1. LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations.
- Author
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Wu YR, Tan LC, Fu X, Chen CM, Au WL, Chen L, Chen YC, Prakash KM, Zheng Y, Lee-Chen GJ, Zhao Y, Zeng JS, Tan EK, and Pei Z
- Subjects
- Aged, Case-Control Studies, China, Cohort Studies, Female, Genotyping Techniques, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Male, Middle Aged, Risk Factors, Singapore, Taiwan, Asian People, Parkinson Disease ethnology, Parkinson Disease genetics, Polymorphism, Single Nucleotide, Protein Serine-Threonine Kinases genetics
- Abstract
It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population.
- Published
- 2012
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