1. Human Campylobacteriosis in Southeast Asia: A Meta-Analysis and Systematic Review.
- Author
-
Wada, Y. and Abdul-Rahman, Z.
- Subjects
- *
CAMPYLOBACTER infections , *RANDOM effects model , *BACTERIAL diseases , *FOOD poisoning - Abstract
Campylobacteriosis is one of the most common bacterial infections in humans, and it is frequently associated with food poisoning. Here, we carried out a meta-analysis and systematic review in analysing the prevalence of Campylobacteriosis in Southeast Asia (SEA) Databases such as, PubMed, Scopus and Google Scholar were searched. Data was extracted by two independent reviewers and the results were reviewed by a third. Two reviewers independently assessed the study protocol using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist and the study quality using the Joanna Briggs Institute (JBI) critical appraisal checklist for prevalence data. Comprehensive meta-analysis version 2 was used for the meta-analysis. The random effect model was used, publication bias was assessed using the Eggers test, funnel plot and the Trim-and-Fill method. Between-study heterogeneity was assessed, the sources were analysed using the leave-one-out meta-analysis, subgroup analysis, and meta-regression. Fifty-one studies met the eligibility criteria and were therefore added to the final meta-analysis. Of the 83107 isolates tested in the included studies, 4118 were Campylobacter. The pooled prevalence of campylobacteriosis in SEA was estimated at 7.8% (95% CI; 5.8โ10.4%; I2 = 98.708%; P < 0.001). Between-study variability was high (t2 = 1.254; heterogeneity I2 = 98.708% with heterogeneity chi-square (Q) = 3871.349, df = 50, and P < 0.001). The funnel plot showed bias which was confirmed by Egger's test (t -value = 0.94252; P = 0.35055), and estimates from the leave-one-out forest plot did not affect the pooled prevalence. Nine studies were missed and fall at the right side of the pooled estimate by the Trim-and-Fill method. Pooled prevalence of campylobacteriosis in adult and children were 3.0% (CI=1.9-4.8%) and 7.1% (CI=5.1-9.8%) respectively. More studies were reported in Thailand with a prevalence of 13.3% (CI; 9.6-18.2%). Culture and stool were utilized most in the detection and sampling respectively. Country (P = 0.0014) and study population (P = 0.0000) were sources of heterogeneity among the variables. Campylobacteriosis needs to be monitored more closely in SEA. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF