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[Display omitted] • This is the first known study to detect anti- Toxocara antibodies in the tissue exudates of animals. • 27.7% of tissue exudate samples were positive for anti- Toxocara antibodies. • Pigs were more likely to be positive for anti- Toxocara antibodies (at 10% significance) • Tissue exudate serology of meat products could be applied in support of food safety. Toxocara canis and Toxocara cati are globally distributed, zoonotic roundworm parasites. Human infection can have serious clinical consequences including blindness and brain disorders. In addition to ingesting environmental eggs, humans can become infected by eating infective larvae in raw or undercooked meat products. To date, no studies have assessed the prevalence of Toxocara spp. larvae in meat from animals consumed as food in the UK or assessed tissue exudates for the presence of anti- Toxocara antibodies. This study aimed to assess the potential risk to consumers eating meat products from animals infected with Toxocara spp. Tissue samples were obtained from 155 different food producing animals in the south, southwest and east of England, UK. Tissue samples (n = 226), either muscle or liver, were processed by artificial digestion followed by microscopic sediment evaluation for Toxocara spp. larvae, and tissue exudate samples (n = 141) were tested for the presence of anti- Toxocara antibodies using a commercial ELISA kit. A logistic regression model was used to compare anti- Toxocara antibody prevalence by host species, tissue type and source. While no larvae were found by microscopic examination after tissue digestion, the overall prevalence of anti- Toxocara antibodies in tissue exudates was 27.7%. By species, 35.3% of cattle (n = 34), 15.0% of sheep (n = 60), 54.6% of goats (n = 11) and 61.1% of pigs (n = 18) had anti- Toxocara antibodies. Logistic regression analysis found pigs were more likely to be positive for anti- Toxocara antibodies (odds ration (OR) = 2.89, P = 0.0786) compared with the other species sampled but only at a 10% significance level. The high prevalence of anti- Toxocara antibodies in tissue exudates suggests that exposure of food animals to this parasite is common in England. Tissue exudate serology on meat products within the human food chain could be applied in support of food safety and to identify practices that increase risks of foodborne transmission of zoonotic toxocariasis. [ABSTRACT FROM AUTHOR]

Background: Toxocara canis and Toxocara cati are intestinal parasites of dogs, cats and foxes, with infected animals shedding eggs of the parasite in their faeces. If humans accidentally ingest embryonated Toxocara spp. eggs from the environment, severe clinical consequences, including blindness and brain damage, can occur. Previous work has demonstrated the presence of Toxocara spp. eggs on vegetable produce grown in the UK, but only in small-scale community gardens. The aim of this study was to determine whether Toxocara spp. eggs are also present on vegetables grown on commercial farms in the UK, which supply produce to a greater number of people. Methods: A total of 120 samples (300 g each) of spinach (Spinacia oleracea) were collected across four farms in the south of England, UK. The samples were processed using a sieving approach followed by multiplex quantitative polymerase chain reaction analysis. Results: Overall, 23.0% of samples were positive for T. canis (28/120; 95% confidence interval 16.7–31.7%) and 1.7% for T. cati (2/120; 95% confidence interval 0.5–5.9%). There was a statistically significant difference in the number of positive samples between farms (P = 0.0064). To our knowledge, this is the first report of the isolation of Toxocara spp. from vegetables grown on commercial farms in the UK. Conclusions: The results of this study highlight the requirement for the thorough washing of vegetables prior to their consumption, especially those such as spinach which may be eaten without first peeling or cooking, and effective farm biosecurity measures to minimise access to farmland by definitive host species of Toxocara spp. [ABSTRACT FROM AUTHOR]

Throughout the COVID-19 pandemic, conspiracy theories about the virus spread rapidly, and whilst governments across the globe put in place different restrictions and guidelines to contain the pandemic, these were not universally adhered to. This research examined the association between pandemic related risk perceptions, belief in conspiracy theories, and compliance with COVID-19 public guidelines amongst a UK sample (n = 368). Participants rated their level of concern for a series of potential risks during the pandemic (to the economy, personal health, freedom, media integrity and health risk to others). Participants also rated their level of belief in different conspiracy theories and self-reported their behaviour during the first UK lockdown. Mediational analyses showed that stronger belief in conspiracy theories was associated with perceptions of lower risk to health and higher risk to the economy and freedom, which in turn were associated with lower compliance with COVID-19 related governmental guidelines. Perception of information transparency risks did not mediate the association between belief in conspiracy theories and compliant behaviours. These results highlight the key role that risk perception may play in translating belief in conspiracy theories into low compliance with governmental COVID-19 related guidelines. Our findings suggest new patterns with respect to the relationship between conspiracy theory adherence and salience of different risk perceptions amidst the pandemic, which could have implications for the development of public health messaging and communication interventions. [ABSTRACT FROM AUTHOR]

Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the Genetic Epidemiology Research on Adult Health and Aging cohort (16,012 cases, 50,552 controls) and UK Biobank (48,969 cases, 359,802 controls). Within cohorts, each PRS is evaluated in multivariable logistic regression models against all other cancer types. Results are then meta-analyzed across cohorts. Ten positive and one inverse cross-cancer associations are found after multiple testing correction. Two pairs show bidirectional associations; the melanoma PRS is positively associated with oral cavity/pharyngeal cancer and vice versa, whereas the lung cancer PRS is positively associated with oral cavity/pharyngeal cancer, and the oral cavity/pharyngeal cancer PRS is inversely associated with lung cancer. Overall, we validate known, and uncover previously unreported, patterns of pleiotropy that have the potential to inform investigations of risk prediction, shared etiology, and precision cancer prevention strategies. While genetic loci shared between cancer types have been identified, cross-cancer relationships for polygenic risk scores have not been well studied. Here, the authors have developed polygenic risk scores for 16 cancers in two large cohorts and identified positive and inverse cross-cancer associations. [ABSTRACT FROM AUTHOR]

Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is genetically correlated with reduced forced expiratory volume in one second (FEV1: rg = 0.098, p = 2.3 × 10−8) and the ratio of FEV1 to forced vital capacity (FEV1/FVC: rg = 0.137, p = 2.0 × 10−12). Mendelian randomization analyses demonstrate that reduced FEV1 increases squamous cell carcinoma risk (odds ratio (OR) = 1.51, 95% confidence intervals: 1.21–1.88), while reduced FEV1/FVC increases the risk of adenocarcinoma (OR = 1.17, 1.01–1.35) and lung cancer in never smokers (OR = 1.56, 1.05–2.30). These findings support a causal role of pulmonary impairment in lung cancer etiology. Integrative analyses reveal that pulmonary function instruments, including 73 novel variants, influence lung tissue gene expression and implicate immune-related pathways in mediating the observed effects on lung carcinogenesis. The role of impaired lung function in lung cancer etiology is complex due to the relation of cigarette smoking to both conditions. Here, supported by Mendelian randomization analysis the authors find a link between pulmonary function impairment and lung cancer risk beyond smoking, implicating immune-related pathways [ABSTRACT FROM AUTHOR]

Objectives. To test whether childhood maltreatment was a predictor of (1) having low educational qualifications and (2) not being in education, employment, or training among young adults in the United Kingdom today. Methods. Participants were from the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally representative UK cohort of 2232 twins born in 1994 to 1995. Mothers reported on child maltreatment when participants were aged 5, 7, 10, and 12 years. Participants were interviewed about their vocational status at age 18 years. Results. The unadjusted odds of having low educational qualifications or of not being in education, employment, or training at age 18 years were more than 2 times greater for young people with a childhood history of maltreatment versus those without. These associations were reduced after adjustments for individual and family characteristics. Youths who reported having a supportive adult in their lives had better education outcomes than did youths who had less support. Conclusions. Closer collaboration between the child welfare and education systems is warranted to improve vocational outcomes for maltreated youths. [ABSTRACT FROM AUTHOR]

Agricultural systems that classify as 'beyond organic' have the potential to advance sustainability efforts. The present research considers these emerging systems from a consumer insights perspective. Using biodynamic (BD) agriculture as an exemplar, public opinions were explored in a multi-method and multi-national study with samples of consumers in the United Kingdom (UK), Australia, Singapore, and Germany. Across 1237 participants, the empirical findings pointed to largely positive attitudes. Between-country differences were minor, whereas consumer segmentation identified pan-national groups of people with attitudes that were, respectively, BD Positive (71%), BD Neutral (20%) or BD Negative (9%). In the BD Positive segment, consumers responded positively to the environmental and social aspects of BD agriculture, and it mattered to them that BD agriculture was a balanced and integrated approach to farming/food production. That is, they were not averse to the holistic/spiritual aspects that are unique to BD. Biodiversity, but also other aspects of environmental sustainability mattered more to consumers than social sustainability, notably worker welfare and community resilience. The research provides new consumer insights about biodynamics by being generic to BD agriculture rather than product specific (e.g., BD wine), and advances extant consumer research by jointly exploring environmental and social sustainability. Several practical implications emerge from the results. • Consumer attitudes to biodynamic (BD) agriculture were studied using online surveys. • Four countries were studied and compared: UK, Australia, Singapore, and Germany. • Attitudes towards BD agriculture were largely positive in the four countries. • Focus in BD on biodiversity and ecosystem health was highly important for consumers. • Only minor cross-cultural differences in attitudes to BD agriculture were uncovered. [ABSTRACT FROM AUTHOR]

• Importance of food choice motives (FCQ factors) varies with food neophobia (FN). • Data from online surveys in USA, UK, and Germany with 5752 adults. • Positive covariation confirmed in all three countries between FN and FCQ Familiarity. • Same for negative covariation between FN and FCQ Health and Natural Content. • Validation with stated purchase and consumption frequency for foods and beverages. It was recently shown that food neophobia (FN) shows consistent patterns of relationships with the factors from the Food Choice Questionnaire (FCQ). The data reported in Jaeger, Roigard et al. (2021) [Appetite, 105056], based on consumer surveys in USA, Australia, and New Zealand, indicate that each of 11 FCQ factors are negatively associated with FN except for Convenience and Familiarity , which were both positively associated with FN. The present study, based on online surveys with 5752 adults aimed to replicate, using another USA sample, and extend, using samples from the UK and Germany, the earlier findings. In addition, behavioural validation of the observed FN-FCQ linkages was undertaken by directly relating FN to stated frequency of selected food and beverage (F&B) purchases and consumption. The US and UK results largely replicated the findings of Jaeger, Roigard et al. (2021), and for the two exceptions found – Convenience and Weight Control – the directional relationships matched those expected. The German results also partially supported replication, in that the relationships between FN and FCQ factors were in the expected directions, but mostly they were non-significant. Examination of self-reports of F&B purchase and consumption frequencies tended to validate the observed FN-FCQ linkages with the exceptions of Convenience and Sensory Appeal (USA and UK consumers), although these linkages were less evident in the German consumers. We suggest that the concept of high arousal underlying the food choices of those high in FN may help explain why some F&B characteristics and not others reflect FN-FCQ linkages. These findings, along with those presented in Jaeger, Roigard et al. (2021) have increased knowledge about how FN and FCQ factors influence consumer choices. It is increasingly clear that FN not only influences which specific foods are consumed but also shapes the reasons for food choice itself. Understanding this link therefore allows us to predict at a more global level those reasons that influence consumers with different degrees of FN in choosing foods. [ABSTRACT FROM AUTHOR]

Background: Chaotic homes predict poor school performance. Given that it is known that genes affect both children's experience of household chaos and their school achievement, to what extent is the relationship between high levels of noise and environmental confusion in the home, and children's school performance, mediated by heritable child effects? This is the first study to explore the genetic and environmental pathways between household chaos and academic performance. Method: Children's perceptions of family chaos at ages 9 and 12 and their school performance at age 12 were assessed in more than 2,300 twin pairs. The use of child-specific measures in a multivariate genetic analysis made it possible to investigate the genetic and environmental origins of the covariation between children's experience of chaos in the home and their school achievement. Results: Children's experience of family chaos and their school achievement were significantly correlated in the expected negative direction ( r = −.26). As expected, shared environmental factors explained a large proportion (63%) of the association. However, genetic factors accounted for a significant proportion (37%) of the association between children's experience of household chaos and their school performance. Conclusions: The association between chaotic homes and poor performance in school, previously assumed to be entirely environmental in origin, is in fact partly genetic. How children's home environment affects their academic achievement is not simply in the direction environment → child → outcome. Instead, genetic factors that influence children's experience of the disordered home environment also affect how well they do at school. The relationship between the child, their environment and their performance at school is complex: both genetic and environmental factors play a role. [ABSTRACT FROM AUTHOR]

• Methodological aspects of text highlighting were studied. • Data from online survey on vertical farming (VF) with 1466 UK consumers. • Text characteristics influenced responses to text highlighting. • The text highlighting task did not influence attitudes to vertical farming. • Text highlighting results must be interpreted in the context of the provided text. Direct attitude questions occupy a central position in consumer research despite concerns over validity and reliability. Text highlighting is an alternative method where participants use highlighter functions to indicate content that they 'ike' and 'dislike' as they read a text. Jaeger et al. (2022) [Food Qual Prefer, 95, 104356] introduced this approach and the present research investigated it methodologically to further assess its potential for attitude measurement. There were two research questions (RQ) that asked whether: 1) highlighting responses are independent of text characteristics (length, content); and 2) consumers' attitudes are altered by the process of completing the highlighting task. Data were collected in an online survey on vertical farming (VF) where 1466 UK consumers took part. For RQ1, results showed that word highlighting frequency was altered by textual context and decreased for longer texts. The sentiment scores for sentences were also altered, but the characteristics about VF that consumers responded positively and negatively to were minimally influenced by text length and content. For RQ2, results showed that completion of the text highlighting task did not influence attitudes to VF, meaning that the task of highlighting did not introduce response bias. Collectively, the findings of the present research further support that text highlighting has potential for attitude measurement. [ABSTRACT FROM AUTHOR]

There has been debate in the literature as to whether: (1) the risks and benefits of genetically-modified (GM) food and agriculture are considered and determined by individuals separately or whether they are jointly determined by attitudes; (2) consumer acceptance is determined by individuals weighing up their risk and benefit perceptions in a rational, even-handed manner, or if benefit perceptions are more important than risk perceptions, and (3) certain types of risk and benefit are more important than others. Against this background, this paper assesses the categories of risks and benefits and their relative importance in determining willingness to consume. A survey was carried out to collect data on the categories of risks and benefits in the US, UK and France, and the relative importance of selected perceived risk and benefit dimensions was estimated. The findings show: risk and benefit perceptions are negatively correlated, but not perfectly and, given that regressions we performed support the proposition that benefits are more important than risks in determining willingness to consume, a strong case can be made for measuring risks and benefits separately. Almost 2/3 of consumers perceive medium to high potential benefits from GM, though the proportion is slightly lower in the UK and down to 40% in France. Nevertheless, this suggests a much higher level of support for the technology than is normally assumed. From the study, benefits are more important for consumers’ willingness to consume than perceived risks, and slightly more interviewees scored above than below the mean on willingness to consume GM food. [ABSTRACT FROM AUTHOR]

Emoji have been argued to have considerable potential for emotion research but are struggling with uptake in part because knowledge about their meaning is lacking. The present research included 24 emoji (14 facial, 10 non-facial) which were characterized using the PAD model (Pleasure-Arousal-Dominance) of human affect by 165 consumers in New Zealand and 861 consumers in the UK. The results from the two countries were remarkably similar and contributed further evidence that emoji are suitable for cross-cultural research. While significant differences between the emoji were established for each of the PAD dimensions, the mean scores differed most on the Pleasure dimension (positive to negative), then on the Arousal dimension (activated to deactivated), and lastly on the Dominance dimension (dominance to submissive). The research also directly measured the perceived appropriateness of the 24 emoji for use with foods and beverages. The emoji face savoring food, clapping hands and party popper were in the top-5 for the highest appropriateness in food and beverage context for both studies, as was a strong negative expression linked to rejection (Study 1: face vomiting; Study 2: nauseated face). On the other hand, zzz and oncoming fist were considered as the least appropriate to be used in a food and beverage context in both studies. Again, the results from the UK and NZ were in good agreement and identified similar groups of emoji as most and least suitable for food-related consumer research. [ABSTRACT FROM AUTHOR]

• Extreme groups analysis is common in food neophobia (FN) research but has limitations. • These are identified and illustrated empirically in the context of how FN impacts F&B liking. • Three FN group comparisons performed: M ± 0.5 × SD, M ± 1.0 × SD and M ± 1.5 × SD. • Full-data analysis enhances understanding of the impact of FN on F&B liking. • Full-data analysis has a stronger role to play in FN research and should be used more. The negative impact of food neophobia (FN) on food and beverage (F&B) liking/disliking is well documented. Against this backdrop, the present research sought to raise awareness of data analysis strategy in FN research. Extreme groups analysis currently dominates as evidenced from the many studies that compare groups of neophobic and neophilic consumers. However, when a variable, like FN, is naturally continuous, full-data analysis has been recommended. We present both approaches using data from online surveys in three Western countries where consumers rated degree of liking/disliking for F&B names (USA, UK and Australia, n = 3454). The first objective was to explore how results from extreme groups analysis were influenced by group extremity (more/less neophobic vs. more/less neophilic). In the case of seafood and ethnic food items, the average difference in liking score between neophobic and neophilic groups ranged from 2 to 4.5 points on the 9-pt hedonic scale depending on FN group definition (less extreme vs. more extreme). To acknowledge this influence contextualisation of degree of FN group extremity is encouraged. For example, FN groups defined by M ± 0.5 × SD and M ± 1.5 × SD should be differently named to convey greater FN extremity in the latter. In the second objective, full-data analysis was performed, treating FN as a continuous variable. Additional knowledge about the impact of FN on F&B liking/disliking beyond that from extreme groups analysis was gained. Linearity in the relationship between FN and degree of F&B liking/disliking was generally observed. Moderating factors were included in additional analyses and illustrated the possibility of accounting for participants' country of living or differences between consumer populations in overall level of FN (central location vs. online). We suggest that it may be time to rely less on extreme groups analysis in FN research, and if used that adequate justification be given and care taken to describe the FN groups to facilitate more robust interpretations and between-study comparisons. The insights and recommendations have relevance for other continuous psychological traits relating to food liking food-related consumer behaviour in general. [ABSTRACT FROM AUTHOR]

Cancer risk is determined by a complex interplay of environmental and heritable factors. Polygenic risk scores (PRS) provide a personalized genetic susceptibility profile that may be leveraged for disease prediction. Using data from the UK Biobank (413,753 individuals; 22,755 incident cancer cases), we quantify the added predictive value of integrating cancer-specific PRS with family history and modifiable risk factors for 16 cancers. We show that incorporating PRS measurably improves prediction accuracy for most cancers, but the magnitude of this improvement varies substantially. We also demonstrate that stratifying on levels of PRS identifies significantly divergent 5-year risk trajectories after accounting for family history and modifiable risk factors. At the population level, the top 20% of the PRS distribution accounts for 4.0% to 30.3% of incident cancer cases, exceeding the impact of many lifestyle-related factors. In summary, this study illustrates the potential for improving cancer risk assessment by integrating genetic risk scores. Predicting cancer risk requires large datasets and sophisticated models. Here the authors integrate polygenic risk scores and modifiable risk factors for multiple cancers in the UK Biobank, improving general risk prediction and distinguishing cases where genetic or lifestyle factors have stronger associations. [ABSTRACT FROM AUTHOR]

Deciphering the shared genetic basis of distinct cancers has the potential to elucidate carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we undertake genome-wide association studies (GWAS) and comprehensive evaluations of heritability and pleiotropy across 18 cancer types in two large, population-based cohorts: the UK Biobank (408,786 European ancestry individuals; 48,961 cancer cases) and the Kaiser Permanente Genetic Epidemiology Research on Adult Health and Aging cohorts (66,526 European ancestry individuals; 16,001 cancer cases). The GWAS detect 21 genome-wide significant associations independent of previously reported results. Investigations of pleiotropy identify 12 cancer pairs exhibiting either positive or negative genetic correlations; 25 pleiotropic loci; and 100 independent pleiotropic variants, many of which are regulatory elements and/or influence cross-tissue gene expression. Our findings demonstrate widespread pleiotropy and offer further insight into the complex genetic architecture of cross-cancer susceptibility. Pleiotropic loci and genome-wide genetic correlations have identified shared heritability across some types of cancers. Here, the authors perform genome-wide association studies and characterize pan-cancer heritability and pleiotropy in individuals of European ancestry across 18 cancer types from two large cohorts. [ABSTRACT FROM AUTHOR]

This paper investigates Willingness to Accept (WTA) Genetic Modification (GM) foods based on experimental auctions carried out in the USA, UK and France. It explores perceptions of risk and benefits, moral concerns and their antecedents, attitudes to the environment and technology and trust in various sources using Structural Equation Modelling (SEM). Trust in information provided by industry proved to be the most important determinant of risk/benefit perceptions and WTA followed by general attitudes to the environment and technology. Education and age are also enhance perceived benefits and lower perceived risks of GM. Perception of risk/benefit and moral concerns all have significant effects on consumers' WTA but the perceived benefits are most important. The research suggests that trust-building by industry would be the most effective in enhancing GM acceptance. [ABSTRACT FROM AUTHOR]

Major changes are needed both with regard to what we eat and how food is produced. The latter is the focus of the present research, specifically the rise of controlled environment agriculture. In this context, empirical research is presented on consumer attitudes to vertical farming (VF) (i.e., indoor plant factory with artificial lighting), conducted in four countries (USA, UK, Singapore, and China) using online surveys (637-683 participants per country with matched gender and age group distributions). A multi-method research approach was used, including a novel methodology of text highlighting, which requires that participants read a descriptive text about VF with mentions of pros and cons and use highlighter functions to select aspects of the text that they 'like' and 'dislike'. Based on the information provided in the text, attitudes towards VF were largely positive in the four countries. The characteristics of VF that aligned with the United Nations Sustainable Development Goals were identified as key drivers of positive attitudes (i.e., higher yield, reduction of carbon emissions, and securing access to food). On the other hand, high energy use and premium prices contributed to negative attitudes about VF. Although the majority of participants responded to the text with an overall positive attitude towards VF, there were smaller groups of participants in every country who expressed a negative or neutral/ambivalent attitude. These between-segment differences were larger than cross-cultural differences, although the latter did exist, particularly for selected aspects of VF. For example, Chinese participants tended to be the least negative about the use of robots to help planting and harvesting. Future research is needed to understand consumer responses to aspects VF not covered in the text (e.g., powering VF with renewable energy, product range), and consumer insights about VF should be sought in other countries., (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Background: Social support has been shown to be associated with a reduced likelihood of developing psychotic experiences in the general population and even amongst those at high risk due to exposure to multiple forms of victimisation (poly-victimised). However, it is unclear whether this association is merely due to the confounding effects of shared environmental and genetic influences, or reverse causality. Therefore, we investigated whether social support has a unique environmentally mediated effect on adolescent psychotic experiences after accounting for familial factors, including genetic factors, and also prior psychopathology., Methods: Participants were from the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally-representative cohort of 2232 UK-born twins. Adolescents were interviewed at age 18 about psychotic experiences and victimisation exposure since age 12, and their perceptions of social support. Prior childhood mental health problems and psychotic symptoms were assessed at age 12. The discordant twin method was used to disentangle the relative family-wide and unique-environmental effects of social support on psychotic experiences in the general population and among poly-victimised adolescents., Results: Perceived social support, particularly from friends, was found to have a unique environmentally mediated buffering effect on adolescent psychotic experiences in the whole sample and in the high-risk poly-victimised group., Conclusions: The protective effects of social support on adolescent psychotic experiences cannot be accounted for by shared environmental or genetic factors, nor by earlier psychopathology. Our findings suggest that early intervention programmes focused on increasing perceptions of social support have the potential to prevent the emergence of psychotic experiences amongst adolescents.

Asherson and Agnew-Blais review evidence from prospective, longitudinal studies in Brazil, New Zealand, Sweden, the United Kingdom and the United States showing that ADHD can emerge for the first time in adolescence or young adulthood. These findings defy conventional wisdom specifying that ADHD is, by definition, a disorder that emerges in childhood. We discuss possible explanations for the late-onset of ADHD, including the removal in adolescence or young adulthood of features of a young person's environment that played a buffering role against the emergence of symptoms and heterotypic continuity in a general liability to psychopathology that is present from childhood., (© 2019 Association for Child and Adolescent Mental Health.)