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Proteomics has emerged as a powerful tool for studying cancer biology, developing diagnostics, and therapies. With the continuous improvement and widespread availability of high-throughput proteomic technologies, the generation of large-scale proteomic data has become more common in cancer research, and there is a growing need for resources that support the sharing and integration of multi-omics datasets. Such datasets require extensive metadata including clinical, biospecimen, and experimental and workflow annotations that are crucial for data interpretation and reanalysis. The need to integrate, analyze, and share these data has led to the development of NCI's Proteomic Data Commons (PDC), accessible at https://pdc.cancer.gov. As a specialized repository within the NCI Cancer Research Data Commons (CRDC), PDC enables researchers to locate and analyze proteomic data from various cancer types and connect with genomic and imaging data available for the same samples in other CRDC nodes. Presently, PDC houses annotated data from more than 160 datasets across 19 cancer types, generated by several large-scale cancer research programs with cohort sizes exceeding 100 samples (tumor and associated normal when available). In this article, we review the current state of PDC in cancer research, discuss the opportunities and challenges associated with data sharing in proteomics, and propose future directions for the resource., Significance: The Proteomic Data Commons (PDC) plays a crucial role in advancing cancer research by providing a centralized repository of high-quality cancer proteomic data, enriched with extensive clinical annotations. By integrating and cross-referencing with complementary genomic and imaging data, the PDC facilitates multi-omics analyses, driving comprehensive insights, and accelerating discoveries across various cancer types., (©2024 The Authors; Published by the American Association for Cancer Research.)

Using the controversy surrounding marriage with a deceased wife’s sister that occupied Presbyterian and Congregationalist theologians of the early Republic, this essay explores the eroticization of the sentimental family and the contours and crises of the incest prohibition in the wake of the Revolution. The essay begins by tracing the history of ecclesiastical trials of incestuous marriage in the Presbyterian church, arguing that the failure of the synods and General Assembly to offer definitive judgments of such marriages suggests a tension in the force of a transcendent incest prohibition. Two cases from the late 1820s, in particular, gained national attention in both the theological and secular press, and force the Presbyterian church to explore the legitimacy of their incest prohibition, and exploration that lead, ultimately, to a constriction of the incest prohibition as written in the Westminster confession of Faith. I then turn to the conjunction of kinship, sexuality, and sentiment that animates the texts comprising the controversy and argue that, in an effort to defend an expansive interpretation of the Levitical incest prohibitions these theologians were among the earliest writers to argue that sentimental, affectionate relations between family members were inherently erotic. In this sense, the family becomes the primary site for the deployment of sexuality. Such a concern about the incestuous nature of family relations, in turn, forced theologians to consider the problem of incest in the postlapsarian origins of society.

As interventional procedures have become progressively more sophisticated and lengthy, the potential for high patient radiation dose has increased. Staff exposure arises from patient scatter, so steps to minimize patient dose will in turn reduce operator and staff dose. The practice of ALARA in an interventional radiology (IR) suite, therefore, requires careful attention to technical detail in order to reduce patient dose. The choice of imaging modality should minimize radiation when and where possible. In this paper practical steps are outlined to reduce patient dose. Further details are included that specifically reduce operator exposure. Challenges unique to pediatric intervention are reviewed. Reference is made to experience from modern pediatric interventional suites. Given the potential for high exposures, the practice of ALARA is a team responsibility. Various measures are outlined for consideration when implementing a quality assurance (QA) program for an IR service.

Lyme disease is an infection caused by the bite of the deer tick. It is the most common vector-transmitted disease in the United States. Past treatment practices included the administration of oral and/or i.v. antibiotics. Today the question is "to treat or not to treat." The etiology, signs and symptoms, and current treatments and management of Lyme disease and its associated somatic complaints are discussed.

CPR courses (both basic and advanced) continue to evolve. The recent CPR and ECC guidelines by the AHA consolidate the research and vast experience in one document. These guidelines are helpful to lay people and health care professionals who intervene in cases of cardiac arrest. They are also excellent resources for those involved in coordinating ECC systems in the community.