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Editorial. Calls for early detection of high serum cholesterol levels in young adults. Presentation of arguments for and against testing for high serum cholesterol; Refutation of arguments against early detection; Presentation of possible reasons doctors do not engage in early detection; Risks of not detecting high serum cholesterol early; Suggestion of early detection guidelines.

Objectives: To determine the incidence of lung cancer amongst primary care referrals for investigation with a chest radiograph (CXR)., Methods: Retrospective evaluation of datasets from the national Clinical Practice Research Datalink (CPRD) and from a single large regional centre. Data were extracted for cohorts of consecutive adults aged over 40 years for whom a CXR had been performed between 2016 and 2018. Using cancer registry data, the incidence of lung cancer within a 2 years of the CXR referral and the variations with age, gender, and smoking status were evaluated., Results: A total of 291 294 CXR events were evaluated from the combined datasets. The incidence of lung cancer amongst primary care CXR referrals was 1.4% in CPRD with a consistent correlation with increasing age and smoking status. The incidence of lung cancer within two-years of the CXR varied between 0.03% (95%CI, 0.0-0.1) amongst never smokers aged 40-45 years to 4.8% (95%CI, 4.2-5.5) amongst current-smokers aged 70-75 years. The findings were similar for the single large centre data, although cancer incidence was higher., Conclusions: A simple estimation and stratification of the risk of lung cancer amongst primary care referrals for investigation with a CXR is possible using age and smoking status., Advances in Knowledge: This is the first estimate of the incidence of lung cancer amongst primary care CXR referrals and a demonstration of how the demographic information contained within a request could be used to optimize investigations and interpret test results., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Institute of Radiology.)