Search

Creutzfeldt-Jakob disease is a rare and incurable form of rapidly progressive neurodegenerative disease. The disease is fatal, and most patients die within 1 year of diagnosis. Clinical features include progressive cognitive dysfunction, delusions or hallucinations, cerebellar ataxia, myoclonus, visual disturbances, extrapyramidal signs and eventually akinetic mutism. Most patients present with varied clinical presentation, hence making it difficult to diagnose at an early stage. We report five cases of sporadic Creutzfeldt-Jakob disease presenting to a Tasmanian hospital in Australia over a period of 52 months. We highlight significant clinical features in all our patients including few atypical presentations, emphasise on relevant clinical biomarkers and illustrate characteristic abnormalities on electroencephalogram and neuroimaging. [ABSTRACT FROM AUTHOR]

• We present challenge the traditional view of the EAC system and offer a new interpretation. • The EAC is a meandering stream that feeds a field of eddies. • We show that the Tasman Front and EAC Extension are rarely seen as distinct features.distinct, identifiable. • We summarise publishedworks on the EAC's path, separation, and eddy field. The traditional view of the East Australian Current (EAC), as depicted in many schematics, is of a continuous boundary current that flows along the shelf off eastern Australia, between approximately 18°S and about 32.5°S, where it separates from the coast and continues either towards New Zealand, along the Tasman Front; or towards Tasmania, as the EAC Extension. Additionally, it is widely recognised that eddies are prevalent in the EAC region – particularly south of the EAC separation. We revisit this long-standing paradigm and suggest that the EAC is perhaps better viewed as a continuous, meandering stream, flowing adjacent to the coast that "feeds" a field of mesoscale eddies. Observations show that EAC eddies are prevalent over a broad region of the western Tasman Sea, as far north as 25°S, typically with maximum intensity between 30 and 35°S. At any instant in time the EAC jet is usually evident as a poleward stream adjacent to the continental shelf edge. Other commonly accepted components of the EAC System, including the Tasman Front and EAC Extension, are rarely seen as distinct, identifiable features. Rather, these features are evident only in time-mean fields, when the eddy-variability is filtered out. It is also common for the EAC to be spatially discontinuous – due to the presence of eddies – often with multiple short streams that sometimes separate and re-attach to the coast. Recognition of the EAC as an eddy-dominated current system has seen many recent studies focus on various aspects of eddies in the EAC System, providing new insights into mesoscale ocean dynamics. Recent studies of individual eddies have shown that the circulation within eddies, including tilting and vertical motion, is more complex than previously understood. A summary of these studies, along with a review of the EAC System, particularly its path, separation, and eddy field is presented here. [ABSTRACT FROM AUTHOR]