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The Western Channel Observatory (WCO) comprises a series of pelagic, benthic and atmospheric sampling sites within 40 km of Plymouth UK, which have been sampled by the Plymouth Institutes on a regular basis since 1903. This longevity of recording and the high frequency of observations provide a unique combination of data; for example temperature data were first collected in 1903 and the reference station L4 has been sampled on a weekly basis since 1988 where nearly 400 planktonic taxa have been enumerated. While the component datasets have been archived, here we provide the first summary database bringing together a wide suite of the observations. This provides monthly average values of some of the key pelagic and benthic measurements for the inshore site L4 (50° 15.00' N, 4° 13.02' W approx depth 55 m), the offshore site E1 (50° 02.00' N, 4° 22.00' W approx depth 75 m) and the intermediate L5 site (50° 10.80' N 4° 18.00' W approx depth 58 m. In brief, the data include: water temperature (from 1903); macronutrients (from 1934); dissolved inorganic carbon and total alkalinity (from 2008); methane and nitrous oxide (from 2011); chlorophyll a (from 1992); HPLC-derived pigments (from 1999); <20 µm plankton by flow cytometry including bacteria (8 functional groups from 2007); phytoplankton by microscopy (6 functional groups from 1992); microplankton and mesozooplankton from FlowCam (6 groups from 2012), Noctiluca sp. dinoflagellate (from 1997); mesozooplankton by microscopy (8 groups from 1988); Calanus helgolandicus egg production rates (from 1992); fish larvae from Young Fish Trawl survey (4 groups from 1924); benthic macrofauna (4 groups from 2008); demersal fish (19 families from 2008); blue shark, Prionace glauca (from 1958); 16S alpha diversity for sediment and water column (from 2012). These data have varying coverage in time and depth resolution. The metadata tables describe each data set, provide pointers to the source data and other related Western Channel Observatory data sets and outputs not compiled here. We provide summaries of the main trends in seasonality and some major, climate related shifts that have been revealed over the last century. The data are available from Data Archive for Seabed Species and Habitats (DASSH) via the link http://doi.org/10.17031/645110fb81749 (McEvoy and Atkinson, 2023). Making the data fully accessible and including units of both abundance and biomass will stimulate a variety of uptakes. These may include uses as an educational resource for projects, for models and budgets or for analysis of seasonality and long-term change in a coupled benthic-pelagic system and for supporting UK and Northeast Atlantic policy and management. [ABSTRACT FROM AUTHOR]

We describe and evaluate historical simulations which use the third Hadley Centre Global Environment Model in the Global Coupled configuration 3.1 (HadGEM3‐GC3.1) model and which form part of the UK's contribution to the sixth Coupled Model Intercomparison Project, CMIP6. These simulations, run at two resolutions, respond to historically evolving forcings such as greenhouse gases, aerosols, solar irradiance, volcanic aerosols, land use, and ozone concentrations. We assess the response of the simulations to these historical forcings and compare against the observational record. This includes the evolution of global mean surface temperature, ocean heat content, sea ice extent, ice sheet mass balance, permafrost extent, snow cover, North Atlantic sea surface temperature and circulation, and decadal precipitation. We find that the simulated time evolution of global mean surface temperature broadly follows the observed record but with important quantitative differences which we find are most likely attributable to strong effective radiative forcing from anthropogenic aerosols and a weak pattern of sea surface temperature response in the low to middle latitudes to volcanic eruptions. We also find evidence that anthropogenic aerosol forcings play a role in driving the Atlantic Multidecadal Variability and the Atlantic Meridional Overturning Circulation, which are key features of the North Atlantic ocean. Overall, the model historical simulations show many features in common with the observed record over the period 1850–2014 and so provide a basis for future in‐depth study of recent climate change. Plain Language Summary: Historical simulations, which successfully reproduce features of the observed climate from the end of the preindustrial period to the near‐present day, contribute to our understanding of the underlying mechanisms that drive or influence climate variability and climate change. The historical simulations described in this paper use the third Hadley Centre Global Environment Model in the Global Coupled configuration 3.1 model. These simulations form part of the UK's contribution to the sixth Coupled Model Intercomparison Project. We assess various aspects of the historical climate system in our simulations against observations. This includes the evolution of global mean surface temperature, ocean heat content, sea ice extent, ice sheet mass balance, permafrost extent, snow cover, North Atlantic sea surface temperature and circulation, and decadal precipitation. The key findings include (a) that the model global mean surface temperature broadly follows the observed record, with a few quantitative differences, and (b) that the ocean circulation and sea surface temperatures of the North Atlantic are likely influenced by historical forcings. In general, the simulations respond to historically evolving influences in a similar manner to the observed world. Therefore, these simulations contribute, as part of the wider CMIP6 multimodel effort, to the understanding of the causes of observed climate change since 1850. Key Points: We describe and evaluate the UK's CMIP6 historical simulationsWe identify drivers of the modeled global temperature evolution and compare with the observed recordWe find that anthropogenic aerosol forcings influence the simulation of North Atlantic ocean variability [ABSTRACT FROM AUTHOR]

