13 results on '"misoprostol"'
Search Results
2. Provision of harm-reduction services to limit unsafe abortion in Tanzania.
- Author
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Kahabuka, Catherine, Pembe, Andrea, and Meglioli, Alejandra
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ABORTION complications , *FOLLOW-up studies (Medicine) , *MORTALITY , *PUBLIC health , *CONTRACEPTION - Abstract
Objective: To investigate the feasibility of providing harm-reduction services to reduce unsafe abortion in Tanzania.Methods: A cross-sectional study was conducted among 110 women who received harm-reduction counseling at a public health center in Dar es Salaam between February 10 and October 10, 2014. Background and clinical information was collected for all women; a subgroup (n=50) undertook a semi-structured survey that measured the type of services women received, women's perception of the services, and pregnancy outcome. The main study outcomes were attendance at the follow-up visit, type and quality of information women received on both visits, and misoprostol use for pregnancy termination.Results: Overall, 55 (50.0%) women attended follow-up services. Misoprostol was used for induced abortion among 54 (98.2%); 38 (70.4%) of these women had obtained contraception at the follow-up visit. Likelihood of attendance for follow-up was increased among women who were older than 34 years (odds ratio [OR] 2.2, 95% confidence interval [CI] 0.1-35.8), were married (OR 2.1, 95% CI 0.8-5.7), and had a post-primary education level (OR 2.0, 95% CI 0.8-5.3). On average, 44 (87.0%) women received all required information at the initial counseling session and none reported major complications that required hospitalization.Conclusion: Harm-reduction services for unsafe abortion are feasible and acceptable, and could provide an excellent opportunity to fight abortion-related morbidity and mortality in Tanzania. [ABSTRACT FROM AUTHOR]- Published
- 2017
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3. Women's Health in Women's Hands: A Pilot Study Assessing the Feasibility of Providing Women With Medications to Reduce Postpartum Hemorrhage and Sepsis in Rural Tanzania.
- Author
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Webber, Gail C. and Chirangi, Bwire
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HEMORRHAGE prevention , *PUERPERAL disorders , *SEPTICEMIA prevention , *INTERVIEWING , *RESEARCH methodology , *MOTHERS , *MATERNAL mortality , *RESEARCH funding , *RURAL conditions , *SURVEYS , *WOMEN'S health , *PILOT projects , *MISOPROSTOL , *DATA analysis software , *DESCRIPTIVE statistics , *PREVENTION - Abstract
In rural Africa, deaths from childbirth are common and access to health care facilities with skilled providers is very limited. Leading causes of death for women are bleeding and infection. In this pilot study, we establish the feasibility of distributing oral medications to women in rural Tanzania to self-administer after delivery to reduce bleeding and infection. Of the 642 women provided with medications, 90% of the women took them appropriately, while the remaining 10% did not require them. We conclude that is it feasible to distribute oral medications to rural women to self-administer after delivery. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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4. A randomized controlled trial on the value of misoprostol for the treatment of retained placenta in a low-resource setting.
- Author
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van Beekhuizen, Heleen J., Tarimo, Vincent, Pembe, Andrea B., Fauteck, Heiner, and Lotgering, Fred K.
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RANDOMIZED controlled trials , *PLACENTA diseases , *HEALTH facilities , *DRUG efficacy , *MISOPROSTOL , *MEDICATION safety , *PLACEBOS , *THERAPEUTICS - Abstract
Abstract: Objective: To evaluate the efficacy and safety of misoprostol among patients with retained placenta in a low-resource setting. Methods: A prospective, multicenter, randomized, double-blind, placebo-controlled trial was carried out in Tanzania between April 2008 and November 2011. It included patients who delivered at a gestational age of 28weeks or more and had blood loss of 750mL or less at 30minutes after delivery. Sublingual misoprostol (800μg) was compared with placebo as the primary treatment. Power analysis showed that 117 patients would be required to observe a reduction of 40% in the incidence of manual removal of the placenta (MRP; P =0.05, 80% power), the primary outcome. The secondary outcomes were blood loss and number of blood transfusions. Results: Interim analysis after recruitment of 95 patients showed that incidence of MRP, total blood loss, and incidence of blood transfusions were similar in the misoprostol (MRP, 40%; blood loss, 803mL; blood transfusion, 15%) and placebo (MRP, 33%, blood loss 787mL, blood transfusion, 23%) groups. The trial was stopped because continuation would not alter the interim conclusion that misoprostol was ineffective. Conclusion: Treatment with misoprostol was found to have no clinically significant beneficial effect among women with retained placenta. Clinical Trial Registration: Current Controlled Trials ISRCTN16104753 [Copyright &y& Elsevier]
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- 2013
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5. Community-Based Availability of Misoprostol: Is It Safe?
