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This study tested cross cultural measurement equivalence of three identity constructs by testing the factor invariance among participants from four nations. Data from measures of identity exploration, commitment, and distress were collected from university students in Mainland China (n = 85), Taiwan (n = 117), Japan (n = 117), and the United States (n = 223) using the Ego Identity Process Questionnaire (EIPQ) and the Identity Distress Scale (IDS). Invariance was not found for the Exploration subscale of the EIPQ, and only partial invariance was found for the Commitment subscale. The Identity Distress Scale did demonstrate invariance across all four samples. Differences varied by degree of Westernization (globalization) of the cultures under study. The results question the cross cultural validity of the EIPQ, particularly the identity exploration subscale. Results are discussed in terms of avenues for improving the cross cultural validity of assessments of identity constructs and implications for interventions that target identity processes to promote positive youth development.

The reliability of weather radar data in real-time flood forecasting and early warning system remain ambivalent due to high uncertainty in Quantitative Precipitation Forecasts (QPF). In this study, a methodology is presented with the objective to improve the flood forecasting results with the application of radar rainfall calculated in three different ways. The QPF radar rainfall forecast data of four typhoon events in Fèngshān River Basin, Taiwan, were simulated using the WASH123D numerical model. The simulated results were corrected using a physical real-time correction technique and compared with direct simulation without correction for all three QPF calculation methods. According to model performance evaluation criteria, in the third method of QPF calculation, flood peak error was the lowest in all three methods, indicating better results for flood forecasting and can be used for flood early warning systems. The impact of the real-time correction technique was assessed using mass balance analysis. It was found that flow change is between 16% and 42% from direct simulation, indicating being on the safe side in case of a flood warning. However, the impact of the real-time physical correction on the water level itself is in a reasonable range. Still, QPF rainfall correction/calculation is more important to obtain accurate results for flood forecasting. Therefore, the application of real-time correction to correct the model water level has a certain degree of credibility, which is the mass balance of the model. This approach is recommended for flood forecasting early warning systems. [ABSTRACT FROM AUTHOR]

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Background: A family history of liver cancer increases the risk of developing hepatocellular carcinoma (HCC) by 2-fold to 10-fold among patients with chronic hepatitis B virus (HBV). Previous genome-wide association studies have identified many possible susceptible loci associated with sporadic HBV-related HCC. However, despite family history being a well-known risk factor for HBV-related HCC, to the authors' knowledge its genetic mechanisms and associating loci remain largely unknown or unexplored, most likely due to the relative rarity of familial HCC and the difficulty of sample collection.Methods: The authors conducted a genome-wide association study with 139 male cases with familial HBV-related HCC and 139 non-HCC male controls with chronic HBV. The results were corroborated further with an independent cohort of 101 patients with familial HBV-related HCC and comparison with both the 1000 Genomes Project and the Taiwan Biobank.Results: A total of 51 risk single-nucleotide polymorphisms (P≤1E-04) were identified in the association analyses, which included 2 clusters of associated single-nucleotide polymorphisms and haplotypes at 1q25.3 (glutamate-ammonia ligase [GLUL]/transmembrane epididymal protein 1 [TEDDM1]/long intergenic non-protein-coding RNA 272 [LINC00272]/regulator of G-protein signaling-like 1 [RGSL1]) and 17q11.2 (solute carrier family 13 member 2 [SLC13A2]/forkhead box N1 [FOXN1]). Both the GLUL and SLC13A2/FOXN1 haplotypes have large effect sizes and were found to be different from those found from genome-wide association studies of sporadic HCCs.Conclusions: To the authors' knowledge, the current study is the first genome-wide association study to identify genetic factors for familial HBV-related HCC. The results identified 2 large effect susceptible haplotypes located at GLUL and SLC13A2/FOXN1. The current study findings also suggest different genetic susceptibility between familial and sporadic HBV-related HCC. Cancer 2017;123:3966-76. © 2017 American Cancer Society. [ABSTRACT FROM AUTHOR]