Despite increasing interest in child sexual abuse occurring in organisations, the perpetration of such abuse by females is largely ignored. This study examined situational factors in 136 cases of sexual abuse perpetrated by women working with children in the UK, Canada and the USA between 2000 and 2016. Qualitative and quantitative content analysis of court reports, professional regulator decisions, media reports and an online sentencing database was used, findings indicating that situational and contextual factors are highly relevant in perpetration. Much abuse occurs away from the organisational environment, particularly in perpetrators' homes and cars, and in virtual environments. However, it also occurs within organisations, generally in unsupervised areas, outside of operating hours and often during mentoring/tutoring or extra-curricular activities. Organisational and local culture can be a facilitator in this abuse and allow it to continue even when concerns are raised. Practical prevention measures are suggested to assist in reducing future abuse. [ABSTRACT FROM AUTHOR]

Climate change, changing farming practices, social and demographic changes and rising levels of antibiotic resistance are likely to lead to future increases in opportunistic bacterial infections that are more difficult to treat. Uncovering the prevalence and identity of pathogenic bacteria in the environment is key to assessing transmission risks. We describe the first use of the Wax moth larva Galleria mellonella, a well-established model for the mammalian innate immune system, to selectively enrich and characterize pathogens from coastal environments in the South West of the UK. Whole-genome sequencing of highly virulent isolates revealed amongst others a Proteus mirabilis strain carrying the Salmonella SGI1 genomic island not reported from the UK before and the recently described species Vibrio injenensis hitherto only reported from human patients in Korea. Our novel method has the power to detect bacterial pathogens in the environment that potentially pose a serious risk to public health. [ABSTRACT FROM AUTHOR]

To date, there has been very little research into the phenomenon of female-perpetrated institutional child sexual abuse (CSA). This study explored 71 cases of CSA perpetrated by women working with children, considered by UK police and courts between 2000 and 2016. Qualitative and quantitative content analysis was employed to examine court reports, professional regulatory body decisions, media reports and an online sentencing database in order to identify perpetrator and victim characteristics, the nature of the offending behaviour, modus operandi and criminal justice system responses. Findings indicate most women offended alone and had no previous criminal or employment records of concern. Victims were typically male and 15-16 years old. Most women received custodial sentences, typically of 2-3 years in length. Implications for policy and practice are also discussed. [ABSTRACT FROM AUTHOR]

Trichodesmium, a colonial cyanobacterium typically associated with tropical waters, was observed between January and April 2014 in the western English Channel. Sequencing of the heterocyst differentiation (hetR) and 16S rRNA genes placed this community within the Clade IV Trichodesmium, an understudied clade previously found only in low numbers in warmer waters. Nitrogen fixation was not detected although measurable rates of nitrate uptake and carbon fixation were observed. Trichodesmium RuBisCO transcript abundance relative to gene abundance suggests the potential for viable and potentially active Trichodesmium carbon fixation. Observations of Trichodesmium when coupled with a numerical advection model indicate that Trichodesmium communities can remain viable for >3.5 months at temperatures lower than previously expected. The results suggest that Clade IV Trichodesmium occupies a different niche to other Trichodesmium species, and is a cold- or low-light-adapted variant. [ABSTRACT FROM AUTHOR]

