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1. High risk subgroup of acute myelomonocytic leukemia (AMML) with orbito-ocular granulocytic sarcoma (OOGS) in Turkish children. Retrospective analysis of clinical, hematological, ultrastructural and therapeutical findings of thirty-three OOGS.

Author

Cavdar AO, Babacan E, Gözdaşoğlu S, Kilicturgay K, Arcasoy A, Cin S, Ertem U, and Erten J

Subjects
Adolescent, Child, Child, Preschool, Eye ultrastructure, Eye Neoplasms drug therapy, Eye Neoplasms mortality, Female, Humans, Leukemia, Myeloid drug therapy, Leukemia, Myeloid mortality, Leukemia, Myelomonocytic, Acute drug therapy, Leukemia, Myelomonocytic, Acute mortality, Male, Orbital Neoplasms drug therapy, Orbital Neoplasms mortality, Organelles ultrastructure, Retrospective Studies, Risk Factors, Turkey, Eye Neoplasms pathology, Leukemia, Myeloid pathology, Leukemia, Myelomonocytic, Acute pathology, Orbital Neoplasms pathology
Abstract

Thirty-three patients presenting with orbito-ocular granulocytic sarcoma (OOGS) and acute myelomonocytic leukemia (AMML) were diagnosed in Turkish children from 1963 to 1983. OOGS, characterized by exophthalmos, chemosis and orbital masses, was observed in 33 (27.2%) of 121 AML patients compared with 41 children of AMML without ophthalmic tumors during the same period. Eye tumor and bone marrow aspirates were also studied under light and electron microscopies. The comparison of the hematological parameters did not indicate any statistical difference between the groups. Despite similar chemotherapy regimens administered to all patients, the mean survival time was 8.7 months in the OOGS group, which is significantly shorter compared to those without OOGS (28.6 months) (p less than 0.01). These cases may be classified as a "high risk" subgroup of childhood AMML.

Published
1989
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