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Objective: Around 40% of US university students use cannabis, 25% of whom present with cannabis use disorder, which endangers health. We investigated the concurrent contribution of reflective processes, which generate action via conscious deliberation, and non-reflective processes, which prompt behavior automatically, to undergraduates' cannabis consumption. Participants: Eighteen UK undergraduates who regularly consume cannabis (11 female, 7 male; mean age 20 y). Methods: Semi-structured interviews explored cannabis motives, routines, cues, and decision points. Thematic analysis identified themes, in each of which reflective and non-reflective dimensions were coded. Results: Four themes were identified: cannabis use for relaxation, social bonding, and symbolic-affective significance, and contexts and triggers. Some influences guided cannabis use reflectively in some settings, and non-reflectively in others. Even when cannabis use was consciously driven, non-reflective processes were deployed to execute subservient acts, such as rolling joints. Conclusions: Findings highlight specific processes and pathways that might be targeted to reduce cannabis-related harm.

COVID-19 forced the closure of UK universities. One effect of this was a change in how lectures, and their recordings, were made and used. In this research, we aimed to address two related research questions. Firstly, we aimed to understand how UK universities replaced in-person lectures and, secondly, to establish what academic staff believed the post-pandemic lecture would look like. In a mixed-methods study, we collected anonymous quantitative and qualitative data from 87 academics at 36 UK institutions. Analysis revealed that respondents recognised the value and importance of interactive teaching and indicated that the post-pandemic lecture would and should make greater use of this. Data also revealed positive views of lecture capture, in contrast to pre-pandemic studies, and demonstrated that staff recognised their value for those who were unable to attend, or who had specific learning differences. However, staff also recognised the value of asynchronous lecture videos within a blended or flipped approach. This study provides evidence that the pandemic has engendered changes in attitudes and practices within UK higher education that are conducive to educational reform.

Teacher education has gathered interest globally and nationally among teachers, educators, researchers and policy makers. Madalinska-Michalak, O 'Doherty and Assuno Flores (2018) observe that regional/ national, social, economic, political and historical factors impact upon teacher education and 'it is also impacted by global problems and tendencies' (pp. 567). This paper builds on these debates and examines the effects of global discourses of teacher education in the national contexts of developed and developing countries, for example, Guyana, Japan, South Africa, United States of America (USA) and the United Kingdom (UK). This includes consideration of teacher education and training before and during the current global COVID-19 pandemic (UNESCO, 2020). The paper concludes that teacher education continues to be under scrutiny due to global and national expectations, the demand of and how they are positioned in preparing teachers for the 21st century. Notwithstanding, as globalisation becomes more integrated in societies globally teacher education curricula not only has to retain its emphasis on standards, but equally its agility to ensure that the needs of all learners are met.

One of the fundamental ways in which knowledge develops is through contrast. This applies not only to the development of ideas and theories in argumentative texts, but also to the contrasting of new findings with old in experimental reports. Contrast, then, is central to the development of academic knowledge. A common finding in contrastive analyses is that the transition "however" is used significantly more by English than Chinese writers. This has been explained through suggestions that Chinese writers may be culturally less willing or linguistically less able to express contrast. Our objective was to identify which transitions of contrast are used more by Chinese students and to understand where and how they are used. In the closely matched Han CH-EN corpus of similar texts written by successful Chinese and English students at British universities, we identified four transitions that are used significantly more (p < 0.05) by Chinese writers: "while," "whereas," "on the other hand," and "in contrast." Through examining contexts of use and specific examples, we argue that Chinese students employ a greater variety of transitions than English students to achieve a similar amount of contrast in their writing. The paper concludes with seven implications for teaching academic writing in English.

Aim: To assess the knowledge, attitudes and practices of Registered Nurses working in residential aged care facilities pertaining to pain management for residents living with dementia. Background: Sub-optimal pain management continues for people living with dementia in residential aged care. Registered Nurses are the pivotal staff responsible for complex assessment and management of people residing in residential aged care facilities. Design and methods: :This integrative literature review was informed by Whittemore (2005). Searching and screening followed the PRISMA guidelines. Results: Thirteen papers were identified, the major themes identified were gaps in knowledge and skills, uncertainty of assessment, and delays in treatment. Conclusion: Registered Nurses require education on pain management for people living with dementia in residential aged care. Broader issues in residential aged care contribute to the problem and require examination. Research pertaining to Registered Nurses' roles pain management for residents living with dementia is required. [ABSTRACT FROM AUTHOR]

Introduction: The novel Confirm Rx™ implantable cardiac monitor (ICM) with SharpSense™ technology incorporates a new P‐wave discriminator designed to improve AF detection. This study aimed to evaluate the diagnostic performance of the Confirm Rx™ ICM in detecting AF episodes of varying durations. Methods: We conducted a multicenter retrospective analysis of consecutive patients implanted with a Confirm Rx™ ICM (v1.2) across nine UK hospitals, all with documented AF lasting at least 6 min. Electrocardiograms (ECGs) were manually adjudicated by cardiologists. To account for intra‐ and inter‐reviewer variability, a random sample of 10% of ECGs underwent additional review. Disagreements were resolved by a third reviewer. Diagnostic performance was determined by calculating the gross and patient‐averaged positive predictive value (PPV) for AF episodes of different duration. The source of false positive (FP) detection was also categorized. Results: Overall, 16,230 individual ECGs from 232 patients were included. The median AF episode duration was 14 min. R‐wave amplitude remained stable during follow‐up (0.52 ± 0.27 mV [initial] vs. 0.54 ± 0.29 mV [end of follow‐up], p =.10). The gross and patient‐averaged PPV were 75.0% and 67.0%, respectively. Diagnostic performance (gross) increased with progressively longer AF episodes: 88.0% for ≥1 h, 97.3% for 6 h, and 100% for 24 h. The main source of FP during tachycardia was T‐wave oversensing (54.2%), while in non‐tachycardic episodes it was predominantly ectopy (71.2%). The AF burden precision was excellent (93.3%). Conclusion: The Confirm Rx™ ICM diagnostic performance was modest for all AF episodes (75%), with accuracy increasing for longer AF episodes. [ABSTRACT FROM AUTHOR]

