ming, Liu, Mei-Ying, Liu, Hsin-Yun, Chen, Hsiao-Jan, Kao, Shu-Min, Wang, Li-Yun, Ho, Huey-Jane, Chuang, Chih-Kuang, and Lin, Shuan-Pei
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NEWBORN screening ,LYSOSOMES ,HEMATOPOIETIC stem cell transplantation ,TANDEM mass spectrometry ,MUCOPOLYSACCHARIDOSIS ,ENZYME replacement therapy - Abstract
Background: Mucopolysaccharidosis II (MPS II) is an X-linked disorder resulting from a deficiency in lysosomal enzyme iduronate-2-sulfatase (IDS), which causes the accumulation of glycosaminoglycans (GAGs) in the lysosomes of many tissues and organs, leading to progressive cellular dysfunction. An MPS II newborn screening program has been available in Taiwan since 2015. The aim of the current study was to collect and analyze the long-term follow-up data of the screen-positive subjects in this program. Methods: From August 2015 to April 2022, 548,624 newborns were screened for MPS II by dried blood spots using tandem mass spectrometry, of which 202 suspected infants were referred to our hospital for confirmation. The diagnosis of MPS II was confirmed by IDS enzyme activity assay in leukocytes, quantitative determination of urinary GAGs by mass spectrometry, and identification of the IDS gene variant. Results: Among the 202 referred infants, 10 (5%) with seven IDS gene variants were diagnosed with confirmed MPS II (Group 1), 151 (75%) with nine IDS gene variants were classified as having suspected MPS II or pseudodeficiency (Group 2), and 41 (20%) with five IDS gene variants were classified as not having MPS II (Group 3). Long-term follow-up every 6 months was arranged for the infants in Group 1 and Group 2. Intravenous enzyme replacement therapy (ERT) was started in four patients at 1, 0.5, 0.4, and 0.5 years of age, respectively. Three patients also received hematopoietic stem cell transplantation (HSCT) at 1.5, 0.9, and 0.6 years of age, respectively. After ERT and/or HSCT, IDS enzyme activity and the quantity of urinary GAGs significantly improved in all of these patients compared with the baseline data. Conclusions: Because of the progressive nature of MPS II, early diagnosis via a newborn screening program and timely initiation of ERT and/or HSCT before the occurrence of irreversible organ damage may lead to better clinical outcomes. The findings of the current study could serve as baseline data for the analysis of the long-term effects of ERT and HSCT in these patients. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
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6. Pursuing quality and equity of higher education: A review of policies and practices in east Asia.
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Peng, Samuel S. and Wang, Li-Yun
- Subjects
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EDUCATIONAL accountability , *HIGHER education research , *UNIVERSITY & college admission , *RIGHT to education , *EDUCATION & economics research , *HIGHER education - Abstract
Although expansion of higher education in East Asia has had a positive impact on Asian societies, it has created a number of challenges relating to accountability. [ABSTRACT FROM AUTHOR]
- Published
- 2008
7. Nationwide Newborn Screening Program for Mucopolysaccharidoses in Taiwan and an Update of the "Gold Standard" Criteria Required to Make a Confirmatory Diagnosis.
- Author
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Chuang, Chih-Kuang, Lee, Chung-Lin, Tu, Ru-Yi, Lo, Yun-Ting, Sisca, Fran, Chang, Ya-Hui, Liu, Mei-Ying, Liu, Hsin-Yun, Chen, Hsiao-Jan, Kao, Shu-Min, Wang, Li-Yun, Ho, Huey-Jane, Lin, Hsiang-Yu, and Lin, Shuan-Pei
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NEWBORN screening ,LYSOSOMAL storage diseases ,NEWBORN infants ,DIAGNOSIS ,SYMPTOMS - Abstract
Mucopolysaccharidoses (MPSs) are a group of lysosomal storage diseases (LSDs) caused by an inherited gene defect. MPS patients can remain undetected unless the initial signs or symptoms have been identified. Newborn screening (NBS) programs for MPSs have been implemented in Taiwan since 2015, and more than 48.5% of confirmed cases of MPS have since been referred from these NBS programs. The purpose of this study was to report the current status of NBS for MPSs in Taiwan and update the gold standard criteria required to make a confirmative diagnosis of MPS, which requires the presence of the following three laboratory findings: (1) elevation of individual urinary glycosaminoglycan (GAG)-derived disaccharides detected by MS/MS-based assay; (2) deficient activity of a particular leukocyte enzyme by fluorometric assay; and (3) verification of heterogeneous or homogeneous variants by Sanger sequencing or next generation sequencing. Up to 30 April 2021, 599,962 newborn babies have been screened through the NBS programs for MPS type I, II, VI, and IVA, and a total of 255 infants have been referred to MacKay Memorial Hospital for a confirmatory diagnosis. Of these infants, four cases were confirmed to have MPS I, nine cases MPS II, and three cases MPS IVA, with prevalence rates of 0.67, 2.92, and 4.13 per 100,000 live births, respectively. Intensive long-term regular physical and laboratory examinations for asymptomatic infants with confirmed MPS or with highly suspected MPS can enhance the ability to administer ERT in a timely fashion. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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8. Status of newborn screening and follow up investigations for Mucopolysaccharidoses I and II in Taiwan.
