1. Case-Control Study of Clostridium innocuum Infection, Taiwan.
- Author
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Yi-Ching Chen, Yi-Chun Kuo, Mi-Chi Chen, Young-Da Zhang, Chyi-Liang Chen, Puo-Hsien Le, Cheng-Hsun Chiu, Chen, Yi-Ching, Kuo, Yi-Chun, Chen, Mi-Chi, Zhang, Young-Da, Chen, Chyi-Liang, Le, Puo-Hsien, and Chiu, Cheng-Hsun
- Subjects
CLOSTRIDIOIDES difficile ,VANCOMYCIN resistance ,CASE-control method ,CLOSTRIDIUM diseases ,CHRONIC kidney failure ,INTENSIVE care units ,ENTEROCOCCAL infections ,ANTIBIOTICS ,RESEARCH ,EVALUATION research ,COMPARATIVE studies - Abstract
Vancomycin-resistant Clostridium innocuum was recently identified as an etiologic agent for antibiotic-associated diarrhea in humans. We conducted a case-control study involving 152 C. innocuum-infected patients during 2014-2019 in Taiwan, using 304 cases of Clostridioides difficile infection (CDI) matched by diagnosis year, age (+2 years), and sex as controls. The baseline characteristics were similar between the 2 groups. C. innocuum-infected patients experienced more extraintestinal clostridial infection and gastrointestinal tract-related complications than did patients with CDI. The 30-day mortality rate among C. innocuum-infected patients was 14.5%, and the overall rate was 23.0%. Chronic kidney disease, solid tumor, intensive care unit admission, and shock status were 4 independent risk factors for death. C. innocuum identified from clinical specimens should be recognized as a pathogen requiring treatment, and because of its intrinsic vancomycin resistance, precise identification is necessary to guide appropriate and timely antimicrobial therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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