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For over two decades now, the application of Citizen Science to Education has been evolving, and fundamental topics, such as the drivers of motivation to participate in Citizen Science projects, are still under discussion. Some recent developments, though, like the use of Artificial Intelligence to support data collection and validation, seem to point to a clear-cut divergence from the mainstream research path. The objective of this paper is to summarise the development trajectory of research on Citizen Science in Education so far, and then shed light on its future development, to help researchers direct their efforts towards the most promising open questions in this field. We achieved these objectives by using the lens of the Affordance-Actualisation theory and the Main Path Analysis method.

I present a new model of the self-regulation of virtue that integrates perspectives on emotion, cognition, and motivation. Across three vignette-based studies in US/UK (N = 1,540), I developed through exploratory and confirmatory factor analysis a multi-item measure of broadening and defensive responses, the Self-Regulation of Virtue Inventory (SRVI). I applied that measurement model to two new scenarios portraying prototypical moral exemplars (selected from a set of 12) and fitted structural models that identify key antecedents: motivational dispositions (regulatory focus and hedonic orientation) and moral comparisons (opinion- and ability-based). The findings were consistent with network analysis, providing initial evidence of their robustness. By integrating literatures on motivation, emotion, social cognition and comparison within a self-regulation framework, I provide initial evidence to advance theory on moral self-regulation and moral education, with practical implications on how to maximise the upsides of virtue while mitigating or channelling its possible drawbacks.

(1) Background: Physical activity is known to promote health and psychological well-being in older adults, yet global inactivity rates in this population remain high. Among the factors associated with physical activity, self-efficacy for exercise represents a key predictor for developing effective interventions in older adults. This study aimed to validate the Self-Efficacy for Exercise Scale (SEE) in individuals over 65. (2) Methods: A sample of 726 older adults from the USA and Italy (51.1% females; age range = 65–95 years; Mage = 72.57, SDage = 6.49) completed the SEE, along with the Godin–Shepard Leisure-Time Physical Activity Questionnaire (GSLTPAQ), the Big Five Inventory 2—Extra Short Form (BFI-2-XS), and the 12-item Short Form Health Survey (SF-12). (3) Results: The SEE showed a Cronbach's Alpha of 0.88 and a Composite Reliability of 0.89. Moreover, it demonstrated a unidimensional factor structure and good fit indices. Full measurement invariance was achieved across gender and age, while partial scalar invariance was found across countries, suggesting minor cultural differences. Correlation with the GSLTPAQ, the BFI-2-XS, and the SF-12 support the convergent and nomological validity of the SEE. (4) Conclusions: These findings provide evidence that the SEE is a reliable and valid measure of self-efficacy for exercise among older adults and that the items are interpreted similarly across different ages, genders, and cultures. [ABSTRACT FROM AUTHOR]

Background: Neighborhood poverty is associated with adiposity in women, though longitudinal designs, annually collected residential histories, objectively collected anthropometric measures, and geographically diverse samples of midlife women remain limited. Objective: To investigate whether longitudinal exposure to neighborhood concentrated poverty is associated with differences in body mass index (BMI) and waist circumference (WC) among 2,328 midlife women (age 42–52 years at baseline) from 6 U.S. cities enrolled in the Study of Women's Health Across the Nation (SWAN) from 1996 to 2007. Methods: Residential addresses and adiposity measures were collected at approximately annual intervals from the baseline visit through a 10-year follow-up. We used census poverty data and local spatial statistics to identify hot-spots of high concentrated poverty areas and cold-spots of low concentrated poverty located within each SWAN site region, and used linear mixed-effect models to estimate percentage differences (95% confidence interval [CI]) in average BMI and WC levels between neighborhood concentrated poverty categories. Results: After adjusting for individual-level sociodemographics, health-related factors, and residential mobility, compared to residents of moderate concentrated poverty communities, women living in site-specific hot-spots of high concentrated poverty had 1.5% higher (95% CI: 0.6, 2.3) BMI and 1.3% higher (95% CI: 0.5, 2.0) WC levels, whereas women living in cold-spots of low concentrated poverty had 0.7% lower (95% CI: −1.2, −0.1) BMI and 0.3% lower (95% CI: −0.8, 0.2) WC. Site-stratified results remained in largely similar directions to overall estimates, despite wide CIs and small sample sizes. Conclusions: Longitudinal exposure to neighborhood concentrated poverty is associated with slightly higher BMI and WC among women across midlife. [ABSTRACT FROM AUTHOR]

