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In China and other countries, many highway projects are built in extensive and high-altitude flat areas called plateaus. However, research on how the materialisation of these projects produce a series of ecological risks in the landscape is very limited. In this research, a landscape ecological risk analysis model for high-altitude plateaus is proposed. This model is based on the pattern of land uses of the surrounding area. Our study includes buffer analysis, spatial analysis, and geostatistical analysis. We apply the model to the Qumei to Gangba highway, a highway section located in the southeast city of Shigatse at the Chinese Tibet autonomous region. Through global and local spatial autocorrelation analysis, the spatial clustering distribution of ecological risks is also explored. Overall, our study reveals the spatial heterogeneity of ecological risks and how to better mitigate them. According to a comparison of the risk changes in two stages (before and after the highway construction), the impact of highway construction on the ecological environment can be comprehensively quantified. This research will be of interest to construction practitioners seeking to minimize the impact of highway construction projects on the ecological environment. It will also inform future empirical studies in the area of environmental engineering with potential affection to the landscape in high-altitude plateaus. [ABSTRACT FROM AUTHOR]