1. Catheter-Directed Thrombolysis for Acute Limb Ischemia in an Asian Population.
- Author
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Ebben HP, Yang HT, Hoksbergen AWJ, Wisselink W, Ko PJ, and Yeung KK
- Subjects
- Acute Disease, Adult, Aged, Aged, 80 and over, Amputation, Surgical, Asian People, Electronic Health Records, Female, Fibrinolytic Agents adverse effects, Hemorrhage chemically induced, Hemorrhage ethnology, Hospital Mortality, Humans, Ischemia diagnostic imaging, Ischemia ethnology, Ischemia physiopathology, Male, Middle Aged, Peripheral Arterial Disease diagnostic imaging, Peripheral Arterial Disease ethnology, Peripheral Arterial Disease physiopathology, Retrospective Studies, Risk Factors, Taiwan epidemiology, Thrombolytic Therapy adverse effects, Time Factors, Treatment Outcome, Vascular Patency, Catheterization, Peripheral adverse effects, Fibrinolytic Agents administration & dosage, Ischemia drug therapy, Peripheral Arterial Disease drug therapy, Thrombolytic Therapy methods
- Abstract
Background: The incidence of peripheral arterial occlusions in Asian populations is likely to increase exponentially in the present and future decades due to the adapted Western lifestyle in metropolitan Asian life, extended life expectancies, and high rates of smoking. The literature on thrombolytic treatment of peripheral arterial occlusions in Asian populations is limited. Therefore, we evaluated the thrombolysis results in a real-world contemporary Asian cohort of patients with peripheral arterial occlusions., Methods: Retrospective review of all electronic patient records of patients who underwent thrombolytic therapy for peripheral arterial occlusions between July 2011 and July 2016 was conducted. Outcomes were angiographic patency, clinical success, bleeding complications, amputation rates, and mortality rates., Results: In total, 82 patients (median age 66 years, range 34-95) underwent catheter-directed thrombolysis. Median treatment duration was 26 hr (3-209). Angiographic patency and clinical success rates were 64% and 66%, respectively. Bleeding complications occurred in 12% of patients of which 6% were major. Amputation-free rates were 81%, 67%, and 63% for 30 days, 6 months, and 1 year, respectively. In-hospital mortality was 6%., Conclusions: This study demonstrates that thrombolytic treatment of peripheral arterial occlusions in an Asian patient cohort yields comparable treatment success rates to Western cohorts; however, higher rates of bleeding complications are hazardous and remain a detrimental drawback of this treatment., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2019
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