Background Vasospasm and delayed cerebral ischemia (DCI) are the leading causes of morbidity and mortality after intracranial aneurysmal subarachnoid hemorrhage (aSAH). Vasospasm detection, prevention and management, especially endovascular management varies from center to center and lacks standardization. We aimed to evaluate this variability via an international survey of how neurointerventionalists approach vasospasm diagnosis and endovascular management. Methods We designed an anonymous online survey with 100 questions to evaluate practice patterns between December 2021 and September 2022. We contacted endovascular neurosurgeons, neuroradiologists and neurologists via email and via two professional societies -- the Society of NeuroInterventional Surgery (SNIS) and the European Society of Minimally Invasive Neurological Therapy (ESMINT). We recorded the physicians' responses to the survey questions. Results A total of 201 physicians (25% [50/201] USA and 75% non-USA) completed the survey over 10 months, 42% had >7 years of experience, 92% were male, median age was 40 (IQR 35-46). Both high-volume and low- volume centers were represented. Daily transcranial Doppler was the most common screening method (75%) for vasospasm. In cases of symptomatic vasospasm despite optimal medical management, endovascular treatment was directly considered by 58% of physicians. The most common reason to initiate endovascular treatment was clinical deficits associated with proven vasospasm/DCI in 89%. The choice of endovascular treatment and its efficacy was highly variable. Nimodipine was the most common first- line intra-arterial therapy (40%). Mechanical angioplasty was considered the most effective endovascular treatment by 65% of neurointerventionalists. Conclusion Our study highlights the considerable heterogeneity among the neurointerventional community regarding vasospasm diagnosis and endovascular management. Randomized trials and guidelines are needed to improve standard of care, determine optimal management approaches and track outcomes. [ABSTRACT FROM AUTHOR]

Background The number of patients with skin and soft tissue infections (SSTIs) in the United States appeared to be increasing well into the 21st century. However, no recent data have confirmed this trend. Methods This retrospective, observational cohort study used claims data over 11 years (2010–2020) from Optum's de-identified Clinformatics Data Mart Database. SSTI episodes, complications, and comorbidities were identified using International Classification of Diseases codes. Annual SSTI incidence rates, proportions of recurrent SSTI, SSTI-associated deaths, and total costs were estimated. Results During the study period, 5.4 million patients experienced 9.1 million SSTI episodes, with an incidence of 77.5 (95% confidence interval, 77.4–77.5) per 1000 person-years of observation (PYO). Annual incidence did not change significantly over time. Overall incidence (per 1000 PYO) of SSTI episodes in patients without comorbidities was 32.1 (highest incidence was for previous SSTI [113.5]) versus much higher rates if comorbidities were present. Incidence rates (per 1000 PYO) of chronic ulcers increased over time from 11.3 to 18.2 (P <.0001) and complicated disease from 3.5 to 6.3 (P <.0001). Deaths occurring within 30 days post–SSTI hospitalization rose from 2.6% to 4.6% in 2020. Recurrences occurred in 26.3% of index cases. The mean cost of an SSTI episode was US$3334 (median US$190) and was highest for surgical site infections and chronic ulcers. Conclusions The epidemiology of SSTI in the United States is changing and the disease burden is increasing despite stabilization in overall incidence. These data can inform identification of priority populations who could benefit from targeted interventions. [ABSTRACT FROM AUTHOR]

The classification of river catchments into groups with similar biophysical characteristics is useful to understand and predict their hydrological behavior. The increasing availability of remote sensing and other large-scale geospatial datasets has enabled the use of advanced data-driven approaches to classify catchments using traits such as topography, geology, climate, land cover, land use, and human influence. Unsupervised clustering algorithms based on the Euclidean distance are commonly used for trait-based classification but are not suitable for highly dimensional data. In this study we present a new network-based method for multi-scale catchment classification, which can be applied to large datasets and used to determine the traits associated with different catchment groups. In this framework, two networks are analyzed in parallel: the first being where the nodes are traits and the second being where the nodes are catchments. In both cases, edges represent pairwise similarity, and a network cluster detection algorithm is used for the classification. The trait network is used to investigate redundancy in the trait data and to condense this information into a small number of interpretable categories. The catchments network is used to classify the catchments into clusters and to identify representative catchments for the different groups using the degree centrality metric. We apply this method to classify 9067 river catchments across the contiguous United States at both regional and continental scales using 274 non-categorical traits. At the continental scale, we identify 25 interpretable trait categories and 34 catchment clusters of sizes greater than 50. We find that catchments with similar trait categories are typically located in the same region, with different spatial patterns emerging among clusters dominated by natural and anthropogenic traits. We also find that the catchment clusters exhibit distinct hydrological behavior based on an analysis of streamflow indices. This network approach provides several advantages over traditional means of classification, including better separation of clusters, the use of alternate similarity metrics that are more suitable for highly dimensional data, and reducing redundancy in the trait information. The paired catchment–trait networks enable analysis of hydrological behavior using the dominant trait categories for each catchment cluster. The approach can be used at multiple spatial scales since the network topologies adjust automatically to reflect the trait patterns at the scale of investigation. Finally, the representative catchments identified as hub nodes in the network can be used to guide transferable observational and modeling strategies. The method is broadly applicable beyond hydrology for classification of other complex systems that utilize different types of trait datasets. [ABSTRACT FROM AUTHOR]

PURPOSE: We investigated the association of financial toxicity (FT) with the health-related quality of life (HRQoL) profile of patients with hematologic malignancies treated in a universal health care system. METHODS: We did a secondary analysis of six multicenter studies enrolling patients with hematologic malignancies. FT was evaluated using the financial difficulties item of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). Multivariable linear regression models were used to assess the mean differences in HRQoL scores between patients with or without FT, while adjusting for key potential confounding factors. We also examined the prevalence of clinically important problems and symptoms by the experience of FT, using established thresholds for the EORTC QLQ-C30. Multivariable binary logistic regression analysis was performed to explore the risk factors associated with FT. RESULTS: Overall, 1,847 patients were analyzed, of whom 441 (23.9%) reported FT. We observed statistically and clinically relevant worse scores for patients with FT compared with those without FT for all the EORTC QLQ-C30 scales. The three largest clinically relevant mean differences between patients with and without FT were observed in pain (∆ = 19.6 [95% CI, 15.7 to 23.5]; P <.001), social functioning (∆ = –18.9 [95% CI, –22.5 to –15.2]; P <.001), and role functioning (Δ = –17.7 [95% CI, –22.1 to –13.3]; P <.001). Patients with FT tended to report a higher prevalence of clinically important problems and symptoms across all EORTC QLQ-C30 scales. In the univariable and multivariable analyses, the presence of FT was associated with the presence of comorbidities, an Eastern Cooperative Oncology Group performance status ≥1, and not receiving a salary. CONCLUSION: Patients with hematologic malignancies treated in the setting of a universal health care system who experience FT have a worse HRQoL profile compared with those without FT. [ABSTRACT FROM AUTHOR]

The article suggests the effectiveness of incorporating digital video projects into retelling of local historical narratives to facilitate student learning of history in the U.S. Topics include the importance of considering the local history of a certain narrative before constructing a comprehensive retelling of any particular national history, and a background on the development of the Satchel & the Yastrzemskis digital video project to retell America's black baseball history.