- Author
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Prata, Ndola, Mbaruku, Godfrey, Grossman, Amy A., Holston, Martine, and Hsieh, Kristina
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MISOPROSTOL ,DRUG side effects ,PUERPERAL disorders ,CHILDBIRTH at home - Abstract
Copyright of African Journal of Reproductive Health is the property of Women's Health & Action Research Centre and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2009
6. Misoprostol for treatment of incomplete abortion at the regional hospital level: results from Tanzania.
- Author
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Shwekerela, B., Kalumuna, R., Kipingili, R., Mashaka, N., Westheimer, E., Clark, W., and Winikoff, B.
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ABORTION , *BIRTH control , *UTERINE fibroids , *MEDICAL care , *PREGNANT women - Abstract
Objective To investigate the safety, efficacy, and acceptability of misoprostol versus manual vacuum aspiration (MVA) for treatment of incomplete abortion. Design A prospective open-label randomised trial. Setting Kagera Regional Hospital, Bukoba, Tanzania. Sample Three hundred women with a clinical diagnosis of incomplete abortion and a uterine size <12 weeks. Methods A total of 150 women were randomised to either a single dose of 600 micrograms of oral misoprostol or MVA. If abortion was clinically complete at 7-day follow up, the woman was released from the study. If it was still incomplete, the woman was offered the choice of an additional 1-week follow up or immediate MVA. Cases still incomplete after a further week were offered MVA. Main outcome measures Incidence of successful abortion (success defined as no secondary surgical intervention provided), incidence of adverse effects, patient satisfaction. Results Success was very high in both arms (misoprostol: 99%; MVA: 100%; difference not significant). Most adverse effects were higher in the misoprostol arm, although the mean pain score was higher in the MVA arm (3.0 versus 3.5; P < 0.001). More women were very satisfied with misoprostol (75%) than with MVA (55%, P= 0.001), and a higher proportion of women in the misoprostol arm said that they would recommend the treatment to a friend (95% versus 75%, P < 0.001). Conclusion Misoprostol is as effective as MVA at treating incomplete abortion at uterine size of <12 weeks. The acceptability of misoprostol appears higher. Given the many practical advantages of misoprostol over MVA in low-resource settings, misoprostol should be more widely available for treatment of incomplete abortion in the developing world. [ABSTRACT FROM AUTHOR]
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- 2007
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7. Controlling postpartum hemorrhage after home births in Tanzania
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Prata, N., Mbaruku, G., Campbell, M., Potts, M., and Vahidnia, F.
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HEMORRHAGE , *ARTERIAL injuries , *THERAPEUTICS , *HEMORRHAGE prevention , *PUERPERAL disorders , *CHILDBIRTH at home , *COMPARATIVE studies , *RESEARCH methodology , *MEDICAL cooperation , *MEDICAL referrals , *MEDICALLY underserved areas , *RECTAL medication , *RESEARCH , *STATISTICAL sampling , *EVALUATION research , *RANDOMIZED controlled trials , *TREATMENT effectiveness , *MISOPROSTOL , *OXYTOCICS , *PREVENTION - Abstract
Objectives: Determine safety of household management of postpartum hemorrhage (PPH) with 1000 microg of rectal misoprostol, and assess possible reduction in referrals and the need for additional interventions.Methods: Traditional birth attendants (TBAs) in Kigoma, Tanzania were trained to recognize PPH (500 ml of blood loss). Blood loss measurement was standardized by using a local garment, the "kanga". TBAs in the intervention area gave 1000 microg of misoprostol rectally when PPH occurred. Those in the non-intervention area referred the women to the nearest facility.Results: 454 women in the intervention and 395 in the non-intervention areas were eligible. 111 in the intervention area and 73 in the non-intervention had PPH. Fewer than 2% of the PPH women in the intervention area were referred, compared with 19% in the non-intervention.Conclusion: Misoprostol is a low cost, easy to use technology that can control PPH even without a medically trained attendant. [ABSTRACT FROM AUTHOR]- Published
- 2005
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8. Improving health care facility birth rates in Rorya District, Tanzania: a multiple baseline trial.