Questionnaire data captured in January–March 2007 were examined in relation to turnover in males and females during the next five years. In general, most of the workplace stressors (such as role conflict or peer support) were not antecedents of turnover in any group. Junior personnel with psychological strain in 2007 had an increased risk of turnover in the next five years. Low commitment to the service in 2007 increased the odds of turnover in male and female juniors and in female officers. Female juniors with less effective skills for coping with stress and who exercised less frequently on a weekly basis were more likely to leave. An incidental finding was that the odds of turnover were three times greater in female officers with children than in female officers with no children. Stress management interventions focusing on effective coping and sports and exercise participation which are targeted appropriately may improve retention. Practitioner Summary:Much is known about the adverse effects of occupational stress on health and well-being. This study demonstrates a link between stress and employee turnover implying that stress management interventions may benefit employers, by reducing turnover. [ABSTRACT FROM AUTHOR]

Findings from nitrogen (N) manipulation studies have provided strong evidence of the detrimental impacts of elevated N deposition on the structure and functioning of heathland ecosystems. Few studies, however, have sought to establish whether experimentally observed responses are also apparent under natural, field conditions. This paper presents the findings of a nationwide field-scale evaluation of British heathlands, across broad geographical, climatic and pollution gradients. Fifty two heathlands were selected across an N deposition gradient of 5.9 to 32.4 kg ha−1 yr−1. The diversity and abundance of higher and lower plants and a suite of biogeochemical measures were evaluated in relation to climate and N deposition indices. Plant species richness declined with increasing temperature and N deposition, and the abundance of nitrophilous species increased with increasing N. Relationships were broadly similar between upland and lowland sites, with the biggest reductions in species number associated with increasing N inputs at the low end of the deposition range. Both oxidised and reduced forms of N were associated with species declines, although reduced N appears to be a stronger driver of species loss at the functional group level. Plant and soil biochemical indices were related to temperature, rainfall and N deposition. Litter C:N ratios and enzyme (phenol-oxidase and phosphomonoesterase) activities had the strongest relationships with site N inputs and appear to represent reliable field indicators of N deposition. This study provides strong, field-scale evidence of links between N deposition - in both oxidised and reduced forms - and widespread changes in the composition, diversity and functioning of British heathlands. The similarity of relationships between upland and lowland environments, across broad spatial and climatic gradients, highlights the ubiquity of relationships with N, and suggests that N deposition is contributing to biodiversity loss and changes in ecosystem functioning across European heathlands. [ABSTRACT FROM AUTHOR]

Ecosystems are subject to multiple, natural and anthropogenic environmental influences, including nitrogen ( N) deposition, land use and climate. Assessment of the relative importance of these influences on biodiversity and ecosystem functioning is crucial for guiding policy and management decisions to mitigate global change; yet, few studies consider multiple drivers. In the UK, ongoing loss of the internationally important arctic/alpine moss-sedge community, Racomitrium heath, has been linked to elevated N deposition, high grazing pressures and their combination; however, the relative importance of these drivers remains unclear. We used environmental gradients across the habitat's European distribution ( UK, Faroes, Norway and Iceland) to investigate the relative impact of N deposition and grazing pressure, as well as climate, on the condition of the dominant moss species, Racomitrium lanuginosum. Key variables including tissue chemistry, growth and cover were measured at 36 sites, and multiple linear regressions were used to examine the relative importance of the drivers across sites. Our results clearly show that regional variation in the condition of R. lanuginosum across Europe is primarily associated with the impacts of N deposition, with climate (air temperature) and grazing pressure playing secondary roles. In contrast to previous experimental studies, we found moss growth to be stimulated by elevated N deposition; this apparent discrepancy may result from the use of artificially high N concentrations in many experiments. Despite increased growth rates, we found that moss mat depth and cover declined in response to N deposition. Our results suggest that this is due to increased decomposition of material in the moss mat, which ultimately leads to loss of moss cover and habitat degradation. This study clearly demonstrates both the key role of N deposition in degradation of Racomitrium heath and the importance of observational studies along natural gradients for testing predictions from experimental studies in the real world. [ABSTRACT FROM AUTHOR]