Adoption of Maker programs entails deep cultural and structural changes within schools. In this case study, we interviewed a principal and seven faculty members in a high school in the United States, after the first year of implementing making-centered curricula. We report how faculty members responded to the reform, their motivations and beliefs, and the concomitant shifts in power and status. We found that educators are required to make non-trivial adaptations to their skills, instructional approaches, and pedagogical beliefs, and that successful adaptation may lead them to gain status, resources, and support within the school. Those are gained on account of technical expertise and educators' efforts to promote the vision of the reform. The extent to which faculty members adapt to a reform, accommodate and support others in their process of adapting, or resist it, may determine whether the reform is successful or not. As such, school leaders face the challenge of encouraging faculty to buy into such reforms. The case study provides a unique perspective on Maker-centered reforms and outlines important implications for administrators seeking to implement similar programs. [ABSTRACT FROM AUTHOR]

Aim: We propose a combined approach to explore the model transferability and the effect of climate change on habitat suitability. Location: Southwest United States. Taxon: Amphibians; Anura; Bufonidae; Anaxyrus microscaphus. Methods: To assess the impacts of climate change on A. microscaphus, we obtained 3162 records from the Arizona Game and Fish Department. We classified occurrence records data into six historical groups (from 1960 to 2018) and a contemporary group (from 2019 to 2022). We investigated the ability of historical data to generate accurate predictions of the species' contemporary distribution. We used species distribution modelling to compute habitat suitability values and identified spatial clusters of high suitability values (using hotspot analyses). Results: We show that historical occurrences successfully predicted the contemporary distribution of A. microscaphus. We demonstrate that the geographical distribution of contemporary hotspots is strongly related to precipitation of the wettest quarter. This research provides evidence that climate change will likely affect the distribution of hotspots and the habitat suitability of A. microscaphus. Losses of 37%–48% contraction are expected at the margins of the range both in the north and south of the geographic limits. Main Conclusions: We show that recent past data can be used to predict contemporary species distribution accurately. We highlight that habitat suitability values of A. microscaphus are strongly related to climate, topography and distance to streams. This study provides clear evidence of the negative impacts of climate change on habitat suitability in the Southwest United States drylands. Our approach has applied utility to managers to target survey areas, monitor habitat changes, plan for conservation mitigation measures, conserve stream flows across the species' range and inform recovery if needed. Thus, managers could use previously collected data to predict contemporary species distribution when their occurrence accurately characterizes the species' ecological niche. [ABSTRACT FROM AUTHOR]

Based on a survey of 4,393 journalism students in Australia, Brazil, Chile, Mexico, South Africa, Spain, Switzerland, and the United States, this study provides much-needed comparative evidence about students' motivations for becoming journalists, their future job plans, and expectations. Findings show not only an almost universal decline in students' desire to work in journalism by the end of their program but also important national differences in terms of the journalistic fields in which they want to work, as well as their job expectations. The results reinforce the need to take into account national contexts when examining journalism education across the globe.

Objective: Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) and EULAR have developed the first‐ever validated classification criteria for symptomatic CPPD disease. Methods: Supported by the ACR and EULAR, a multinational group of investigators followed established methodology to develop these disease classification criteria. The group generated lists of candidate items and refined their definitions, collected de‐identified patient profiles, evaluated strengths of associations between candidate items and CPPD disease, developed a classification criteria framework, and used multi‐criterion decision analysis to define criteria weights and a classification threshold score. The criteria were validated in an independent cohort. Results: Among patients with joint pain, swelling, or tenderness (entry criterion) whose symptoms are not fully explained by an alternative disease (exclusion criterion), the presence of crowned dens syndrome or calcium pyrophosphate crystals in synovial fluid are sufficient to classify a patient as having CPPD disease. In the absence of these findings, a score >56 points using weighted criteria, comprising clinical features, associated metabolic disorders, and results of laboratory and imaging investigations, can be used to classify as CPPD disease. These criteria had a sensitivity of 92.2% and specificity of 87.9% in the derivation cohort (190 CPPD cases, 148 mimickers), whereas sensitivity was 99.2% and specificity was 92.5% in the validation cohort (251 CPPD cases, 162 mimickers). Conclusion: The 2023 ACR/EULAR CPPD disease classification criteria have excellent performance characteristics and will facilitate research in this field. [ABSTRACT FROM AUTHOR]