Societal Impact Statement: Increasing crop productivity is often proposed as a key goal for meeting the food security demands of a growing global population. However, achieving high crop yields alone without meeting end‐use quality requirements is counter to this objective and can lead to negative environmental and sustainability issues. High yielding feed wheat crops in the United Kingdom are a typical example of this. The historical context of UK agricultural industrialisation, developments in plant breeding and wheat end‐use processing are examined. We then outline how employing innovations in plant breeding methods offer the potential to redress the balance between wheat quantity and quality. Summary: Bread wheat (Triticum aestivum L.) has historically been an important crop for many human civilisations. Today, variability in wheat supply and trade has a large influence on global economies and food security. The United Kingdom is an example of an industrialised country that achieves high wheat yields through intensive cropping systems and a favourable climate. However, only a minority of the wheat grain produced is of suitable end‐use quality for modern bread baking methods and most wheat produced is fed to livestock. A large agricultural land area and input use dedicated to producing grain for animal rather than human food has wide‐ranging negative impacts for environmental sustainability and domestic food production. Here we present an historical perspective of agricultural and economic changes that have resulted in UK production primarily focussing on wheat quantity over quality. Agricultural intensification, liberalisation of free trade in agricultural commodities, innovations in the milling and baking sector, developments in scientific understanding of genetics and plant breeding, and geopolitical changes have all played a role. We propose that wheat breeding plays a crucial role in influencing these issues and although wheat breeders in the United Kingdom have historically applied the most‐up‐to‐date scientific advances, recent advances in genomics tools and quantitative genetics present a unique opportunity for breeders to redress the balance between quantity and quality. [ABSTRACT FROM AUTHOR]

Formative assessment is widely accepted as being crucial to promoting student learning and, since 2010, the UK General Medical Council has mandated its use in workplace-based clinical training for all new doctors. As a result, the Royal College of Radiologists (RCR) instituted a range of formative workplace-based assessments including the Radiology Direct Observation of Procedural Skills (Rad-DOPS), in which supervisors appraise trainees' performance in carrying out clinical procedures. This paper reports on the quality of the written feedback in 2,500 Rad-DOPS online feedback forms in addressing the aims of the new assessment approach. Random samples of 500 were selected from the first three years of the new assessment implementation, 2010-13, and from 2016 to 17. Using an appropriate coding frame, the feedback was analysed across the samples against key trainee attributes including stage of training and level of adjudged competence. Criteria for identifying high quality feedback were derived from the literature and a simplified form of qualitative comparative analysis was used to identify the conditions associated with high quality feedback. An average of 97% of the assessments contained written feedback but the number of instances of high quality feedback was found to be exceedingly small at around 5%. The paper offers suggestions for making the feedback process more purposeful in achieving the aims of formative assessment.

Background: Oral language skills provide the foundation for formal education, yet many children enter school with language weaknesses. This study evaluated the efficacy of a new language enrichment programme, the Nuffield Early Language Intervention—Preschool (NELI Preschool), delivered to children in the year before they enter formal education. Methods: We conducted a preregistered cluster randomised controlled trial in 65 nursery schools in England (https://doi.org/10.1186/ISRCTN29838552). NELI Preschool consists of a 20‐week whole‐class language enrichment programme delivered by a teacher each day for 20 min. In addition, children with the weakest language skills in each class are allocated to receive additional targeted support delivered by classroom assistants (whole‐class + targeted). The language skills of all children (n = 1,586) in participating classrooms were assessed using the LanguageScreen automated app (https://oxedandassessment.com/languagescreen/). Settings were then randomly allocated to an intervention or control group. The children with the weakest language in each class (whole‐class + targeted children n = 438), along with four randomly selected children in each class allocated to the whole‐class only programme (n = 288) were individually tested on a range of language measures. Results: Children receiving NELI Preschool made larger gains than children in the control group on an oral language latent variable (whole‐class children d =.26; whole‐class + targeted children d =.16). Conclusions: This study provides good evidence that whole‐class intervention delivered in preschool can produce educationally significant improvements in children's language skills. The intervention is scaleable and relatively low cost. These findings have important implications for educational and social policy. [ABSTRACT FROM AUTHOR]

For the 'global middle classes', cultural reproduction increasingly involves the international school as they promise considerable distinction [Bourdieu, P. 1984. "Distinction: A Social Critique of the Judgement of Taste." Cambridge, MA: Harvard University Press] granting University passage past Anglo gate-keepers. This paper draws on research providing a multiphase exploration of the character of senior leadership in IB international schools. Participants emerged as white 'English' and Christian. However, data collected show that these leaders do not operationalise (organisational) international values; instead, they draw upon their own societal values in leadership. Yet, their stories and outlooks of global-mindedness sit uncritically, framed in 'Inner Circle English' [Kachru, B. 1985. "Standards, Codification and Sociolinguistic Realism: The English Language in the Outer Circle." In "English in the World: Teaching and Learning the Language and Literatures", edited by R. Quirk and H. G. Widdowson, 11-34. Cambridge: Cambridge University Press] advantage. Participants lean on a power-narrative of middle-class 'Englishness'. As powerful policy-makers, this orientation defines the international school's mission and vision. It appeals to the surge of international education, particularly in the global South, where international schools can be seen as incubators of 'English' epistemic advantage. It is unlikely that the consolidation of the 'Brand of Britain' will affect this demographic and their choices to 'go UK'. The affordance of diminishing EU participation in the UK higher education system may work in favour of globalising middle classes and elites. Conversely, it is unlikely that lower income EU or UK domestic HE participation is likely to profit from this move.

This paper draws on findings of comparative international research on students' poetic writing about the natural environment in the context of the classroom and a naturalistic setting. The study involved 97, nine- to 10-year-olds in four classes: two classes were in an English primary school with their counterparts in a Western Australian primary school. One class in each school had vicarious contact with nature as a stimulus for writing, using a previously taught technique for writing poetry; the other class in each school used the same technique but had direct contact with nature. The study has implications for students' literacy development, creativity and agency and suggests that students' poetic writing is enhanced through direct contact with nature. Teachers in both England and Australia, countries where 'high stakes' testing dominates the literacy curriculum, may find that standards of writing improve when students are given direct contact with natural spaces and are scaffolded to elicit their poetic voice.

An implantable left ventricular assist device (LVAD) is indicated as a bridge to transplantation or recovery in the United Kingdom (UK). The mechanism of action of the LVAD results in a unique state of haemodynamic stability with diminished arterial pulsatility. The clinical assessment of an LVAD recipient can be challenging because non-invasive blood pressure, pulse and oxygen saturation measurements may be hard to obtain. As a result of this unusual situation and complex interplay between the device and the native circulation, resuscitation of LVAD recipients requires bespoke guidelines. Through collaboration with key UK stakeholders, we assessed the current evidence base and developed guidelines for the recognition of clinical deterioration, inadequate circulation and time-critical interventions. Such guidelines, intended for use in transplant centres, are designed to be deployed by those providing immediate care of LVAD patients under conditions of precipitous clinical deterioration. In summary, the Joint British Societies and Transplant Centres LVAD Working Group present the UK guideline on management of emergencies in implantable LVAD recipients for use in advanced heart failure centres. These recommendations have been made with a UK resuscitation focus but are widely applicable to professionals regularly managing patients with implantable LVADs. [ABSTRACT FROM AUTHOR]

