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Aim: First-degree relatives of patients who have had an acute myocardial infarction prior to age of 55 years have 2-7 times the risk that their peers have. The aim of this study was to investigate some haemostatic and inflammatory markers, in children whose parents had early onset (<55 years) coronary artery disease (CAD), and whether those markers were effective to show CAD risk. Material and Method: This prospective study was performed in Pediatric Cardiology Department of Istanbul Medical Faculty with the permission of Local Ethic Committee of Faculty. Forty-three healthy children, whose parents had early onset CAD, were matched with age and sex pairs and tissue factor (TF), free and total tissue factor pathway inhibitor (TFPI), fibrinogen, von Willebrand factor (vWF) and high sensitive CRP (hsCRP) were analyzed in both groups. SPSS 10 were performed for analyzing data using Mann-Whitney U and student-t tests. Results: Study group had higher vWF than control group (116.3±52.2 vs. 86.8±41.4 ng/mL), p<0.05). Tissue factor, total and free TFPI, fibrinogen and hsCRP were not statistically different between the two groups. Conclusions: Although premature CAD is known to have a particularly strong genetic component, this study showed that haemostatic and inflammatory markers except vWF are not independent risk factors of family history of early onset CAD. [ABSTRACT FROM AUTHOR]