- Author
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Webber G, Chirangi B, Magatti N, Mallick R, and Taljaard M
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- Adolescent, Adult, Child, Community Health Workers education, Female, Humans, Infant, Middle Aged, Postnatal Care trends, Pregnancy, Prenatal Care trends, Research Design, Rural Population, Social Determinants of Health, Tanzania epidemiology, Young Adult, Birth Rate, Delivery, Obstetric, Health Education methods, Health Facilities, Health Services Accessibility
- Abstract
Background: Rates of maternal mortality and morbidity in Africa remain unacceptably high, as many women deliver at home, without access to skilled birth attendants and life-saving medications. In rural Tanzania, women face significant barriers accessing health care facilities for their deliveries., Methods: From January 2017 to February 2019 we conducted a multiple baseline (interrupted time series) trial within the four divisions of Rorya District, Tanzania. We collected baseline data, then sequentially introduced a complex intervention in each of the divisions, in randomized order, over 3 month intervals. We allowed for a 6 month transition period to avoid contamination between the pre- and post-intervention periods. The intervention included using community health workers to educate about safe delivery, distribution of birth kits with misoprostol, and a transport subsidy for women living a distance from the health care facility. The primary outcome was the health facility birth rate, while the secondary outcomes were the rates of antenatal and postpartum care and postpartum hemorrhage. Outcomes were analyzed using fixed effects segmented logistic regression, adjusting for age, marital status, education, and parity. Maternal and baby morbidity/mortality were analyzed descriptively., Results: We analyzed data from 9565 pregnant women (2634 before and 6913 after the intervention was implemented). Facility births increased from 1892 (71.8%) before to 5895 (85.1%) after implementation of the intervention. After accounting for the secular trend, the intervention was associated with an immediate increase in the odds of facility births (OR = 1.51, 95% CI 1.14 to 2.01, p = 0.0045) as well as a small gradual effect (OR = 1.03 per month, 95% CI 1.00 to 1.07, p = 0.0633). For the secondary outcomes, there were no statistically significant immediate changes associated with the intervention. Rates of maternal and baby morbidity/mortality were low and similar between the pre- and post-implementation periods., Conclusions: Access to health care facilities can be improved through implementation of education of the population by community health workers about the importance of a health care facility birth, provision of birth kits with misoprostol to women in late pregnancy, and access to a transport subsidy for delivery for women living at a distance from the health facility., Clinical Trials Registration: NCT03024905 19/01/2017., (© 2022. The Author(s).)
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- 2022
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9. Facilitating women’s access to misoprostol through community-based advocacy in Kenya and Tanzania.
- Author
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Coeytaux, Francine, Hessini, Leila, Ejano, Nondo, Obbuyi, Albert, Oguttu, Monica, Osur, Joachim, and Shuken, Kristen
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ABORTION policy , *MISOPROSTOL , *WOMEN patients , *GYNECOLOGIC drugs , *HEMORRHAGE , *THERAPEUTICS - Abstract
Abstract: Objective: To explore the feasibility of educating communities about gynecologic uses for misoprostol at the community level through community-based organizations in countries with restrictive abortion laws. Methods: In 2012, the Public Health Institute and Ipas conducted an operations research study, providing small grants to 28 community-based organizations in Kenya and Tanzania to disseminate information on the correct use of misoprostol for both abortion and postpartum hemorrhage. These groups were connected to pharmacies selling misoprostol. The primary outcomes of the intervention were reports from the community-based organizations regarding the health education strategies that they had developed and implemented to educate their communities. Results: The groups developed numerous creative strategies to reach diverse audiences and ensure access to misoprostol pills. Given the restrictive environment, the groups attributed their success to having addressed the use of misoprostol for both indications (abortion and postpartum hemorrhage) and to using a harm reduction approach to frame the advocacy. Conclusion: This initiative proves that, even where abortion is legally restricted and socially stigmatized, community-based organizations can publicly and openly share information about misoprostol and refer it to women by using innovative and effective strategies, without political backlash. Furthermore, it shows that communities are eager for this information. [Copyright &y& Elsevier]
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- 2014
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10. Beyond the law: Misoprostol and medical abortion in Dar es Salaam, Tanzania.
- Author
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Solheim, I.H., Moland, K.M., Kahabuka, C., Pembe, A.B., and Blystad, A.