There is a growing need to standardize and validate outcomes for asthma research. In this review of asthma-related publications from the Journal in 2009, efforts to standardize methodology and reporting of translational research, the influence of the environment, therapeutics, and management of asthma are highlighted. [Copyright &y& Elsevier]

Purpose -- The purpose of this paper is to determine those factors perceived by users to influence the successful on-going use of e-commerce systems in business-to-business (B2B) buying and selling transactions through examination of the views of individuals acting in both purchasing and selling roles within the UK National Health Service (NHS) pharmaceutical supply chain. Design/methodology/approach -- Literature from the fields of operations and supply chain management (SCM) and information systems (IS) is used to determine candidate factors that might influence the success of the use of e-commerce. A questionnaire based on these is used for primary data collection in the UK NHS pharmaceutical supply chain. Factor analysis is used to analyse the data. Findings -- The paper yields five composite factors that are perceived by users to influence successful e-commerce use. "System quality," "information quality," "management and use," "world wide web -- assurance and empathy," and "trust" are proposed as potential critical success factors. Of these, all respondents ranked information quality, system quality, and trust as being of most importance, but differences in the rankings between purchasing and selling respondents are evident. Research limitations/implications -- The empirical study is limited to a single supply network, and although the findings seem intuitively to be of relevance to other sectors and supply contexts, there remains an opportunity to test this through further research. There is also an opportunity to extend the survey research, particularly into the wholesaler organisations that operate in the sector of study. Practical implications -- The managerial implications that result from this research provide practical guidance to organisations in this sector on how to ensure that e-commerce systems for B2B buying and selling are used successfully. Originality/value -- This paper furthers knowledge and understanding in the fields of operations management, IS, and SCM, by suggesting potential determinants of successful e-commerce use in both buying and selling organisations within supply networks. [ABSTRACT FROM AUTHOR]

Policy makers are faced with the task of ensuring that parents are offered information on children's Web sites to help them reduce their children's online privacy risks. This exploratory research compares the approaches of two countries with different regulatory philosophies regarding children's privacy: the United States, with a limited and sectoral approach to general privacy but a formalized approach to children's online privacy, and the United Kingdom, with a comprehensive overarching approach to privacy, but no formal stipulations for children's privacy. We examined privacy statements on 100 children's Web sites from each country in order to compare the products of each regulatory environment. [ABSTRACT FROM AUTHOR]

Participation at the local level is an important factor in determining the success of programmes developed to achieve sustainable development. This paper is concerned with debates over the role of the individual citizen in relation to that participatory process. In particular, it focuses on the UK Governments’ citizens environmental initiative ‘Going for Green’ (GFG). Through this initiative a five-point Green Code was developed to assist in the delivery of its sustainable development message to the general public. The initiative's overall approach to participation was based on an assumption that the primary barrier to translating environmental concern into local action was a lack of information, and that individuals would respond to messages in a similar way. As a research strategy, the case study was used to evaluate how the initiatives’ pilot Sustainable Communities Project was implemented in two comparative geographical communities in Merthyr Tydfil (South Wales). Research findings from this study have demonstrated that the case study was invaluable in terms of understanding the participatory process and experiences of broad a range of community stakeholders. Promoting a single model of participation, GFG was found to restrict the participatory process in terms of who was encouraged to participate, the scope of their participation, and those outcomes that could be achieved. This paper concludes that if significant progress is to be made in relation to achieving sustainable development, the role of the individual citizen needs to be extended beyond that of a consumer of the environment, and involve active participation in a process that is based on collective action. [ABSTRACT FROM AUTHOR]

