1. Psoriasis: a brief overview.
- Author
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Raharja, Antony, Mahil, Satveer K., and Barker, Jonathan N.
- Subjects
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PSORIASIS treatment , *THERAPEUTIC use of vitamin D , *PSORIASIS , *PSORIATIC arthritis , *MEDICAL radiology , *RETINOIDS , *INTERLEUKINS , *SMALL molecules , *ADRENOCORTICAL hormones , *PHOTOTHERAPY , *CONTINUING education units , *HOLISTIC medicine , *METHOTREXATE , *HEALTH care teams , *CYCLOSPORINS , *TUMOR necrosis factors , *INTEGRATED health care delivery , *COMORBIDITY , *ULTRAVIOLET radiation , *SYMPTOMS - Abstract
Psoriasis is a clinically heterogeneous lifelong skin disease that presents in multiple forms such as plaque, flexural, guttate, pustular or erythrodermic. An estimated 60 million people have psoriasis worldwide, with 1.52% of the general population affected in the UK. An immune-mediated inflammatory disease, psoriasis has a major genetic component. Its association with psoriatic arthritis and increased rates of cardiometabolic, hepatic and psychological comorbidity requires a holistic and multidisciplinary care approach. Psoriasis treatments include topical agents (vitamin D analogues and corticosteroids), phototherapy (narrowband ultraviolet B radiation (NB-UVB) and psoralen and ultraviolet A radiation (PUVA)), standard systemic (methotrexate, ciclosporin and acitretin), biologic (tumour necrosis factor (TNF), interleukin (IL)-17 and IL-23 inhibitors) or small molecule inhibitor (dimethyl fumarate and apremilast) therapies. Advances in the understanding of its pathophysiology have led to development of highly effective and targeted treatments. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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