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Your search keyword '"Androgen Receptor Antagonists pharmacology"' showing total 2 results
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2 results on '"Androgen Receptor Antagonists pharmacology"'

1. Selective Androgen Receptor Modulators-Transformative Drugs or Heralds of the Next Drug Epidemic?

Author

Hahamyan HA and Basaria S

Subjects
Humans, Male, Androgen Receptor Antagonists adverse effects, Androgen Receptor Antagonists pharmacology, Androgen Receptor Antagonists therapeutic use, Receptors, Androgen drug effects, Receptors, Androgen physiology, United States, Drug Approval, Nonsteroidal Anti-Androgens adverse effects, Nonsteroidal Anti-Androgens pharmacology, Nonsteroidal Anti-Androgens therapeutic use, Prostate drug effects, Musculoskeletal System drug effects, Clinical Trials as Topic, Androgen Antagonists adverse effects, Androgen Antagonists pharmacology, Androgen Antagonists therapeutic use, Substance-Related Disorders etiology, Testosterone pharmacology, Testosterone physiology, Testosterone therapeutic use
Published
2024
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2. Darolutamide: First Approval.

Author

Markham A and Duggan S

Subjects
Androgen Receptor Antagonists chemistry, Antineoplastic Agents chemistry, Clinical Trials, Phase III as Topic, Humans, Male, Pyrazoles chemistry, United States, Androgen Receptor Antagonists pharmacology, Antineoplastic Agents pharmacology, Drug Approval, Prostatic Neoplasms drug therapy, Pyrazoles pharmacology, Receptors, Androgen metabolism
Abstract

Darolutamide (NUBEQA™) is a structurally distinct non-steroidal androgen receptor antagonist being developed by Orion and Bayer as a treatment for prostate cancer. Based on positive results in the phase III ARAMIS trial, darolutamide was recently approved in the USA for the treatment of men with non-metastatic castration-resistant prostate cancer. This article summarizes the milestones in the development of darolutamide leading to this first approval.

Published
2019
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