The 28-days-to-diagnosis pathway is the current expected standard of care for women with symptoms of ovarian cancer in the UK. However, the anticipated conversion rate of symptoms to cancer is only 3%, and use of the pathway is increasing. A rapid triage at the moment of receipt of the referral might allow resources to be allocated more appropriately. In secondary care, multidisciplinary teams (MDTs) use the risk of malignancy index (RMI) score, (multiply menopausal status pre = 1 or post = 3 × ultrasound score = 0 − 3 × the CA 125 level), using a score of >200, to triage urgency and management in possible ovarian cancer cases. The most powerful determinant of the RMI score variables is CA 125 level, an objective number. Could a simple modification of the RMI score retain a high sensitivity for cancer whilst improving specificity and, consequently, decrease the morbidity of false-positive classification? To test this hypothesis, a retrospective evaluation of an ovarian two-week-wait telephone clinic of one consultant gynaecological oncologist was undertaken. Enquiry re menopause status was scored as one for pre- and three for postmenopausal or uncertain. CA 125 levels of >67 u/mL for premenopausal and >23 u/mL for postmenopausal women were used to precipitate urgent cross-sectional imaging requests and MDT opinions. These CA 125 cut thresholds were calculated using an assumption that the RMI imaging score, regardless of whether the result was available, could be three. We contemplate that women who did not exceed a provisional RMI score of >200 might be informed they are extremely unlikely to have cancer, removed from the malignancy tracker and appropriate follow-up arranged. One hundred and forty consecutive cases were analysed; 43% were deemed premenopausal and 57% postmenopausal. Twenty of the women had cancer, eighteen (90%) of whom had an RMI > 200. One hundred and twenty were benign, and only twenty-three (19%) classified as urgent cases in need of accelerated referral to imaging. In contrast, CA 125 > 35 u/mL, whilst retaining the sensitivity of 90%, misclassified 36 (30%) of the benign cases. It is possible that a telephone triage via a questionnaire determining menopausal status and the CA 125 result could offer a sensitivity for cancer of 90% and urgent expert review of under 20% of benign cases. This rapid initial telephone assessment could be presented by a trained pathway navigator, physician associate or nurse specialist. Substantial savings in NHS cancer services resources, anxieties all around and reduced patient morbidity may occur as a result. [ABSTRACT FROM AUTHOR]

Background: Prisoners with intellectual disabilities are known to be disadvantaged in prisons and to be more susceptible to bullying, segregation, depression and anxiety than other prisoners. Method: In this study, nearly 3000 new prisoners entering three English prisons were offered screening for intellectual disabilities, using the LDSQ. Results: On average, 75% of all new prisoners entering prison were offered screening, and only 14% refused screening. Overall, just less than 7% were screened positive on the LDSQ and prisons made some reasonable adjustments as a result. Conclusions: It is argued that it is feasible to screen for intellectual disabilities in prisons and, given the inequalities to which prisoners with intellectual disabilities are subject in prison, it is time for such screening to be rolled out to all prisons.

Background: Limited knowledge exists on current use of patient reported outcome measures (PROMs) and performance measures for adolescents with idiopathic scoliosis (AIS), as well as health care professionals' (HCPs) perceived barriers and facilitators towards their use. This study's objectives were: 1) to explore current practice of HCPs when assessing outcomes for AIS 2) to understand perceived barriers and facilitators of HCPs to use PROMs 3) to understand perceived barriers and facilitators of HCPs to use performance measures. Methods: A qualitative study recruited a purposive sample of HCPs from a tertiary hospital in the United Kingdom. Mean years of experience managing individuals with AIS was 11.8 years; and included surgeons, physiotherapists and nurses, educated at Bachelor, Masters and Doctoral level. Consent to participate and demographic information were collected in advance of the interviews. In-depth, virtual semi-structured interviews were informed by a topic guide based on current evidence. Interviews of approximately 45 minutes were audio and video recorded and transcribed verbatim alongside written field notes. Data were coded and analysed using inductive thematic analysis, involving researchers with topic and methodological expertise and input from a patient representative. Results: Two themes emerged regarding current practice of using PROMs routine practice and personal evaluations. Four themes emerged as barriers to using PROMs for individuals with AIS: priority and support (e.g., HCPs focus on providing care), practical challenges (e.g., inadequate PROMs), patient-related challenges (e.g., patient preferences) and knowledge, education, and perceived value. Two themes emerged as facilitators: quality existing measure (e.g., sufficient psychometric properties), and priority and support (e.g., research department/culture). Themes for barriers to use performance measures were practicality (e.g., need physical space) and perceived value and knowledge (e.g., PROMs are more important), while the one theme for facilitators was practical consideration (e.g., acceptability). Conclusions: Although HCPs perceived the value of using outcome measures, current practice indicates limited use for individuals with AIS. The findings revealed different barriers and facilitators to implement PROMs in practice. Adopting performance measure are limited due to lack of knowledge and perceived value alongside the practicality, while considering practical factors can improve the use of these measures in practice. [ABSTRACT FROM AUTHOR]

Around 40% of US university students use cannabis, 25% of whom present with cannabis use disorder, which endangers health. We investigated the concurrent contribution of reflective processes, which generate action via conscious deliberation, and non-reflective processes, which prompt behavior automatically, to undergraduates' cannabis consumption. Eighteen UK undergraduates who regularly consume cannabis (11 female, 7 male; mean age 20 y). Semi-structured interviews explored cannabis motives, routines, cues, and decision points. Thematic analysis identified themes, in each of which reflective and non-reflective dimensions were coded. Four themes were identified: cannabis use for relaxation, social bonding, and symbolic-affective significance, and contexts and triggers. Some influences guided cannabis use reflectively in some settings, and non-reflectively in others. Even when cannabis use was consciously driven, non-reflective processes were deployed to execute subservient acts, such as rolling joints. Findings highlight specific processes and pathways that might be targeted to reduce cannabis-related harm. [ABSTRACT FROM AUTHOR]

Attempts to improve evening sleep hygiene have overlooked that sleep preparation behaviours are often undertaken automatically with little awareness; that is, habitually. This mixed-methods study assessed aspects of the feasibility and acceptability of a novel behavioural intervention procedure ('script elicitation'), which encourages reflection on and reorganisation of the content and sequencing of habitual evening pre-sleep routines. The study was advertised via social media, and circular lists at a UK university. Twenty-four UK-based adults, reporting <6 h/night sleep, were recruited. At baseline, they completed sleep hygiene and quality measures, then participated in an online, one-to-one script elicitation interview. This involved the interviewer working with the participant to generate a fine-grained description of the content, organisation and variability of their typical pre-sleep routine, and plan a more sleep-conducive alternative routine to follow over the next week. One week later, participants completed sleep quality and hygiene measures, and a semi-structured interview about the intervention. Feasibility was assessed using quantitative data on response rates and attrition, and acceptability via sleep hygiene and quality scores, and qualitative data on intervention experiences. All criteria were met. The target response rate was exceeded, none of the 24 participants dropped out, and sleep hygiene and quality scores either improved or remained stable. In interviews, all participants reported finding script elicitation useful. Script elicitation raised participants' awareness of habitual sleep hygiene routines, which gave many a newfound sense of autonomy over changing their sleep hygiene habits. While the habitual nature of existing routines obstructed change for some participants, most reported successfully changing aspects of their routine, and achieving behaviour, sleep and wellbeing improvements. Script elicitation is a promising and acceptable method for tackling poor evening sleep hygiene habits. A more rigorous trial is warranted. [ABSTRACT FROM AUTHOR]

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Children identified with special educational needs (SEN) and behavioural difficulties present extra challenges to educators and require additional supports in school. This paper presents views from special educational needs coordinators (SENCos) on various strategies used by educators to support children identified with SEN and problematic behaviours. The data were collected from telephone interviews with six SENCos from the UK's South West Peninsula. The SENCos were invited to participate because their school was participating in a cluster-randomised trial of a teacher classroom management course (Incredible Years). Using thematic analysis to analyse the data, this paper illustrates strategies deemed by SENCos to be successful in the support of children identified with SEN. The management strategies generated by participating SENCos were then mapped onto those taught as part of the classroom management course for comparison. Findings indicate that strategies from the training programme appear to be appropriate for children identified with both SEN and behavioural difficulties.

The Good Friday Agreement (1998) between the UK and Irish governments, and most of the political parties in Northern Ireland, heralded a significant step forward in securing peace and stability for this troubled region of the British Isles. From the new-found stability, the previous fits and starts of education reform were replaced by a determination for modernisation and innovation, infused with a new energy and momentum. This sense of purpose embraced a complex weave of ideas and ideals; all designed variously to smooth, celebrate and harness community differences for the collective good. Much progress has been made in the intervening years since 1998, particularly in political structures and relationships. However, the euphoria of the new dawn of the Agreement had barely begun to shape the future before entrenched "tribal" tensions reproduced the same political and legislative impasses of former years and visited their all-too-familiar blight on the economic, cultural and educational landscapes. This paper focuses on two signature dimensions of education that have been sustained by this partisanship: segregation by religion and segregation by academic selection.

Conducting research into young learner experiences of school poses methodological challenges which are compounded when, as is increasingly the case, the classroom interaction is multilingual and the research methods are participatory. Each new or adapted method sheds further light on the issues that can arise. Researcher-initiated role play is a method where a researcher invites a group of children to engage in role play, something that many young children do spontaneously. This gives children the interactional space to take control of the specifics of the role play and to present their perspectives and concerns through multiple semiotic layers. This paper explores ethical issues that arise when role play reveals familiar but occluded practices; practices that are not readily presented to outsiders. Specifically, when this researcher-initiated role play was used to explore how children in their first years of school learn to read in different languages and in different multilingual, primary school contexts, certain occluded disciplinary practices were revealed. This paper considers the nature of an ethical response to such revelations.

Scholars have increased their interest in the body as it relates to social inequality and health. The purpose of this review was to understand social work's engagement with and adoption of embodiment. The authors identified peer-reviewed articles to answer research questions about the number of publications, journals, countries and topic areas. There were 89 articles published over a 20-year period with the highest number in medical journals and the most prolific region, the United Kingdom. Major topic areas included gender, ageing and disability. The authors discuss findings and silences in the data and offer suggestions for the field going forward. [ABSTRACT FROM AUTHOR]

Protected areas (PAs) are a core component in global efforts to prevent further declines in biodiversity. We examine whether the United Kingdom's PA portfolio has reduced local extinctions of breeding birds and consider how the characteristics of different PA designations may have affected conservation outcomes. We use breeding bird atlas data to calculate the proportion of species in each 10 × 10‐km grid cell confirmed as breeding in 1988–1991 but not in 2008–2011. We find that the protection offered by PAs is little to no different from that of the wider landscape and, depending on the type of PA, attribute this to PAs being either too small or not managed for biodiversity outcomes. To meet the ambitious new global targets for expanding PA coverage set at the 15th UN Biodiversity Conference, all countries need to monitor and ensure PA effectiveness; high PA coverage does not guarantee that biodiversity is protected. [ABSTRACT FROM AUTHOR]

Background: Long COVID is a debilitating chronic condition that has affected over 100 million people globally. It is characterized by a diverse array of symptoms, including fatigue, cognitive dysfunction and respiratory problems. Studies have so far largely failed to identify genetic associations, the mechanisms behind the disease, or any common pathophysiology with other conditions such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) that present with similar symptoms. Methods: We used a combinatorial analysis approach to identify combinations of genetic variants significantly associated with the development of long COVID and to examine the biological mechanisms underpinning its various symptoms. We compared two subpopulations of long COVID patients from Sano Genetics' Long COVID GOLD study cohort, focusing on patients with severe or fatigue dominant phenotypes. We evaluated the genetic signatures previously identified in an ME/CFS population against this long COVID population to understand similarities with other fatigue disorders that may be triggered by a prior viral infection. Finally, we also compared the output of this long COVID analysis against known genetic associations in other chronic diseases, including a range of metabolic and neurological disorders, to understand the overlap of pathophysiological mechanisms. Results: Combinatorial analysis identified 73 genes that were highly associated with at least one of the long COVID populations included in this analysis. Of these, 9 genes have prior associations with acute COVID-19, and 14 were differentially expressed in a transcriptomic analysis of long COVID patients. A pathway enrichment analysis revealed that the biological pathways most significantly associated with the 73 long COVID genes were mainly aligned with neurological and cardiometabolic diseases. Expanded genotype analysis suggests that specific SNX9 genotypes are a significant contributor to the risk of or protection against severe long COVID infection, but that the gene-disease relationship is context dependent and mediated by interactions with KLF15 and RYR3. Comparison of the genes uniquely associated with the Severe and Fatigue Dominant long COVID patients revealed significant differences between the pathways enriched in each subgroup. The genes unique to Severe long COVID patients were associated with immune pathways such as myeloid differentiation and macrophage foam cells. Genes unique to the Fatigue Dominant subgroup were enriched in metabolic pathways such as MAPK/JNK signaling. We also identified overlap in the genes associated with Fatigue Dominant long COVID and ME/CFS, including several involved in circadian rhythm regulation and insulin regulation. Overall, 39 SNPs associated in this study with long COVID can be linked to 9 genes identified in a recent combinatorial analysis of ME/CFS patient from UK Biobank. Among the 73 genes associated with long COVID, 42 are potentially tractable for novel drug discovery approaches, with 13 of these already targeted by drugs in clinical development pipelines. From this analysis for example, we identified TLR4 antagonists as repurposing candidates with potential to protect against long term cognitive impairment pathology caused by SARS-CoV-2. We are currently evaluating the repurposing potential of these drug targets for use in treating long COVID and/or ME/CFS. Conclusion: This study demonstrates the power of combinatorial analytics for stratifying heterogeneous populations in complex diseases that do not have simple monogenic etiologies. These results build upon the genetic findings from combinatorial analyses of severe acute COVID-19 patients and an ME/CFS population and we expect that access to additional independent, larger patient datasets will further improve the disease insights and validate potential treatment options in long COVID. [ABSTRACT FROM AUTHOR]

As UK cities and towns become increasingly ethnically and culturally diverse, researchers have tuned into how people inhabit multiculturalism. Ethnographic approaches have focused on the kind of togetherness that people generate as they go about their everyday lives, observing the affective textures of interactions and happenings of the here and now in granular detail. Missing from these accounts is what crowdsourced data might add to understandings of how multicultural places are experienced. What is vital about this kind of data is that it is 'big', involving a diversity of voices similarly intent on messaging their experiences, presenting opportunities to scale up the affect of encounters and to quantify what is difficult to qualify. This paper brings Digital Geographies into conversation with research on everyday multiculturalism to examine qualitatively and quantitatively how social media use folds into and expresses various practices of sociality and connection. Our paper involves Twitter, Nando's and the city of Leicester in the UK to challenge and advance ways of understanding everyday multiculturalism in an era of global migration and ethnically complex populations. [ABSTRACT FROM AUTHOR]

Aims and objectives/purpose/research questions: This study explores the linguistic resources used on Facebook (FB) by six resettled Syrian refugees in the United Kingdom. It investigates the multilingual varieties and scripts employed, their discursive functions and their role in the construction of identity/ies. Design/methodology/approach: The study employs descriptive linguistic and discourse-centred online ethnographic approaches. These are complemented with insights from interviews with the informants. Data and analysis: The data set consists of 2,036 FB posts. Multilingual posts were subjected to a two-stage analysis: the first identified the affordances of new technologies for Arabic/English bilinguals – describing the function of different languages and scripts. The second stage employed a thematic analysis to frame a subsequent investigation of the stances taken by posters to construct identities and boundaries between themselves and others. Findings/conclusions: The study reveals how FB supports the construction and negotiation of multidimensional, complex personae, particularly in countering mainstream/media representations. It is a platform on which posters are able to display bilingual creativity. Originality: This article demonstrates the affordances of social media (SM) for newly settled Syrian refugees engaging in transnational networks. It identifies, as yet, unreported bilingual creativity in varieties of Arabic and English, particularly the use of a previously unidentified script, Englarabic. It ties this analysis to the study of identity performance and negotiation, and reveals the contested status of those now living in a new nation. Significance/implications: The study reveals how Syrian refugees employ complex linguistic repertoires in computer-mediated communication (CMC). We argue that SM platforms afford a creative, ideological space for bilingual refugees, as they negotiate their multiple identities online following resettlement. The study identifies linguistic innovation, particularly in the use of code-switching and Englarabic. It has implications for all those researching multilingual CMC creativity and identity, as well as those involved in understanding, planning for, and experiencing refugee (re)settlement. [ABSTRACT FROM AUTHOR]

Optimal oncological results and patient outcomes are achieved in surgery for early breast cancer with breast conserving surgery (BCS) where this is appropriate. A limitation of BCS occurs when cancer is present at, or close, to the resection margin – termed a 'positive' margin – and re-excision is recommended to reduce recurrence rate. This is occurs in 17% of BCS in the UK and there is therefore a critical need for a way to assess margin status intraoperatively to ensure complete excision with adequate margins at the first operation. This study presents the potential of high wavenumber (HWN) Raman spectroscopy to address this. Freshly excised specimens from thirty patients undergoing surgery for breast cancer were measured using a surface Raman probe, and a multivariate classification model to predict normal versus tumour was developed from the data. This model achieved 77.1% sensitivity and 90.8% specificity following leave one patient out cross validation, with the defining features being differences in water content and lipid versus protein content. This demonstrates the feasibility of HWN Raman spectroscopy to facilitate future intraoperative margin assessment at specific locations. Clinical utility of the approach will require further research. [ABSTRACT FROM AUTHOR]

Clonal hematopoiesis (CH)—age-related expansion of mutated hematopoietic clones—can differ in frequency and cellular fitness by CH type (e.g., mutations in driver genes (CHIP), gains/losses and copy-neutral loss of chromosomal segments (mCAs), and loss of sex chromosomes). Co-occurring CH raises questions as to their origin, selection, and impact. We integrate sequence and genotype array data in up to 482,378 UK Biobank participants to demonstrate shared genetic architecture across CH types. Our analysis suggests a cellular evolutionary trade-off between different types of CH, with LOY occurring at lower rates in individuals carrying mutations in established CHIP genes. We observed co-occurrence of CHIP and mCAs with overlap at TET2, DNMT3A, and JAK2, in which CHIP precedes mCA acquisition. Furthermore, individuals carrying overlapping CH had high risk of future lymphoid and myeloid malignancies. Finally, we leverage shared genetic architecture of CH traits to identify 15 novel loci associated with leukemia risk. Types of clonal hematopoiesis (CH) differ in frequency and fitness. These findings uncover shared genetic architecture, suggest evolutionary trade-offs between CH types, and detail elevated leukemia risk in individuals with overlapping types of CH. [ABSTRACT FROM AUTHOR]

Michael Hand has recently challenged certain religious organisations that run Academies in the United Kingdom to devise and pursue their own faith-based curricula in their schools. In this short article I examine some of the problems Hand's challenge might encounter, including whether religious conceptions of worthwhile activities and of human flourishing can be as devoid of religious beliefs as Hand would seem to wish and whether his challenge can be met.

This article investigates the extent to which Year One B.Ed student teachers arrived at university already possessing self-confidence as writers. Both quantitative and qualitative methods of data collection were used to identify students' self perceptions and confidence as writers and their understanding of processes of written composition. The article argues that to consciously engage student teachers in the writing process and to require them to reflect on that process can lead to their self efficacy as writers. Evidence from this study suggests one's self-confidence, as a writer, is enhanced by explicitly engaging in self reflection of one's own approaches to writing. The findings have implications for course design of literacy components in teacher education internationally.