Deposition of reactive nitrogen (N) is a major threat to terrestrial ecosystems associated with impacts on ecosystem properties and functions including carbon (C) and nutrient stocks, soil water quality and nutrient retention. In the oceanic-alpine Racomitrium heath habitat, N deposition is associated with moss mat degradation and a shift from bryophyte to graminoid dominance. To investigate the effects of moss mat decline on C and N stocks and fluxes, we collected Racomitrium heath vegetation/soil cores from sites along a gradient of N deposition in the UK. Cores were maintained under controlled conditions and exposed to scenarios of current (8–40 kg N ha−1 y−1), reduced (8 kg N ha−1 y−1) and elevated (50 kg N ha−1 y−1) N deposition. Cores from high N deposition sites had smaller aboveground C and N stocks and, under current conditions, leached large amounts of inorganic N and had low soil water pH compared with low N deposition sites. With reduced N deposition there was evidence for rapid recovery of soil water quality in terms of reduced N leaching and small increases in pH. Under high N deposition, cores from low N deposition sites retained much of the applied N while those with a history of high N deposition leached large amounts of inorganic N. Carbon fluxes in soil water and net CO 2 fluxes varied according to core source site but were not affected by the N deposition scenarios. We conclude that C and N stocks and cycling in Racomitrium heath are strongly affected by long-term exposure to N deposition but that soil water quality may improve rapidly, if N deposition rates are reduced. The legacy of N deposition impacts on moss mat cover and vegetation composition however, mean that the ecosystem remains sensitive to future pulses in N input. Image 1 • We examined impacts of N deposition on C and N cycling in alpine moss heath. • High N deposition reduces above ground C and N stocks. • Sites receiving high N deposition leach large amounts of inorganic N in soil water. • Under reduced N deposition soil water quality rapidly improves. • Past exposure to high N deposition reduces ecosystem ability to retain deposited N. Nitrogen deposition on alpine Racomitrium heath negatively impacts C and N stocks and soil water quality but rapid improvements can be made if N deposition declines. [ABSTRACT FROM AUTHOR]

Abstract: Background: We sought to determine the risk of an allergic reaction to a cephalosporin exposure in those with prior penicillin reactions. Methods: We conducted a retrospective cohort study using the United Kingdom General Practice Research Database. We selected all patients receiving a prescription for penicillin followed by a prescription for a cephalosporin and identified allergic-like events within 30 days after each prescription. Allergic events were defined by 2 sets of codes: 1 more restrictive, 1 more inclusive. Comparison was made with a population of patients receiving a prescription for a penicillin followed by a prescription for a sulfonamide antibiotic. Results: A total of 3 375 162 patients received a penicillin; 506 679 (15%) received a subsequent cephalosporin. Among patients receiving a penicillin followed by a cephalosporin, the unadjusted risk ratio of an allergic-like event for those who had a prior event, compared with those who had no such prior event, narrowly defined, was 10.1 (confidence interval 7.4-13.8). The absolute risk of anaphylaxis after a cephalosporin was less than 0.001%. The unadjusted risk ratio for sulfonamide antibiotic, rather than cephalosporin after penicillin allergic-like events was 7.2 (confidence interval 3.8-13.5). Conclusion: Patients with allergic-like events after penicillin had a markedly increased risk of events after either subsequent cephalosporins or sulfonamide antibiotics. Cross-reactivity is not an adequate explanation for this increased risk, and the risk of anaphylaxis is very low. Thus, our data indicate that cephalosporins can be considered for patients with penicillin allergy. [Copyright &y& Elsevier]

Covers medicine-related news briefs in the United Kingdom as of February 6, 1999. Information on birdshot retinochoroidopathy; Difference of elite athletes from ordinary people; Risk factors for the outbreak of Legionnaire's disease; Confirmation on the effectiveness of superovulation combined with artificial insemination as a treatment for infertility.

Empirical critical loads are widely used to quantify and manage the ecological impacts of reactive nitrogen (N) deposition. Critical load values aim to identify a level of N deposition below which significant harmful effects do not occur according to present knowledge. Critical loads have been primarily based on experiments, but these are few in number and have well-known limitations, so there is a strong imperative to test and validate values with other forms of evidence. We assembled data on the spatial variability in vegetation communities in the United Kingdom and used Threshold Indicator Taxa Analyses (TITAN) to investigate linkages between species changes and modelled current and cumulative N deposition. Our analyses focused on five datasets: acid grasslands, alpine habitats, coastal fixed dunes, dune slacks and wet grasslands. In four of these habitats there was evidence for a significant decline in the cover of at least one species (a 'species-loss change-point') occurring below the critical load, and often at very low levels of N deposition. In all of the habitats there was evidence for clustering of many individual species-loss change-points, implying a community change-point analogous to an ecological threshold. Three of these community change-points occurred below the critical load and the remaining two overlapped with the critical load range. Studies using similar approaches are now increasingly common, with similar results. Across 19 similar analyses there has been evidence for plant species loss change-points below the critical load in 18 analyses, and community-level species loss change-points below the critical load in 13 analyses. None of these analyses has shown community change-points above the critical load. Field data increasingly suggest that many European critical loads are too high to confidently prevent loss of sensitive species. • We analysed plant cover changes along N deposition gradients for five UK habitats. • Our study shows both species and community changes below the current critical load. • Current critical loads may be too high to prevent biodiversity impacts. [ABSTRACT FROM AUTHOR]