- Author
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Chuang CK, Lin HY, Wang TJ, Huang YH, Chan MJ, Liao HC, Lo YT, Wang LY, Tu RY, Fang YY, Chen TL, Ho HC, Chiang CC, and Lin SP
- Subjects
- Female, Humans, Iduronidase metabolism, Infant, Newborn, Male, Sequence Analysis, DNA methods, Taiwan, Tandem Mass Spectrometry, Mucopolysaccharidosis I diagnosis, Mucopolysaccharidosis II diagnosis, Neonatal Screening methods
- Abstract
Background: Mucopolysaccharidoses (MPS) are lysosomal storage diseases in which mutations of genes encoding for lysosomal enzymes cause defects in the degradation of glycosaminoglycans (GAGs). The accumulation of GAGs in lysosomes results in cellular dysfunction and clinical abnormalities. The early initiation of enzyme replacement therapy (ERT) can slow or prevent the development of severe clinical manifestations. MPS I and II newborn screening has been available in Taiwan since August 2015. Infants who failed the recheck at recall were referred to MacKay Memorial Hospital for a detailed confirmatory diagnosis., Methods: From August 2015 to November 2017, 294,196 and 153,032 infants were screened using tandem mass spectrometry for MPS I and MPS II, respectively. Of these infants, 84 suspected cases (eight for MPS I; 76 for MPS II) were referred for confirmation. Urinary first-line biochemistry examinations were performed first, including urinary GAG quantification, two-dimensional electrophoresis, and tandem mass spectrometry assay for predominant disaccharides derived from GAGs. If the results were positive, a confirmative diagnosis was made according to the results of leukocyte enzymatic assay and molecular DNA analysis. Leukocyte pellets were isolated from EDTA blood and used for fluorescent α-iduronidase (IDUA) or iduronate-2-sulfatase (IDS) enzymatic assay. DNA sequencing analysis was also performed., Results: Normal IDS and IDUA enzyme activities were found in most of the referred cases except for four who were strongly suspected of having MPS I and three who were strongly suspected of having MPS II. Of these infants, three with novel mutations of the IDS gene (c.817C > T, c.1025A > G, and c.311A > T) and four with two missense mutations of the IDUA gene (C.300-3C > G, c.1874A > C; c.1037 T > G, c.1091C > T) showed significant deficiencies in IDS and IDUA enzyme activities (< 5% of mean normal activity), respectively. Urinary dermatan sulfate and heparan sulfate quantitative analyses by tandem mass spectrometry also demonstrated significant elevations. The prevalence rates of MPS I and MPS II in Taiwan were 1.35 and 1.96 per 100,000 live births, respectively., Conclusions: The early initiation of ERT for MPS can result in better clinical outcomes. An early confirmatory diagnosis increases the probability of receiving appropriate medical care such as ERT quickly enough to avoid irreversible manifestations. All high risk infants identified in this study so far remain asymptomatic and are presumed to be affected with the attenuated disease variants.
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- 2018
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9. Self-care behavior, hope, and social support in Taiwanese patients awaiting heart transplantation.
- Author
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Wang LY, Chang PC, Shih FJ, Sun CC, and Jeng C
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Taiwan, Adaptation, Psychological, Heart Transplantation, Self Care, Social Support, Waiting Lists
- Abstract
Objective: The purpose of this study was to examine the self-care behavior, hope, and social support in patients awaiting heart transplantation and to explore all the correlative and related factors., Methods: In total, 45 participants who met the selection criteria were selected by purposive sampling from four medical centers in Taiwan. The three instruments Self-Care Behavior Scale, Herth Hope Index (HHI), and Social Support Inventory were used for data collection., Results: Significant, positive correlations among self-care behavior, hope, and social support were observed. Social support was the best predictive factor for both self-care behavior and hope., Conclusion: The outcomes of this study can help medical care personnel better understand the self-care behavior, hope, and social support in patients awaiting heart transplantation and can also serve as a reference when developing relevant interventions for these patients.
- Published
- 2006
- Full Text
- View/download PDF
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