This study aimed to consider collaborative practice in contributing to joint assessment and producing appropriate referral of children to speech and language therapy (SLT). Results of formal testing of selected comprehension skills are compared with functional/classroom performance as rated by class teachers. Thirty children aged 6.5-8.4 years, from three mainstream schools, were assessed using Clinical Evaluation of Language Fundamentals (CELF-4; Semel et al., 2006) subtests: "Understanding Spoken Paragraphs" and "Concepts and Directions." The children's teachers completed the "listening" component of the Observational Rating Scale. Combined scores for Understanding Spoken Paragraphs and Concepts and Directions subtests are significantly correlated with Observational Rating Scale scores, which reflect teachers' ratings of comprehension in the classroom. The Concepts and Directions subtest scores alone correlated significantly with the teachers' Observational Rating Scale ratings, but the Understanding Spoken Paragraphs scores did not. The findings suggest that teachers can fairly accurately identify the level of children's functioning from informal observations, and these were corroborated through standardized speech and language therapy assessment. It is argued that holistic assessment and collaboration between health and education professionals can provide the basis for appropriate referral and effective assessment, contributing to accurate profiling and monitoring of intervention.

This study investigated the engagement with writing of reluctant writers in the contexts of home and school. A structured and semi-structured survey method was used to capture responses from 106 reluctant writers in 9 primary schools (age range 6--9 year olds) in the UK. Findings show that although these students were deemed to be reluctant writers by their teachers, the majority admitted to writing in a range of genres in the home context. It was found that these students had access to adult help with their writing in the home and also had ready-made audiences. A sociocultural perspective is used to explain the discontinuity in the writing behaviours of these students between home and school. The implications of this study are applicable to societies with highly prescriptive writing curricula in which transcriptional writing skills are privileged over creativity and compositional processes. The corollary is that schools need to adopt ethnographic approaches to literacy in order to capture the varied identities of students as writers, and provide the means by which students can freely apply literacy practices developed in the home to writing in school. (Contains 4 figures.)

Evidence from recent research suggests that in the UK the public perception of errors in national examinations is that they are simply mistakes; events that are preventable. This perception predominates over the more sophisticated technical view that errors arise from many sources and create an inevitable variability in assessment outcomes. The public perception also seems to invest assessment grades and marks with the precision and accuracy of scientific measurements; a perception that does not sit easily with the academic and professional understanding that grades and marks are assigned rather than measured. However, growing numbers of successful challenges by students to their examination results present an interesting challenge for examination bodies. Such evidence could point to a number of possible causes. For example, there might be an increasing awareness among students of the uncertainty surrounding the grades assigned to their work; or their confidence in the capacity of such assessments to reflect the true quality of their performance may be decreasing. As the numbers of challenges increase year on year, there is growing consensus among assessment experts that public confidence needs to be strengthened. Clearly this may be achieved in a number of ways, e.g. by reducing the incidence of human errors and system breakdowns or by improving the public understanding of the assessment process. The latter tactic prompts calls for greater openness and transparency in all aspects of assessment design and process. However, such calls rarely touch on one of the most enduring dimensions of the problem: the public's perception of precision and accuracy in educational assessments. This paper argues that this problem partly arises from a misuse of the term "measurement" in educational assessment and that in addition to openness and transparency, any public understanding strategy should seek to reduce the misconceptions it causes. (Contains 3 tables and 3 notes.)

Active bone-conducting hearing devices (aBCHD; e.g., MEDEL Bonebridge® (BB)) and active middle ear implants (aMEI; e.g., MEDEL Vibrant Soundbridge® (VSB)) use radio frequency transmission to send information from an external microphone and sound processor to an internally implanted transducer. These devices potentially have an advantage over devices with percutaneous links because the skin is closed over the implantable components, which should reduce the risk of skin problems and infection. On the other hand, surgical procedures are more complex, with a greater risk of damage due to surgery. The objectives of this research were to quantify the reliability and long-term survival of MEDEL VSB and BB devices, determine the adverse and serious adverse device-related complications, and consider associated causes. A multi-center observational retrospective and prospective study was conducted at eleven auditory implant centers in the United Kingdom. Data was collected using a surgical questionnaire and audiological reports. Data were obtained from patient notes or from prospective cases that had a minimum follow-up of one year post-implant. Consecutive patient records were reviewed. Datasets from 109 BB and 163 VSB were reviewed. Of these, 205 were retrospective case note reviews, and 67 were prospective cases. The mean follow-up was 4 and 6 years, respectively, for BB and VSB. Kaplan–Meier Survival analyses indicated that the BB survival was 97% and 93.3% at 1 and 5 years, respectively, and the VSB was 92.1% and 87% at the same time points. This is a large cohort study for the field and has indicated that BB and VSB are safe interventions. Care should be taken to monitor magnet strength in the first few months. For the majority of device-related effects, there was no apparent association with etiology. However, an interesting pattern emerged for individuals who exhibited an inflammatory response, e.g., adhesions or device extrusion, and those with a history of chronic suppurative otitis media. This should be considered in future work and is not surprising given that many VSB recipients have a complicated hearing history, often associated with otitis media. [ABSTRACT FROM AUTHOR]

This article contributes to the international comparative analysis of university venture capital (UVC), providing a quasi-experimental design for follow-up research and practice. The US venture capital industry, with its unicorn focused high-growth format opened up a venture capital gap. UVC transmutes academic innovation into high-tech firms, industries and regional renewal, filling interstitial funding gaps among angel, public and private venture capital offers. It is a knowledge-based industrial policy by Another Name, with direct/explicit and indirect/implicit versions, on a continuum with variation depending upon shifting ideological and competitive concerns. Beyond as of right "womb" provision, UVC capstones an academic innovation ecosystem of technology transfer, incubation and acceleration, translational research, proof of concept funds and entrepreneurship education. Venture capital, exemplified by Sand Hill Road, de-emphasizes classic regional development objectives, neglecting appropriability conditions such as academic and regional circumstances that UK and China prioritize. More modest firm formation outcomes are dismissed as failures, with entrepreneurs encouraged to return to the entrepreneurial churn. We examine the origin and development of UVC from macro, meso and micro, historical and comparative perspectives. Multi-method/multi-sample, comparative case study, and big data analytics show the constraint, variety, and early affinity of UVC to academic icons with significant untapped potential to inspire widespread economic and social advance. [ABSTRACT FROM AUTHOR]

Robust control of skilled actions requires the flexible combination of multiple sources of information. Here we examined the role of gaze during high-speed locomotor steering and in particular the role of feedback from the visible road edges. Participants were required to maintain one of three lateral positions on the road when one or both edges were degraded (either by fading or removing them). Steering became increasingly impaired as road edge information was degraded, with gaze being predominantly directed toward the required road position. When either of the road edges were removed, we observed systematic shifts in steering and gaze direction dependent upon both the required road position and the visible edge. A second experiment required fixation on the road center or beyond the road edges. The results showed that the direction of gaze led to predictable steering biases, which increased as road edge information became degraded. A new steering model demonstrates that the direction of gaze and both road edges influence steering in a manner consistent with the flexible weighted combination of near road feedback information and prospective gaze information. (Contains 2 tables, 11 figures and 7 footnotes.)