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ABORTION laws , *ABORTION , *DRUGS , *FOCUS groups , *SEXUAL health , *INTERVIEWING , *PATIENT safety , *RELIGION , *RESEARCH , *RESEARCH funding , *WORLD health , *REPRODUCTIVE health , *QUALITATIVE research , *CULTURAL values , *MISOPROSTOL - Abstract
Misoprostol has during the past few years become an important obstetric drug used for different purposes both within and outside hospitals in Tanzania. In this paper, we analyze how misoprostol is perceived, accessed and used off-label as an abortion drug in the city and region of Dar es Salaam. The study took place in Dar es Salaam's three districts from July to November 2015, and had a qualitative explorative approach. We carried out in-depth interviews (42) with the following main categories of informants: women having undergone medical abortion (15), health care workers with experiences from post abortion care (16) and drug vendors (11). Focus group discussions (10) were carried out with young women. A client simulation study was carried out in 64 drugstores across Dar es Salaam assessing the availability of misoprostol and the advice given concerning its use. In addition, shorter qualitative interviews were carried out with representatives of NGOs and public agencies working with sexual and reproductive health issues (17). Our findings reveal that in Dar es Salaam, misoprostol is well known, available and accessed for abortion purposes through drugstores and health providers. Women tend to prefer misoprostol over other abortion methods since it allows for a private, low-cost, safer and less uncomfortable abortion experience. But, while misoprostol facilitates women's agency in the process of seeking abortion, a series of obstacles shaped by a restrictive abortion law and an unregulated pharmaceutical market hinder its safe use. Central obstacles are profit-seeking providers, suboptimal user instructions and poor provider follow-up. In the discussion of the material we draw upon Van der Geest, Hardon and Whyte's concept of the 'social life of pharmaceuticals' and indicate the ways in which misoprostol acts as an agent of change in the social relations connected to abortion. • Misoprostol is commonly used off-label for medical abortion in Dar es Salaam. • Misoprostol changes who controls access to abortion in restrictive settings. • Access to medical abortion enhances women's abortion related agency. • Access to safe medical abortion is context dependent. • Misoprostol and medical abortion may be studied as a social and cultural phenomenon. [ABSTRACT FROM AUTHOR]
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- 2020
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11. Experiences of a multiple intervention trial to increase maternity care access in rural Tanzania: Focus group findings with women, nurses and community health workers.
- Author
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Webber G, Chirangi B, and Magatti N
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- Female, Focus Groups, Humans, Maternal Health Services, Pregnancy, Qualitative Research, Rural Population, Tanzania, Community Health Workers, Health Services Accessibility, Nurses, Prenatal Care
- Abstract
Objectives: In order to improve maternal health and women's access to maternity care services in Rorya District, Mara, Northern Tanzania, we introduced several interventions across the district from 2018 to 2019. The interventions were workshops with nurses to encourage respectful care of women and transportation subsidies for women to reach the health facilities for delivery. In addition, we trained community health workers to educate couples about safe birthing options using m-health applications, to collaborate with nurses to distribute clean birth kits with misoprostol and to hold village meetings to shift community norms. This article reports on the experiences of women, community health workers and nurses during the study., Methods: Focus group discussions were conducted with a convenience sample of these groups to understand the successes and challenges of the interventions., Results: The workshops with nurses to encourage respectful maternity care and the birth kits with misoprostol were appreciated by all and were an incentive for women to seek health services. While the m-health applications were innovative, the system required significant oversight and a stable network. The village meetings demonstrated some success and should be expanded. Travel subsidies were problematic to implement and only helpful to the minority who received them., Conclusion: Multiple intervention strategies are needed to help women access maternity care services in rural locations and should be designed to meet needs within the local context. In Rorya District, access to quality health care was improved through training nurses to provide respectful care and using community health workers to educate the population about safe birthing practices and to provide women with clean birth kits. Despite the current limitations of m-health, there is much potential for development. Finding solutions to women's need for transport is a particular challenge and will likely require innovative community-based approaches.
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- 2020
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12. Induction of labor with misoprostol or oxytocin in Tanzania
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Kidanto, H.L., Kaguta, M.M., and van Roosmalen, J.
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OXYTOCIN , *MISOPROSTOL , *OXYTOCICS , *COMPARATIVE studies , *INDUCED labor (Obstetrics) , *RESEARCH methodology , *EVALUATION of medical care , *MEDICAL cooperation , *PREGNANCY , *RESEARCH , *EVALUATION research , *RANDOMIZED controlled trials , *THERAPEUTICS - Published
- 2007
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13. Using the kanga to measure postpartum blood loss
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Prata, N., Mbaruku, G., and Campbell, M.
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HEMORRHAGE diagnosis , *HEMORRHAGE treatment , *MISOPROSTOL , *OXYTOCICS , *PUERPERAL disorders , *CLOTHING & dress , *MEDICAL referrals , *SURGICAL dressings , *WEIGHTS & measures , *SEVERITY of illness index , *DIAGNOSIS , *THERAPEUTICS - Published
- 2005
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