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Inter‐regional trade can potentially extend the management of resources and induced ecological environmental impacts beyond a region's territory along supply chains. We combined environmental‐extended multi‐regional input–output analysis and ecosystem services value (ESV) assessment, to identify the remote connections of construction land use and the induced ecosystem services potential loss in inter‐provincial trade in China from 2007 to 2017. The findings indicated that the virtual construction land flow increased by 0.774 million ha in the eight regions of China during 2007–2017. The Northeast and the Northwest were net exporters while most of the inflow areas were in the more developed areas such as Beijing–Tianjin–Hebei and the Yangtze River Delta. The net regional flow of ecosystem service potential loss (ESPL) in China increased by 352.64 billion yuan. The spatial heterogeneity of ESV in each province led to differences in the inter‐sectoral or inter‐regional flow characteristics of ESPL from embodied construction land use. The outflow areas of ESPL were mostly located in the old industrial bases of the Northeast and Northern Coast, which sacrificed their local ecological service value to meet the development needs of Southern Coast, Southwest China and Beijing–Tianjin. The research results help to clarify ecological and environmental responsibility, improve ecological compensation mechanisms and formulate scientific policies for coordinated protection of ecosystem services. [ABSTRACT FROM AUTHOR]

To examine the association between blood cholesterol concentrations and Alzheimer's disease (AD) in the Chinese elderly. A case-control study was implemented between November 2011 and November 2017. Elderly patients aged ≥ 55 years with (n = 117) and without AD (control participants; n = 117) were recruited from the Neurology Central Hospital of Tianjin, China. The associations between AD and blood parameters were assessed using multiple binary logistic regression analyses adjusted for multiple covariates. Higher serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels and lower serum high-density lipoprotein cholesterol (HDL-C) levels associated with AD risk in the models adjusted for (1) age, sex and education; and (2) further adjusted for body mass index, smoking status, stroke, hypertension, type 2 diabetes mellitus and heart disease. Increased serum TC and LDL-C levels and lower HDL-C levels were independently associated with the risk of AD. [ABSTRACT FROM AUTHOR]

Orthostatic hypotension (OH) is one of the most important autonomic features of multiple system atrophy (MSA). This study was established to confirm the correlation between lipid levels and OH in MSA. A total of 580 patients with probable or possible MSA from neurological wards in six hospitals in Tianjin, Beijing, Hebei Province, and Henan Province, China, were included in this study. The tilt test or stand test was used to assess the severity of OH. Lipid contents, including total cholesterol, low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol (HDL-C), and triglyceride were evaluated. Serum levels of total cholesterol, LDL-C, and triglyceride in MSA-OH patients were significantly lower than those in MSA without OH. The risks of OH were significantly higher in the lowest quartiles of triglyceride and LDL-C than in the highest quartiles, after adjusting for confounders (OR = 2.17, 95% CI: 1.23–3.82, P = 0.008 and OR = 2.02, 95% CI: 1.16–3.47, P = 0.012). The risk of severe OH was significantly higher in the lowest quartile and the second quartile of triglyceride than in the highest quartile after adjusting for confounders (OR = 2.16, 95% CI: 1.20–3.87, P = 0.010 and OR = 2.25, 95% CI: 1.24–4.07, P = 0.007). Moreover, the risk of OH was significantly higher in the lowest quartile, and the third quartile of TC than in the highest quartile after adjusting for confounders (OR = 2.04, 95% CI: 1.18–3.52, P = 0.010 and OR = 2.06, 95% CI: 1.19–3.56, P = 0.010). Low levels of TC, LDL-C, and triglyceride increased the risk of OH in MSA. A low level of triglyceride predicted severe OH in MSA. • Blood lipid levels were associated with orthostatic hypotension in multiple system atrophy patients. • Low levels of TC, LDL-C, and triglyceride increased the risk of OH in MSA patients. • Low triglyceride was found to be an independent risk factor for severe OH in MSA. [ABSTRACT FROM AUTHOR]