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The southeastern periphery of the Tibetan Plateau (SEPTP) was hit by an extraordinarily severe drought in the autumn of 2009. Overall, the SEPTP has been gripped by a sustained drought for six consecutive years. To better understand the physical causes of these types of severe and frequent droughts and thus to improve their prediction and enhance the ability to adapt, many research efforts have been devoted to the disastrous droughts in the SEPTP. Nonetheless, whether the likelihood and strength of the severe droughts in the SEPTP, such as that in the autumn of 2009, have been affected by anthropogenic climate change remains unknown. This study first identifies the atmospheric circulation regime responsible for the SEPTP droughts and then explores how human-induced climate change has affected the severe droughts in the SEPTP. It is found that the drought conditions in the SEPTP have been driven by the Indian-Pacific warm pool (IPWP) sea surface temperature (SST) through strengthening of the local Hadley circulation and anomalously cyclonic motion over the South China Sea. Ensemble simulations of climate models demonstrate a robust increase in the dry and warm meteorological conditions seen during the 2009 SEPTP autumn drought due to anthropogenic global warming. Given that warming is expected to continue into the future, these results suggest that it is likely that drought conditions will become more common in the SEPTP. [ABSTRACT FROM AUTHOR]