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Start Over Descriptor "Paraoxon" Region tehran (iran)
2 results on '"Paraoxon"'

1. Findings from Baqiyatallah University of Medical Sciences Has Provided New Data on Antioxidants (Cumulative Effects of Paraoxon and Leptin On Oxidative Damages In Rat Tissues: Prophylactic and Therapeutic Roles of N-acetylcysteine).

Subjects
PARAOXON, LEPTIN, ACETYLCYSTEINE, RESPIRATORY agents, ANTIOXIDANTS
Abstract

Tehran, Iran, Acetylcysteine Therapy, Adipokines, Amino Acids, Antidotes, Antioxidants, Cysteine, Drugs and Therapies, Health and Medicine, Intercellular Signaling Peptides and Proteins, Leptin, Mucolytics, Organophosphorus Compounds, Acetylcysteine, Paraoxon, Pharmaceuticals, Protective Agents, Respiratory Agents, Respiratory Inhalant Products Keywords: Tehran; Iran; Acetylcysteine; Acetylcysteine Therapy; Adipokines; Amino Acids; Antidotes; Antioxidants; Cysteine; Drugs and Therapies; Health and Medicine; Intercellular Signaling Peptides and Proteins; Leptin; Mucolytics; Organophosphorus Compounds; Paraoxon; Pharmaceuticals; Protective Agents; Respiratory Agents; Respiratory Inhalant Products EN Tehran Iran Acetylcysteine Acetylcysteine Therapy Adipokines Amino Acids Antidotes Antioxidants Cysteine Drugs and Therapies Health and Medicine Intercellular Signaling Peptides and Proteins Leptin Mucolytics Organophosphorus Compounds Paraoxon Pharmaceuticals Protective Agents Respiratory Agents Respiratory Inhalant Products 480 480 1 04/17/23 20230421 NES 230421 2023 APR 21 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Drugs and Therapies - Antioxidants. According to news originating from Tehran, Iran, by NewsRx correspondents, research stated, "Exposure to paraoxon (POX) and leptin (LP) could cause an imbalance between oxidants and antioxidants in an organism, which can be prevented by introduction of exogenous antioxidants such as N-acetylcysteine (NAC). [Extracted from the article]

Published
2023

2. The Effect of Chronic Consumption of Paraoxon on Basal and Pentagastrin-Stimulated Gastric Acid and Pepsin Secretion in Rats.

Author

Rafsanjani, Fatemeh N., Ardakani, Zakieh V., Vahedian, Jalal, Moradi, Mehran, and Attar, Amir F.

Subjects
*METABOLITES, *INSECTICIDES, *ACETYLCHOLINESTERASE, *GASTRIC acid, *PEPSIN
Abstract

Background/Aims: Paraoxon, an organophosphate metabolite of the insecticide parathion inhibits the enzyme, acetylcholinesterase (Achase). Organophosphates affect the heart, visual system, nervous system and muscles. In this present study, we investigate the effects of the chronic consumption of paraoxon on gastric acid and pepsin secretion in N-mari rats. Materials and Methods: This study was performed from April 2003 to May 2004 in the Physiology department of Baghiatalah University of Medical Sciences, Tehran, Iran. It was performed on three groups of female N-mari rats (10/group) each weighing 200-250 g. The first group received 0.05 mg/kg/day paraoxon subcutaneously for one month. The second group received the same chronic doses of ethyl alcohol (96%) (solvent of paraoxon) and the third group (control) received no drugs. After tracheostomy and laparatomy, gastric secretions were collected with a tube via the duodenum. Pentagastrin (25 µg/kg, i.p.) was used as a gastric stimulator. Acid and pepsin secretions were measured by titration and the Anson method, respectively. The stages of the measurements were basal (first and second), stimulated and returned-basal. Results: Basal acid secretion in the paraoxon group was greater than those in the alcohol and control groups (14.61 ± 1.46, 7.18 ± 0.28 and 7.88 ± 0.26 µmol/15 min, respectively, P < 0.001)). Although pentagastrin-stimulated acid secretion in all the three groups was greater than that of the basal state, there were no significant differences among the three groups. Basal pepsin secretions in the paraoxon group were greater than those in the alcohol and control groups (2.97 ± 0.32, 1.19 ± 0.25 and 0.55 ± 0.06 µg/15 min, respectively). Pentagastrin-stimulated pepsin secretion in the paraoxon group was signifi cantly greater than those in the alcohol and control groups (3.22 ± 0.38, 2.22 ± 0.46 and 1.09 ± 0.66 µg/15 min, respectively, P < 0.001). Conclusion: Chronic exposure to paraoxon results in the increased secretion of gastric acid and pepsin. [ABSTRACT FROM AUTHOR]

Published
2007
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