Search

Objectives: The aim of this study was to evaluate the impact of obesity on the treatment response to secukinumab and drug survival rate in patients with ankylosing spondylitis (AS). Methods: We performed an observational cohort study that included AS patients based on the biological drug database in Turkey (TURKBIO) Registry between 2018 and 2021. The patients were divided into three groups: normal [body mass index (BMI) < 25 kg/m2], overweight (BMI: 25–30 kg/m2), and obese (BMI ≥ 30 kg/m2). Disease activity was evaluated at baseline, 3, 6, and 12 months. Drug retention rates at 12 months were also investigated. Results: There were 166 AS patients using secukinumab (56.6% male, mean age: 44.9 ± 11.6 years). The median follow-up time was 17.2 (3–33.2) months. Forty-eight (28.9%) patients were obese. The mean age was higher in the obese group than in others (P = .003). There was no statistically significant difference in Bath Ankylosing Spondylitis Disease Activity Index 50, Assessment of SpondyloArthritis international Society 20 (ASAS20), ASAS40, Ankylosing Spondylitis Disease Activity Score (ASDAS) low disease activity, and ASDAS clinically important improvement responses between the three groups at 3, 6, and 12 months, although they were numerically lower in obese patients. Drug retention rates at 12 months were similar in all groups (P > .05). Conclusions: This study suggested that obesity did not affect secukinumab treatment response and drug retention in AS patients. [ABSTRACT FROM AUTHOR]

The aim of this study was to examine the real-life efficacy and safety of secukinumab for psoriasis (PsO) along with the factors that could have an effect on clinical response. Data in the charts of 121 patients with chronic PsO who were initiated secukinumab treatment between May-2018 and April-2020 with an observation period of up to 52 weeks were retrospectively analyzed. Demographic and clinical characteristics of patients, Psoriasis Area and Severity Index (PASI) scores and side effects were evaluated. A 75%, 90%, and 100% reduction in the baseline PASI score was observed in 84.3%, 68.6%, and 18.2% of patients at week 16, respectively. Obesity and previous biologic experience were important predictive factors for PASI 75 response at week 16. CRP levels, previous biological experience and age at PsO onset are found to be important factors in defining the need for updosing. Side-effect rates (9.7%) were not higher among patients with concomitant medications (13.6%) and dose escalation (13.3%). Our results are in line with the efficacy and safety profiles of secukinumab in PsO reported previously. Dose escalation and the addition of concomitant medications may increase response rates. [ABSTRACT FROM AUTHOR]

Background/aim: PSORTAKSIS is a psoriasis registry, which is used for follow-up of patients in Kayseri City Education and Research Hospital, Dermatology Clinic since 2016 in Turkey. PSORTAKSIS includes demographic data, follow-up clinical findings, laboratory output, and treatment information of patients. Here, drug survivals of biologic therapeutics (BT) according to three-year data of PSORTAKSIS will be presented. Materials and methods: Drug survival of BT in PSORTAKSIS was analyzed from 2016 to March 2019. Results: 158 patients (111 of them BT-naive) with psoriasis under BT were enrolled in the current study. Drug survival analysis of patients with ongoing BT (158 treatment periods) revealed mean survival time as 15.49 months for ustekinumab, 15.37 months for adalimumab, 14.00 months for etanercept, 5 months for infliximab, and 4.59 months for secukinumab. The differences between drug survivals of BT were statistically significant (log-rank test, χ2 = 79.915, p < 0.0001). Age of onset was found to be the only independent risk factor of drug survival according to regression analysis (p = 0.029). Conclusion: As a conclusion, drug survival of UST was significantly higher than that of TNF-alpha inhibitors and SEC in the treatment of psoriasis. This study revealed that among predictors, age at disease onset may influence drug survival. [ABSTRACT FROM AUTHOR]

Background and Design: Several randomized clinical trials demonstrated the safety and efficacy of secukinumab in the systemic treatment of moderate-severe psoriasis; however, real-life data is limited. Thus, this study aimed to assess the efficacy and safety of secukinumab in patients with psoriasis. Materials and Methods: In this study, 32 patients treated with secukinumab were retrospectively reviewed. The efficacy of secukinumab was evaluated as psoriasis area and severity index (PASI) 50, 75, and 90 response rates at 16., 24., and 36. weeks, respectively. Side effects of secukinumab treatment were recorded. Results: The mean PASI of 32 patients before treatment was 12.38±6.49, which decreased to 1.96, 1.85, and 3.01, after 16, 24, and 36 weeks, respectively. At 16 weeks of treatment, 83.3% of patients reached PASI 50, 70.0% had PASI 75, and 50.0% had PASI 90 response rates. At 16, 24, and 36 weeks, PASI 50, 75, and 90 responses were generally higher in patients naive to biologic than the non-naive; however, differences were not statistically significant (p>0.05). Secukinumab was discontinued in 7 (21.9%) patients during the treatment. Of the 7 patients, 5 (15.6%) patients failed to respond to secukinumab and 2 (6.2%) developed various side effects. Oral candidiasis was observed in 4 (12.5%) patients, which was the most common side effect of secukinumab treatment. Conclusion: Secukinumab is an effective and safe treatment option in patients with psoriasis. The secukinumab efficacy in clinical practice is higher in patients naive to biologic. [ABSTRACT FROM AUTHOR]

Secukinumab may be a safety option for patients with psoriasis and hepatitis B virus (HBV) infection because of its treatment mechanism. Two patients with chronic HBV who had used tenofovir disoproxil 245 mg per day were suffering from psoriasis. For one, on July 31, 2019 treatment with standard dose secukinumab was started and for another on January 20, 2020. Although on March 11, 2020 Coronavirus disease-2019 (COVID-19) pandemic started in Turkey, we didn't stop secukinumab treatments of our patients. Based on the start of treatment of secukinumab of our 50-year-old patient, after eight weeks Psoriasis Area Severity Index (PASI) 90 response and after 15 weeks PASI 100 response was reached and PASI 90 response was obtained in our 35-year-old patient after five weeks and PASI 100 response was reached after 18 weeks after starting secukinumab. Secukinumab treatments of our patients are going on. Further long-term studies and case reports are needed to validate the safety and efficacy of secukinumab in patients with HBV. Our cases were deemed worthy of presentation because they were the first reported cases with psoriasis and HBV infection used secukinumab and tenofovir disoproxil in COVID-19 pandemic. [ABSTRACT FROM AUTHOR]