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Copyright of Canadian Journal of Veterinary Research / Revue Canadienne de Recherche Vétérinaire is the property of Canadian Veterinary Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Presents an obituary of economist Francis Seton of Great Britain. Educational background; Family background; Work experience.

Recounts the story of how classic hemophilia was transmitted in three generations of the descendants of Victoria, the late Queen of Great Britain. Hemophiliac descendants of Victoria; Hemophilia carrier testing and prenatal diagnosis; Postage stamps depicting Queen Victoria and other hemophiliacs.

The article presents a profile of Transvaal, Africa in 1899. Transvaal has an area of 119,139 square miles and its population is approximately 800,000. Its white population consists of the Boers and Uitlanders. By steamer, Transvaal is 9,000 miles away from Boston, Massachusetts and 3,000 from England. It offers information on Stephanus Johannes Palus Kruger and the colonization attempt of Great Britain.

The article focuses on the laurel crowns being bestowed to poets in Great Britain. The death of William Wordsworth raised concerns over the need to appoint a successor to him. The poet laureate is a custom in Greece on the occasion of musical contests in which a successful author is publicly crowned. The Versificator Regis of Henry III, King of England received an annual grant of 100 shillings.

The article traces the origins of the opium trade in China, where the prevalence of smoking the drug had become unprecedented. The bulk transport of the substance into the country through vessels was inaugurated by the British East India company in 1773. After the Opium War with Great Britain, through the Treaty of Nanking in 1842, five ports were open to the trade, and by 1858 all ports were open. The properties of opium as a poppy extract are discussed in the latter part of the article.

Canine Inflammatory Bowel Disease (IBD) is considered a multifactorial disease caused by complex interactions between the intestinal immune system, intestinal microbiota and environmental factors in genetically susceptible individuals. Although IBD can affect any breed, German shepherd dogs (GSD) in the UK are at increased risk of developing the disease. Based on previous evidence, the aim of the present study was to identify single nucleotide polymorphisms (SNPs), which may confer genetic susceptibility or resistance to IBD using a genome-wide association study (GWAS). Genomic DNA was extracted from EDTA blood or saliva samples of 96 cases and 98 controls. Genotyping of cases and controls was performed on the Canine Illumina HD SNP array and data generated was analyzed using PLINK. Several SNPs and regions on chromosomes 7,9,11 and 13 were detected to be associated with IBD using different SNP-by-SNP association methods and FST windows approach. Searching one Mb up-and down-stream of the most significant SNPs, as identified by single SNP analysis as well as 200Kb before and after the start and the end position of the associated regions identified by FST windows approach, we identified 63 genes. Using a combination of pathways analysis and a list of genes that have been reported to be involved in human IBD, we identified 16 candidate genes potentially associated with IBD in GSD., Competing Interests: We have the following interests: This study was funded in part by Laboklin GmBH. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.