Simple Summary: This study reports the clinical outcome of 704 papillary thyroid cancer (PTC) patients followed at our institution for a median time of 8 years. Currently, the long-term follow-up is based on the response to initial therapy (excellent response, indeterminate response, or biochemical or structural incomplete response) evaluated at 6–12 months after initial treatment. We assumed that the long-term follow-up of PTC patients might be better tailored by integrating the response to initial therapy with the American Thyroid Association (ATA) risk stratification system (low-, intermediate- and high-risk). This study confirmed that the initial response to therapy is predictive of the long-term outcome in PTC patients but also showed that the initial ATA risk class may be useful for improving the risk-adapted management of PTC patients based on the response to initial therapy. Background: In recent years, there has been a renewed interest in thyroid cancer management paradigms that use individualized risk assessments as the basis for treatment and follow-up recommendations. In this study, we assumed that the long-term follow-up of differentiated thyroid cancer patients might be better tailored by integrating the response to initial therapy with the America Thyroid Association (ATA) risk classes. Methods: This retrospective study included low- and intermediate-risk papillary thyroid cancer (PTC) patients followed up for a median time of 8 years and classified according to the response to initial therapy assessed 6–12 months after initial treatment. Results: After a median follow-up of 8 years, in the initial excellent response subgroup of PTC patients (n = 522), the rate of recurrent disease was significantly higher in intermediate-risk patients than in low-risk PTC patients (6.9% versus 1.2%, p = 0.0005). Similarly, in the initial biochemical incomplete response subgroup (n = 82), the rate of excellent response was significantly higher in low-risk PTC patients (58.0%) than in intermediate-risk PTC patients (33.3%) (p = 0.007). Finally, in the initial structural incomplete response subgroup (n = 66), the rate of excellent response was higher in low-risk patients (80.0%) than in intermediate-risk patients (46.4%) (p = 0.08). Moreover, all patients with initial indeterminate response had an excellent response at the last follow-up visit. ATA risk classes were independently associated with long-term outcome in each subgroup of patients classified dynamically after initial therapy and the overall prognostic performance, defined via ROC curve analysis, of response to initial therapy integrated with the ATA risk system (AUC: 0.89; 95% CI: 0.86–0.92) was significantly higher compared to the ATA risk stratification (AUC 0.69; 95% CI: 0.65–0.74, p < 0.001) or the dynamic risk stratification (DRS) systems alone (AUC: 0.86 95% CI: 0.82–0.90, p = 0.007). Conclusions: This study of a large cohort of PTC patients showed that the initial ATA risk criteria may be useful for improving the risk-adapted management of PTC patients based on the response to initial therapy. [ABSTRACT FROM AUTHOR]