Academic literacies research has tended to focus on writers in context, while systemic functional linguistic research has tended to focus on texts in context. While literacy practices and written texts may be usefully analysed independently, this paper describes how an investigation of genres of academic writing in the BAWE (British Academic Written English) corpus draws on an exploration of the social context of assessed student writing in order to support the analysis of texts with an IMRD (Introduction, Methods, Results, Discussion) type structure as members of either the Research Report or Methodology Recount genre family. It also illustrates how register analysis in SFL allows the analyst to gain insights into disciplinary contexts and ideologies through a comparison of extracts from the methods sections of corpus linguistics, psychology and chemistry assignment texts. The paper not only shows how research into writing practices and participant perspectives is combined with text analysis in one project, but also argues that an understanding of both is essential for the application of research findings in teaching EAP. (Contains 6 tables.)

Following its late nineteenth-century emergence as an important element within federalist thinking across the British Empire, the idea of Greater Britain lost much of its political force in the years following the Boer War. The concept however continued to retain considerable residual currency in other fields of Imperial debate, including those concerning policies and practices of education across the Empire. This paper explores aspects of such debate by examining the intellectual contexts, theoretical assertions and conceptual formulations deployed in relation to questions about education, leadership, Imperial unity and racial identity in the early twentieth century. These issues are illuminated by an analysis of proposals by the Imperial theorist E.B. Sargant for the educational "colonisation" of the Empire of white settlement by "daughter" schools transposed from the traditional public schools of the metropole and staffed by teachers conceived as "the regulars of the State". (Contains 131 footnotes.)

This study examines the differences in the interpretation of ten "in context" verbal probability expressions used in accounting standards between native Chinese speaking and native English speaking accounting students in United Kingdom universities. The study assesses the degree of grouping factors consensus on the numerical interpretation of the probability expressions. Unlike previous studies, this study uses subjects who share a common language (English), respond to a survey written in the common language, and are being educated in that common language. The results show that native culture and language are not significant factors in explaining differences between accounting students in their interpretation of "in context" verbal probability expressions. Future research comparing Chinese students in China with Chinese students at English speaking universities would be useful in evaluating the extent that common language and cultural differences has on the results. (Contains 2 tables and 5 footnotes.)

This article argues that most variants of professional development in information and communications technologies are merely "in-between" processes, the design of which does not pay sufficient attention to important antecedent and post-engagement activities. These we identify as preparing the ground before the main engagement with the teachers begins, and enabling teachers to make and sustain their own progress after it is complete. Using two empirical case studies, this article sets out to explore, from a primarily UK perspective, the two-fold process of "striking the chord" of teachers' interest and commitment as precursors to change, and pursuing sustainability once the face-to-face role of conventional professional development has ended. (Contains 2 figures.)

What is the responsibility of an educator--where does it begin and end? We report on a study of teachers at four admired public high schools in urban areas in the US. The teachers describe their deep commitment to meeting students' academic needs, as well as their developmental, social and emotional needs. The ways these teachers construe responsibility requires them to be creative, innovative and flexible inside and outside of the classroom. However, this broad conceptualization puts them at odds with current signals from the larger society, which define their responsibilities narrowly, calling for a focus primarily on the academic needs of students. Despite this tension, many urban teachers work tirelessly to connect with students personally to find new ways to satisfy students' needs--indeed this is how the teachers ultimately derive meaning from their work. With minimal guidance about how to carry out what they see as "good work", teachers set their own goals and expectations, while also aiming to meet the school, state, and national standards. Teachers worry that at some point in the future, without support from the field, they will not be able to sustain their energy and passion for this challenging work. We focus on how these urban teachers describe and define responsibility in their work, the relationship between responsibility and creativity, challenges teachers face to sustain this work, and how these factors impact teaching as a formal profession. (Contains 7 notes.)

Background: Despite a large body of evidence regarding reliable indicators of language deficits in young children, there has not been a standardized, quick screen for language impairment. The Grammar and Phonology Screening (GAPS) test was therefore designed as a short, reliable assessment of young children's language abilities. Aims: GAPS was designed to provide a quick screening test to assess whether pre-and early school entry children have the necessary grammar and pre-reading phonological skills needed for education and social development. This paper reports the theoretical background to the test, the pilot study and reliability, and the standardization. Methods: This 10-min test comprises 11 test sentences and eight test nonsense words for direct imitation and is designed to highlight significant markers of language impairment and reading difficulties. To standardize the GAPS, 668 children aged 3.4-6.6 were tested across the UK, taking into account population distribution and socio-economic status. The test was carried out by a range of health and education professionals as well as by students and carers using only simple, written instructions. Results: GAPS is effective in detecting a range of children in need of further in-depth assessment or monitoring for language difficulties. The results concur with those from much larger epidemiological studies using lengthy testing procedures. Conclusions: The GAPS test (1) provides a successful screening tool; (2) is designed to be administered by professionals and non-professionals alike; and (3) facilitates identification of language impairment or at-risk factors of reading impairment in the early educational years. Thus, the test affords a first step in a process of assessment and targeted intervention to enable children to reach their potential. (Contains 12 tables and 4 figures.)

Background : In the wake of Covid-19, the prevalence of working from home ('home-working') is expected to rise. Yet, working from home can have negative health and wellbeing impacts. Interventions are needed to promote effective ways of working that also protect workers' health and wellbeing. This study explored the feasibility and acceptability of an intervention intended to promote home-working practices that would protect and promote health behaviour and wellbeing. Methods: An uncontrolled, single-arm mixed-methods trial design was employed. Forty-two normally-office-based UK workers, working from home between January–February 2021 (during the Covid pandemic), consented to receive the intervention. The intervention: a digital document offering evidence-based recommendations for home-working in ways conducive to health behaviour and wellbeing. Feasibility and acceptability were quantitatively indexed by: expressions of interest within 1 week (target threshold ≥ 35); attrition across the one-week study period (threshold ≤ 20%); and the absence of any apparent detriments in self-reported physical activity, sedentary behaviour, snacking, and work-related wellbeing prior to and one week after receiving the intervention. Qualitative think-aloud data, obtained while participants read through the intervention, and analysed using reflexive thematic analysis, explored acceptability. Semi-structured interviews conducted one week after intervention exposure were content-analysed to identify whether and which behaviour changes were adopted. Results: Two feasibility criteria were met: 85 expressions of interest indicated satisfactory intervention demand, and no detriments were observed in health behaviours or wellbeing. Forty-two participants (i.e., maximum capacity for the study; 26 females, 16 males, aged 22–63) consented to take part. 31% dropped out over the one-week study period leaving a final sample of 29 (18 females, 11 males, aged 22–63), exceeding identified attrition thresholds. Think-aloud data showed that participants concurred with intervention guidance, but felt it lacked novelty and practicality. Follow-up interviews produced 18 (62%) participant reports of intervention adherence, where nine recommendations reportedly prompted behaviour change in at least one participant. Conclusions: Mixed evidence was found for intervention feasibility and acceptability. Whilst the information was deemed relevant and of value, further development is required to increase its novelty. It may also be more fruitful to provide this information via employers, to encourage and emphasise employer endorsement. [ABSTRACT FROM AUTHOR]

