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Objective: Introduction: We present the results of the combined method of treatment and prevention of miscarriage in women with a multiple pregnancy and a high risk of the threat of terminating the pregnancy because of using the obstetric unloading pessaries, combined with micronized progesterone. The efficiency of this method of treatment is evidenced by the rapid elimination of clinical symptoms of threatened abortion, accelerating the regression of ultrasound markers, reducing the number of complications in of pregnant women and reducing the time of their stay in hospital. The aim: To evaluate the effectiveness of the handling the obstetric pessary in combination with micronized progesterone at women with multiple pregnancies and a high risk of miscarriage., Patients and Methods: Materials and methods: We analyzed 120 cases of multiple pregnancies with signs of miscarriage within the terms from 16 to 28 weeks. The first group of surveyed were 40 pregnant women with twins and signs of miscarriage, who in the scheme of treatment and prophylactic measures were proposed to use the unloading obstetric pessaries in combination with continuous therapy by natural micronized progesterone until 36 weeks of pregnancy. The second group included 40 pregnant women with twins, who were laid seam on the cervix because of cervical incompetence and were applied short-term courses of therapy by gestagens. The control group comprised 40 pregnant women with twins at the age of 16-28 weeks of pregnancy who were conducted the therapy about the threat of miscarriage according to the current clinical protocols (Order of the Ministry of Health of Ukraine No. 624). It was carried out the analysis of the course of pregnancy, childbirth, the postpartum period and the state of neonatal adaptation in the surveyed groups., Results: Results: In the first group, urgent childbirth occurred in 34 (85%) cases, in group II in 29 (72.5%) cases, in control group - 25 (62.5%) cases. Cesarean delivery was performed in 7 (17.5%) of Group I pregnant women, in 9 (22.5%) of Group II patients and in 11 (27.5%) in the pregnant group. When studying the state of neonatal adaptation of newborns in the examined groups, the following results were obtained. The average weight of the newborns in group I was 3245 ± 280 g, in group II 2865 ± 365 g, in the control group - 2975 ± 325 g (p> 0.05). The evaluation of the state of newborns on the Apgar scale, respectively at the 1st and 5th minutes, was respectively: in newborns of the I group, 7.5 ± 1.4 and 8.4 ± 1.3 points, in group II - 7.3 ± 1.6 and 8.2 ± 1.1 points, in the control group - 7.2 ± 1.6 and 8.6 ± 1.2 (р 1-р 2> 0.05)., Conclusion: Conclusions: Comprehensive prophylaxis of non-pregnancy in multiple pregnancies, combining the use of a traumatic cardiac cervix with the help of unloading obstetric pussies with progesterone preparations, allows prolonging pregnancy, preventing the development of prematurity, contributes to the improvement of perinatal indicators.