1. Trends in Causative Organisms and Antimicrobial Resistance in Late-onset Neonatal Sepsis.
- Author
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Özkavaklı, Ayberk, İmamoğlu, Ebru Yalın, Önder, Neslihan, İmamoğlu, Serhat, and Ovalı, Hüsnü Fahri
- Subjects
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ANTIBIOTICS , *LEUKOCYTE count , *RISK assessment , *MICROBIAL contamination , *CROSS infection , *CANDIDA , *MICROBIAL sensitivity tests , *DRUG resistance in microorganisms , *NEONATAL intensive care units , *HOSPITAL care , *NEONATAL intensive care , *RETROSPECTIVE studies , *STAPHYLOCOCCUS aureus , *AMPICILLIN , *GRAM-negative aerobic bacteria , *DESCRIPTIVE statistics , *MANN Whitney U Test , *CHI-squared test , *VANCOMYCIN , *SERRATIA , *ESCHERICHIA , *BACTERIAL diseases , *STAPHYLOCOCCUS , *LINEZOLID , *PEPTIDE antibiotics , *CEPHALOSPORINS , *COMPARATIVE studies , *DATA analysis software , *NEONATAL sepsis , *DISEASE incidence , *GRAM-positive bacteria , *KLEBSIELLA , *C-reactive protein , *CEREBROSPINAL fluid , *GRAM-negative bacteria , *PSEUDOMONAS ,MORTALITY risk factors - Abstract
Objective: The aim of this study was to evaluate the antibiotic resistance of microorganisms isolated in cases of culture-positive nosocomial late-onset neonatal sepsis in the neonatal intensive care unit. Materials and Methods: Infants admitted to our neonatal intensive care unit between October 2015 and June 2022 were retrospectively screened. A total of 458 different cultures from 386 sepsis incidents in 250 infants were analyzed. Results: Over an 8-year period, 407 cases of culture-positive nosocomial late-onset neonatal sepsis were reviewed in a total of 4244 infants. Twenty-one cases were excluded due to insufficient data. The incidence of culture-positive nosocomial sepsis was 6.3%. Coagulase-negative Staphylococcus and Staphylococcus aureus were the most common gram-positive bacteria found in cultures. Resistance to ampicillin and cephalosporin treatments was high, while resistance to vancomycin, teicoplanin, and linezolid was low. Klebsiella spp. were the most frequent gram-negative bacteria isolated in cultures and showed high resistance to non-carbapenembased regimens. The only fungal microorganisms isolated in cultures were Candida spp., which had a high mortality rate despite their low resistance profile. The mortality rate due to nosocomial sepsis was 19.6%. Conclusion: Our study demonstrated that microorganisms and their antibiotic resistance profiles changed over time in the newborn intensive care unit. Gram-negative pathogens exhibited high antibiotic resistance, while fungi had high mortality rates. It is essential to adjust empirical antibiotic regimens for nosocomial sepsis based on thorough surveillance. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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