1. Identification of hepatitis B virus genotype I in Thailand.
- Author
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Holzmayer V, Hance R, Defechereux P, Grant R, Kuhns MC, Cloherty G, and Rodgers MA
- Subjects
- China, DNA, Viral genetics, Hepatitis B Surface Antigens genetics, Hepatitis B virus genetics, Humans, Sequence Analysis, DNA, Sequence Deletion, Thailand, Genotype, Hepatitis B virology, Hepatitis B virus classification, Hepatitis B virus isolation & purification
- Abstract
The rare hepatitis B virus genotype I (HBV-I) classification includes complex A/G/C/U recombinants identified amongst the individuals from China, India, Laos, and Vietnam. Herein we report the first HBV-I specimen from Thailand, with detectable HBsAg despite a 10-amino-acid truncation. This HBV-I genome has a similar recombinant pattern to reference strains, including a C region that branches basal to references, suggesting a premodern era recombination event gave rise to HBV-I. With an average sequence divergence from other genotypes ranging from 7.66% (standard deviation [SD], 0.42%; C) to 14.27% (SD, 0.31%; H), this new genome supports the HBV-I classification as a unique genotype., (© 2018 Wiley Periodicals, Inc.)
- Published
- 2019
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