Abstract: Cancer is the leading cause of death in the world, and therefore, identifying advanced anticancer drugs is the most important objective of cancer research. However, at present, most synthetic anticancer drugs developed cause serious side effects thereby reducing their therapeutic efficiency. In a previous study, we have reported that culture filtrates from Barnettozyma spp. can not only maintain their lethal effect under physical environment, but can also exert stronger cytotoxicity to the hepatoma cell line HepG2 than to the normal Chang's liver cell. Herein, we further classify the types of liver cancer cell death, and identify those proteins responsible for the cell death by matrix-assisted laser desorption/ionization–time-of-flight spectra to study the possible mechanism of lethal culture filtrate from a special Taiwan killer yeast Barnettozyma spp. (EN14S14). Results of our preliminary study indicated that autophagic induction is most likely the major form of HepG2 cell death, which is induced by the “killing” culture filtrate. Proteins differentially expressed after treatment fell into three major categories, namely, metabolism, cytoskeleton, and signal transduction. [Copyright &y& Elsevier]

Purpose – This research examines the relationships among transformational/transactional leadership styles (TFLs/TSLs), organizational justice, trust, organizational commitment, and organizational citizenship behaviors (OCBs) in the context of international tourist hotels in Taipei. The purpose of this paper is to establish a comprehensive model of TFLs/TSLs in human resource management and to figure out which is the better leadership style in regards to the hospitality industry. Design/methodology/approach – A total of 700 questionnaires were distributed to the staff of eight international hotels, yielding 358 valid responses. Findings – TFLs/TSLs affect procedural and distributive justice significantly and positively. Managers using TFLs can induce trust of employees. TFLs positively affect organizational commitment through distributive justice and trust, while TSLs induce organizational commitment through distributive justice. Distributive justice has directly positive impact on trust. Distributive justice-organizational commitment is a positive link. Interestingly, TSLs influence organizational commitment negatively and significantly. As expected, trust can lead to organizational commitment and both trust and organizational commitment have positive impact on OCBs. Originality/value – The results could be used as the basis for improving human resources management in such a collectivistic culture as Chinese society. [ABSTRACT FROM AUTHOR]

This study tested cross cultural measurement equivalence of three identity constructs by testing the factor invariance among participants from four nations. Data from measures of identity exploration, commitment, and distress were collected from university students in Mainland China ( n = 85), Taiwan ( n = 117), Japan ( n = 117), and the United States ( n = 223) using the Ego Identity Process Questionnaire (EIPQ) and the Identity Distress Scale (IDS). Invariance was not found for the Exploration subscale of the EIPQ, and only partial invariance was found for the Commitment subscale. The Identity Distress Scale did demonstrate invariance across all four samples. Differences varied by degree of Westernization (globalization) of the cultures under study. The results question the cross cultural validity of the EIPQ, particularly the identity exploration subscale. Results are discussed in terms of avenues for improving the cross cultural validity of assessments of identity constructs and implications for interventions that target identity processes to promote positive youth development. [ABSTRACT FROM AUTHOR]

Objective: The molecular pathogenesis of malignant gliomas, characterized by diverse tumor histology with differential prognosis, remains largely unelucidated. An APOBEC3 deletion polymorphism, with a deletion in APOBEC3B, has been correlated to risk and prognosis in several cancers, but its role in glioma is unclear. The authors aimed to examine the clinical relevance of the APOBEC3 deletion polymorphism to glioma risk and survival in a glioma patient cohort in Taiwan., Methods: The authors detected deletion genotypes in 403 glioma patients and 1365 healthy individuals in Taiwan and correlated the genotypes with glioma risk, clinicopathological factors, patient survival, and patient sex. APOBEC3 gene family expression was measured and correlated to the germline deletion. A nomogram model was constructed to predict patient survival in glioma., Results: The proportion of APOBEC3B-/- and APOBEC3B+/- genotypes was higher in glioblastoma (GBM) patients than healthy individuals and correlated with higher GBM risk in males. A higher percentage of cases with APOBEC3B- was observed in male than female glioma patients. The presence of APOBEC3B-/- was correlated with better overall survival (OS) in male astrocytic glioma patients. No significant correlation of the genotypes to glioma risk and survival was observed in the female patient cohort. Lower APOBEC3B expression was observed in astrocytic glioma patients with APOBEC3B-/- and was positively correlated with better OS. A 5-factor nomogram model was constructed based on male patients with astrocytic gliomas in the study cohort and worked efficiently for predicting patient OS., Conclusions: The germline APOBEC3 deletion was associated with increased GBM risk and better OS in astrocytic glioma patients in the Taiwan male population. The APOBEC3B deletion homozygote was a potential independent prognostic factor predicting better survival in male astrocytic glioma patients.

