1. Bioactive Nortriterpenoids from Schisandra grandiflora.
- Author
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Xiao WL, Gong YQ, Wang RR, Weng ZY, Luo X, Li XN, Yang GY, He F, Pu JX, Yang LM, Zheng YT, Lu Y, and Sun HD
- Subjects
- Anti-HIV Agents chemistry, Crystallography, X-Ray, Drug Screening Assays, Antitumor, Drugs, Chinese Herbal chemistry, Humans, Molecular Conformation, Molecular Structure, Tibet, Triterpenes chemistry, Anti-HIV Agents isolation & purification, Anti-HIV Agents pharmacology, Drugs, Chinese Herbal isolation & purification, Drugs, Chinese Herbal pharmacology, HIV-1 drug effects, Schisandra chemistry, Triterpenes isolation & purification, Triterpenes pharmacology
- Abstract
Three new nortriterpenoids, schigrandilactones A-C (1-3), along with eight known compounds, were isolated from an organic solvent extract of Schisandra grandiflora. Compounds 1 and 2 feature a spirocyclic moiety in their structures, and compound 3 was characterized with a new oxygenated pattern. The relative configurations of 1 and 3 were determined through single-crystal X-ray experiments. In addition, compounds 1 and 2 displayed cytotoxic activity against two human cancer cell lines, and compound 3 showed anti-HIV-1 inhibition in infected C8166 cells.
- Published
- 2009
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