Aims: People with pre‐diabetes are at high risk of progressing to type 2 diabetes. This progression is not well characterised by ethnicity, deprivation and age, which we describe in a large cohort of individuals with pre‐diabetes. Methods: A retrospective cohort study with The Health Improvement Network (THIN) database was conducted. Patients aged 18 years and over and diagnosed with pre‐diabetes [HbA1c 42 mmol/mol (6.0%) to 48 mmol/mol (6.5%) were included]. Cox proportional hazards regression was used to calculate adjusted hazard rate ratios (aHR) for the risk of progression from pre‐diabetes to type 2 diabetes for each of the exposure categories [ethnicity, deprivation (Townsend), age and body mass index (BMI)] separately. Results: Of the baseline population with pre‐diabetes (n = 397,853), South Asian (aHR 1.31; 95% CI 1.26–1.37) or Mixed‐Race individuals (aHR 1.22; 95% CI 1.11–1.33) had an increased risk of progression to type 2 diabetes compared with those of white European ethnicity. Likewise, deprivation (aHR 1.17; 95% CI 1.14–1.20; most vs. least deprived) was associated with an increased risk of progression. Both younger (aHR 0.63; 95% CI 0.58–0.69; 18 to <30 years) and older individuals (aHR 0.85; 95% CI 0.84–0.87; ≥65 years) had a slower risk of progression from pre‐diabetes to type 2 diabetes, than middle‐aged (40 to <65 years) individuals. Conclusions: South Asian or Mixed‐Race individuals and people with social deprivation had an increased risk of progression from pre‐diabetes to type 2 diabetes. Clinicians need to recognise the differing risk across their patient populations to implement appropriate prevention strategies. [ABSTRACT FROM AUTHOR]

Wheat is a major crop worldwide, mainly cultivated for human consumption and animal feed. Grain quality is paramount in determining its value and downstream use. While we know that climate change threatens global crop yields, a better understanding of impacts on wheat end‐use quality is also critical. Combining quantitative genetics with climate model outputs, we investigated UK‐wide trends in genotypic adaptation for wheat quality traits. In our approach, we augmented genomic prediction models with environmental characterisation of field trials to predict trait values and climate effects in historical field trial data between 2001 and 2020. Addition of environmental covariates, such as temperature and rainfall, successfully enabled prediction of genotype by environment interactions (G × E), and increased prediction accuracy of most traits for new genotypes in new year cross validation. We then extended predictions from these models to much larger numbers of simulated environments using climate scenarios projected under Representative Concentration Pathways 8.5 for 2050–2069. We found geographically varying climate change impacts on wheat quality due to contrasting associations between specific weather covariables and quality traits across the UK. Notably, negative impacts on quality traits were predicted in the East of the UK due to increased summer temperatures while the climate in the North and South‐west may become more favourable with increased summer temperatures. Furthermore, by projecting 167,040 simulated future genotype–environment combinations, we found only limited potential for breeding to exploit predictable G × E to mitigate year‐to‐year environmental variability for most traits except Hagberg falling number. This suggests low adaptability of current UK wheat germplasm across future UK climates. More generally, approaches demonstrated here will be critical to enable adaptation of global crops to near‐term climate change. [ABSTRACT FROM AUTHOR]

Clergy from several Christian denominations in the UK were invited to participate in an online survey which explored their experience of pastoral/reflective supervision. The research question was, "How has the practice of pastoral supervision within Christian denominations in the UK been beneficial, and what have been its limitations?" The aims of the research were: to explore what has been helpful to supervisees in the provision of pastoral supervision; and to determine what has not been helpful to supervisees in the provision of pastoral supervision. 173 clergy respondents took part. The data show that pastoral/reflective supervision is mostly beneficial to respondents, and that pastoral/reflective supervision enables clergy to self-perceive feelings of: support; lessening isolation; increased insight into personal process; affirmation of their ministry; and to have a better sense of wellbeing. Some hindrances to effective supervision are identified, and some recommendations for training and denominational support are made. [ABSTRACT FROM AUTHOR]

The retailing industry in the UK is experiencing unprecedented structural change. The impact on retailers has often dominated headlines, along with the impacts on local services and economies, but with little attention given to the implications for property owners and practitioners. Exploring and understanding the responsiveness of landlords, and their behaviours, is essential to understanding the adaptiveness of a retailing system. This study employs semi-structured interviews to examine the short- and long-term changes in the retail market and the actions of landlords in response. The findings span the period prior to and during the first year of the Covid-19 pandemic in 2020, and reveal that fundamental changes have occurred to establish tenant covenant norms and the traditional retail leasing model. The paper explores these changes, including a shift in tenant risk, reposition of the leasing model in favour of tenants, generally, and greater application of turnover rents. The pressing challenge for current valuation practitioners, therefore, is to incorporate these fundamental changes within the market into the pricing of retail assets. Significant progress in this area to date, as explored in the paper, has been limited although greater application of discounted cashflow techniques is set to be encouraged by the RICS. [ABSTRACT FROM AUTHOR]

This article considers whether there are underlying problems in research into information and communications technology (ICT) and reflects specifically on the call for researchers to use quantitative methods more in their work. Reasons for potential weaknesses in educational and, more specifically, ICT research are discussed and the "quantitative deficit" is considered in the light of such key issues as "fitness for purpose". ICT research needs somehow to create a measure of freedom from the pressure to examine immediate-term issues relating to ICT policy and practice. More time and appropriate research activities need to be found if we are to lay better foundations for theory building from a more cumulative and coherent research base. The authors contend that the debate about whether to use quantitative or qualitative methods is barren, and that the fit-for-purpose principle should be the central issue in methodological design. The article concludes by calling for all ICT research to reflect the principles of disciplined inquiry: ensuring that we tell our research stories better, by making our evidence explicit and the basis of our arguments open to full scrutiny. (Contains 1 table.)