1. Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration.
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Austin-Zimmerman, Isabelle, Levey, Daniel F., Giannakopoulou, Olga, Deak, Joseph D., Galimberti, Marco, Adhikari, Keyrun, Zhou, Hang, Denaxas, Spiros, Irizar, Haritz, Kuchenbaecker, Karoline, McQuillin, Andrew, Concato, John, Buysse, Daniel J., Gaziano, J. Michael, Gottlieb, Daniel J., Polimanti, Renato, Stein, Murray B., Bramon, Elvira, and Gelernter, Joel
- Subjects
SLEEP duration ,GENOME-wide association studies ,HERITABILITY ,GENETIC correlations ,LOCUS (Genetics) ,LINKAGE disequilibrium ,LIFE expectancy - Abstract
Sleep duration has been linked to a wide range of negative health outcomes and to reduced life expectancy. We present genome-wide association studies of short (≤ 5 h) and long (≥ 10 h) sleep duration in adults of European (N = 445,966), African (N = 27,785), East Asian (N = 3141), and admixed-American (N = 16,250) ancestry from UK Biobank and the Million Veteran Programme. In a cross-population meta-analysis, we identify 84 independent loci for short sleep and 1 for long sleep. We estimate SNP-based heritability for both sleep traits in each ancestry based on population derived linkage disequilibrium (LD) scores using cov-LDSC. We identify positive genetic correlation between short and long sleep traits (r
g = 0.16 ± 0.04; p = 0.0002), as well as similar patterns of genetic correlation with other psychiatric and cardiometabolic phenotypes. Mendelian randomisation reveals a directional causal relationship between short sleep and depression, and a bidirectional causal relationship between long sleep and depression. Here, the authors investigate the genetic basis of short (≤ 5 h) and long (≥ 10 h) sleep duration, identifying 84 independent significant risk loci for short sleep and 1 locus for long sleep, and causal associations between sleep and psychiatric traits. [ABSTRACT FROM AUTHOR]- Published
- 2023
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