1. The regulating effect of Tibet Opuntia ficus-indica (Linn.) Mill. polysaccharides on the intestinal flora of cyclophosphamide-induced immunocompromised mice.
- Author
-
Liu, Zhendong, Zhang, Jinchao, Zhao, Qian, Wen, Aomei, Li, Liang, and Zhang, Yu
- Subjects
- *
OPUNTIA ficus-indica , *POLYSACCHARIDES , *BOTANY , *LEUCOCYTES , *GUT microbiome , *PSYCHONEUROIMMUNOLOGY - Abstract
The stem of Opuntia species, a traditional medicinal plant, is widely used as food and functional raw material because of its rich polysaccharide content. There have been many studies on the immune function of polysaccharides from Opuntia stem, but only few have examined this function with respect to intestinal microbes. In this study, the effects of different concentrations of Opuntia stem polysaccharides on the immunity and intestinal microflora of cyclophosphamide (CTX)-induced immunocompromised mice were explored. The results showed that Tibet Opuntia ficus-indica (Linn.) Mill. polysaccharides (ODPs) could effectively increase the white blood cells (WBC) count index of mice and improve their thymus and spleen indices, while effectively promoting the secretion of IL-4, IL-1β, TNF-α and IFN-γ, with these effects being dependent on the concentration of crude polysaccharides. The intake of ODPs significantly regulated the relative abundance of Lactobacillus, Bacteroides and Akkermansia, and the new dominant intestinal bacterial species were Deferribacteres, Actinomycetes, Firmicutes, Tenericutes, Actinomycetes and Pasteurella. In addition, the ODPs could effectively enhance the metabolic level of lysine synthesis and decomposition, regulate the gene expression level after immune disorders, and enhance the overall health of the immunodeficient mice. [Display omitted] • The Tibet Opuntia ficus-indica (Linn.) Mill. polysaccharides (ODPs) have unique properties and biological activity. • The Tibet ODPs have the effect of enhancing the overall health of immunodeficient mice. • The Tibet ODPs can be used as prebiotics. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF