Keywords: Tolerance; T regulatory cells EN Tolerance T regulatory cells N.PAG N.PAG 1 12/28/20 20210101 NES 210101 Several seminal events built on years of basic discoveries led to recognition of the critical role of a subset of T cells, termed regulatory T cells or Tregs, in controlling both immunity and tolerance. Cell Immunol. 358, 2020, 12 I. Janssens, N. Cools, Regulating the regulators: Is introduction of an antigen-specific approach in regulatory T cells the next step to treat autoimmunity? Cell Immunol. 358, 2020, 17 R.Y. Fu, CD4(+) T cells engineered with FVIII-CAR and murine Foxp3 suppress anti-factor VIII immune responses in hemophilia a mice. [Extracted from the article]