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Determination of the limit angle at the Manisa-Soma-Eynez coal field, a major coal production area in Turkey, is difficult because of the presence of a landslide caused by the waste from a neighboring open-pit site being dumped over the underground mine at the Soma-Eynez basin. In fact, it is not possible to determine the effect of extraction on the surface from field studies. Thus, in order to determine the limit angle, in-situ subsidence measurements, geophysical measurements, rock-based tests in the laboratory and the data obtained from a physical model have supported numerical modeling studies. The software, LAMODEL, used for the numerical modeling was developed by National Institute for Occupational Safety and Health (NIOSH), and is based on the Boundary Element Method. The results obtained from modeling have been found to be compatible with other studies and as a result the limit angle has been determined. [Copyright &y& Elsevier]

Monogenic immune dysregulation diseases (MIDD) are caused by defective immunotolerance. This study was designed to increase knowledge on the prevalence and spectrum of MIDDs, genetic patterns, and outcomes in Middle East and North Africa (MENA). MIDD patients from 11 MENA countries (Iran, Turkey, Kuwait, Oman, Algeria, Egypt, United Arab Emirates, Tunisia, Jordan, Qatar, and Azerbaijan) were retrospectively evaluated. 343 MIDD patients (58% males and 42% female) at a median (IQR) age of 101 (42-192) months were enrolled. The most common defective genes were LRBA (23.9%), LYST (8.2%), and RAB27A (7.9%). The most prevalent initial and overall manifestations were infections (32.2% and 75.1%), autoimmunity (18.6% and 41%), and organomegaly (13.3% and 53.8%), respectively. Treatments included immunoglobulin replacement therapy (53%), hematopoietic stem cell transplantation (HSCT) (14.3%), immunosuppressives (36.7%), and surgery (3.5%). Twenty-nine (59.2%) patients survived HSCT. Along with infectious complications, autoimmunity and organomegaly may be the initial or predominant manifestations of MIDD., Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare that are relevant to the content of this article., (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)