Objective: Whether and how dietary protein intake is linked to type 2 diabetes (T2D) remains unclear. The aim of this study was to investigate the associations of protein intake with development of T2D and the potential mediating roles of T2D biomarkers., Research Design and Methods: We included 108,681 postmenopausal women without T2D at baseline from the Women's Health Initiative (WHI) (primary cohort) and 34,616 adults without T2D from the U.K. Biobank (UKB) (replication cohort). Cox proportional hazard models were used for estimation of protein-T2D associations. Mediation analysis was performed to assess the mediating roles of biomarkers in case-control studies nested in the WHI., Results: In the WHI, 15,842 incident T2D cases were identified during a median follow-up of 15.8 years. Intake of animal protein was associated with increased T2D risk (hazard ratio in comparing the highest to the lowest quintile = 1.31 [95% CI 1.24-1.37]) and plant protein with decreased risk (0.82 [0.78-0.86]). Intakes of red meat, processed meat, poultry, and eggs were associated with increased T2D risk and whole grains with decreased risk. Findings from the UKB were similar. These findings were materially attenuated after additional adjustment for BMI. Substituting 5% energy from plant protein for animal protein was associated with 21% decreased T2D risk (0.79 [0.74-0.84]), which was mediated by levels of hs-CRP, interleukin-6, leptin, and SHBG., Conclusions: Findings from these two large prospective cohorts support the notion that substituting plant protein for animal protein may decrease T2D risk mainly by reducing obesity-related inflammation., (© 2022 by the American Diabetes Association.)

Immune checkpoint inhibitors (ICIs) have revolutionised oncology and are now standard-of-care for the treatment of a wide variety of solid neoplasms. However, tumour responses remain unpredictable, experienced by only a minority of ICI recipients across malignancy types. Therefore, there is an urgent need for better predictive biomarkers to identify a priori the patients most likely to benefit from these therapies. Despite considerable efforts, only three such biomarkers are FDA-approved for clinical use, and all rely on the availability of tumour tissue for immunohistochemical staining or genomic assays. There is emerging evidence that host factors - for example, genetic, metabolic, and immune factors, as well as the composition of one's gut microbiota - influence the response of a patient's cancer to ICIs. Tantalisingly, some of these factors are modifiable, paving the way for co-therapies that may enhance the therapeutic index of these treatments. Herein, we review key host factors that are of potential biomarker value for response to ICI therapy, with a particular focus on the proposed mechanisms for these influences. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland., (© 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.)

In alpine ecosystems, nitrogen (N) deposition has been linked to plant community composition change, including loss of bryophytes and increase of graminoids. Since bryophyte growth is stimulated by increased N availability, it has been hypothesized that loss of bryophyte cover is driven by enhanced decomposition. As bryophyte mats are a significant carbon (C) store, their loss may impact C storage in these ecosystems. We used an N deposition gradient across 15 sites in the UK to examine effects of N deposition on bryophyte litter quality, decomposition and C and N stocks in Racomitrium moss-sedge heath. Increasing N deposition reduced C : N in bryophyte litter, which in turn enhanced decomposition. Soil N stocks increased significantly in response to increased N deposition, and soil C : N declined. However, depletion of the bryophyte mat and its replacement by graminoids under high N deposition was not associated with a change in total ecosystem C stocks. We conclude that decomposition processes in Racomitrium heath are very sensitive to N deposition and provide a mechanism by which N deposition drives depletion of the bryophyte mat. Nitrogen deposition did not measurably alter C stocks, but changes in soil N stocks and C : N suggest the ecosystem is becoming N saturated., (© 2018 The Authors. New Phytologist © 2018 New Phytologist Trust.)