1. Antifungal flavonoids from Hildegardia barteri.
- Author
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Meragelman TL, Tucker KD, McCloud TG, Cardellina JH 2nd, and Shoemaker RH
- Subjects
- Antifungal Agents chemistry, Antifungal Agents pharmacology, Chromones chemistry, Chromones isolation & purification, Flavonoids chemistry, Flavonoids pharmacology, Isoflavones chemistry, Isoflavones pharmacology, Microbial Sensitivity Tests, Molecular Structure, Tanzania, Antifungal Agents isolation & purification, Candida drug effects, Flavonoids isolation & purification, Isoflavones isolation & purification, Malvaceae chemistry, Plants, Medicinal chemistry
- Abstract
A new isoflavan, (3R)-6,2'-dihydroxy-7-methoxy-4',5'-methylenedioxyisoflavan, hildegardiol (1), and two known flavonoids, 2-hydroxymaackiain (2) and farrerol (3), were isolated from the antifungal root extract of Hildegardia barteri. The pterocarpan 2 was largely responsible for the observed antifungal activity.
- Published
- 2005
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