1. New tricyclic prezizaane sesquiterpenoids from agarwood.
- Author
-
Yang YL, Li W, Wang H, Yang L, Yuan JZ, Cai CH, Chen HQ, Dong WH, Ding XP, Jiang B, Mándi A, Kurtán T, Mei WL, and Dai HF
- Subjects
- Glycoside Hydrolase Inhibitors isolation & purification, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Sesquiterpenes isolation & purification, Thailand, alpha-Glucosidases, Glycoside Hydrolase Inhibitors pharmacology, Sesquiterpenes pharmacology, Thymelaeaceae chemistry, Wood chemistry
- Abstract
Ten new tricyclic prezizaane types sesquiterpenoids (1-10) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp. Their structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of the new prezizaenes 1, 2 and 4 was determined by single-crystal X-ray diffraction, while TDDFT-ECD method was applied for 6. Compounds 4 and 5 displayed significant inhibitory activities toward α-glucosidase with IC
50 values of 0.22 and 1.99 mM, respectively., (Copyright © 2019 Elsevier B.V. All rights reserved.)- Published
- 2019
- Full Text
- View/download PDF