About 4% of the population in Taiwan are seropositive for anti-HCV Ab and 70% with HCV RNA. To address this high chronic hepatitis C disease load, Taiwan National Health Insurance started reimbursing genotype-specific DAAs in 2017 and pangenotype DAAs in mid-2018. With a 97% SVR12 rate, there were still 2-3% of patients that failed to clear HCV. To understand the causes of DAA failure in Taiwan, we conducted a multi-center, clinical, and virologic study. A total of 147 DAA-failure patients were recruited, and we searched HCV NS3/4A, NS5A and NS5B for known resistance-associated substitutions (RASs) by population sequencing, and conducted whole genome sequencing (WGS) for those without known RASs. A total of 107 patients received genotype-specific DAAs while 40 had pangenotype DAAs. Clinically, the important cause of failure is poor adherence. Virologically, common RASs in genotype-specific DAAs were NS5A-L31, NS5A-Y93, and NS5B-C316, while common RASs in pangenotype DAAs were NS5A-L31, NS5A-A/Q/R30, and NS5A-Y93. Additionally, new amino acid changes were found by WGS. Finally, we identified 12 cases with inconsistent baseline and post-treatment HCV genotypes, which is suggestive of re-infection rather than treatment failure. Our study described the drug resistance profile for DAA failure in Taiwan, showing differences from other countries.

A new sciaenid fish, Johnius taiwanensis, is described from the southeast coast of mainland China from Zhejiang to Guangdong, Hong Kong, and west coast of Taiwan. Johnius taiwanensis sp. nov. can be distinguished from other Johnius species by having a grayish dorsal half of body divided by a clear line from a whitish ventral half, and a black spot at the dorsal half of pectoral-fin axil, appearing as a distinct dot at the most dorsal point of the pectoral-fin base. First dorsal fin black tipped, other fins pale to dusky but never darkly pigmented. The species lacks distinctly enlarged teeth on upper and lower jaws. Body scales ctenoid, moderately large, with five or six rows between first dorsal-fin origin and lateral line. It is one of the most abundant sciaenids found in the shallow coastal waters (20 m) of southeast mainland China and the west coast of Taiwan. It has often been misidentified as J. macrorhynus in the region. Phylogenetic analysis from all 27 sciaenid species found in Chinese waters based on the complete COI and 16S rRNA gene sequences confirmed that the genus Johnius is monophyletic and J. taiwanensis is placed as a sister species of J. trewavasae. Acoustic analysis has shown that J. taiwanensis produces a unique sound among fishes in Taiwan coastal waters.

Background: Understanding the relapse risk among different illicit drugs is vital for developing an adequate relapse prevention policy. Therefore, the current study aims to explore the potential difference in long-term relapse rates between youths who use ketamine and those who use stimulants (3,4-Methylenedioxymethamphetamine [MDMA] or methamphetamine)., Methods: The study's participants included 92 youths with ketamine use (ketamine group, mean age: 16.0 years) and 43 youths with MDMA/methamphetamine use (stimulants group, mean age: 16.1 years) that had undergone a family-oriented treatment program in a medical center in Taiwan. All participants were followed up for a maximum of 7 years in order to observe their long-term outcomes with regard to substance use relapse., Results: During the follow-up period, compared to the 34.8% relapse rate in ketamine users, their counterparts who used MDMA or methamphetamine had a significantly higher relapse rate (60.5%, Adjusted HR = 1.86, 95%CI: 1.06-3.28, p = 0.032). Of the youths in the ketamine group that relapsed, 65.6% continued to use ketamine in their relapse event, while 34.4% switched to MDMA or methamphetamine. Among the relapsing youths in the stimulants group, 84.6% continued to use MDMA or methamphetamine in their relapse event, while 15.4% switched to ketamine (p = 0.042)., Conclusions: Compared to adolescents who use ketamine, those using MDMA or methamphetamine had higher relapse rates and were more likely to use the same type of drug upon relapsing. These results can serve as a crucial reference for developing relapse prevention policies of illicit drugs for the youth population.