The classification of river catchments into groups with similar characteristics addresses the challenges posed by each location's unique properties to better understand and predict hydrological behaviors. The recent increasing availability of remote sensing and other large-scale geospatial datasets have enabled the use of advanced data-driven approaches to classify catchments using traits such as topography, geology, climate, land cover, land use, and human influence. Unsupervised clustering algorithms based on the Euclidean distance are commonly used for trait-based classification, but are subject to degradation when applied to high dimensional data. In this study we present a new network-based method for multi-scale catchment classification, which can be applied to large datasets and used to determine the traits associated with different catchment groups. In this framework two networks are analyzed in parallel; the first where the nodes are traits, and the second where the nodes are catchments. In both cases edges represent pairwise similarity and a network cluster detection algorithm is used for the classification. The traits network is used to investigate redundancy in the trait data and to condense this information into a small number of interpretable categories. The catchments network is used to classify the catchments into clusters, and to identify representative catchments for the different groups using the degree centrality metric. We apply this method to classify 9067 river catchments across the contiguous United States at both regional and continental scales using 274 non-categorical traits. At the continental scale we identify 25 interpretable categories of traits (e.g., developed areas, temperature, croplands) and 34 catchment clusters of size greater than 50. We find that catchments with similar trait categories are geographically coherent, with different spatial patterns emerging among the clusters that are dominated by natural and anthropogenic traits. We also find that the catchment clusters exhibit distinct hydrological behavior based on an analysis of streamflow indices. This network approach provides several advantages over traditional means of classification including the use of alternate similarity metrics that are more suitable for high dimensional data and providing interpretability with trait categories that reduce redundancies in the trait information. The paired catchment-trait networks enables analysis of hydrological behavior using the dominant trait categories for each catchment cluster. The approach can be used at multiple spatial scales, since the network topologies adjust automatically to reflect the trait patterns at the scale of investigation. Finally, the representative catchments identified as hub nodes in the network can be used to guide transferable observational and modeling strategies. The method is broadly applicable beyond hydrology for classification of other complex systems that utilize different types of trait datasets. [ABSTRACT FROM AUTHOR]

Youth with intellectual disabilities (IDs) demonstrate below-criteria motor competence (MC) compared with typically developing (TD) youth. Whether differences in MC exist for youth with ID from different countries is unknown. This study examined the MC of youth with ID from Brazil (BR) and the United States (US) and compared it with norms for TD youth as established by the Bruininks–Oseretsky Test of Motor Proficiency (BOT-2). The authors measured 19 BOT-2 test items for bilateral coordination, balance, and upper limb coordination of 502 youth (BR = 252, US = 250) with ID (6–21 years). Raw scores were converted to %ceiling (percentile of highest expected scores). For all test items, no significant differences were seen between BR and US participants in %ceiling scores. Participants from both countries demonstrated equivalent to slightly below BOT-2 norms in 14 of the 19 test items, with lowest scores seen in contralateral synchronizing bilateral coordination, balancing on one leg, and ball handling. [ABSTRACT FROM AUTHOR]

Aims and objectives: This study examined the occurrence rate of specific types of premature ventricular complex (PVC) alarms and whether patient demographic and/or clinical characteristics were associated with PVC occurrences. Background: Because PVCs can signal myocardial irritability, in‐hospital electrocardiographic (ECG) monitors are typically configured to alert nurses when they occur. However, PVC alarms are common and can contribute to alarm fatigue. A better understanding of occurrences of PVCs could help guide alarm management strategies. Design: A secondary quantitative analysis from an alarm study. Methods: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist was followed. Seven PVC alarm types (vendor‐specific) were described, and included isolated, couplet, bigeminy, trigeminy, run PVC (i.e. VT >2), R‐on‐T and PVCs/min. Negative binomial and hurdle regression analyses were computed to examine the association of patient demographic and clinical characteristics with each PVC type. Results: A total of 797,072 PVC alarms (45,271 monitoring hours) occurred in 446 patients, including six who had disproportionately high PVC alarm counts (40% of the total alarms). Isolated PVCs were the most frequent type (81.13%) while R‐on‐T were the least common (0.29%). Significant predictors associated with higher alarms rates: older age (isolated PVCs, bigeminy and couplets); male sex and presence of PVCs on the 12‐lead ECG (isolated PVCs). Hyperkalaemia at ICU admission was associated with a lower R‐on‐T type PVCs. Conclusions: Only a few distinct demographic and clinical characteristics were associated with the occurrence rate of PVC alarms. Further research is warranted to examine whether PVCs were associated with adverse outcomes, which could guide alarm management strategies to reduce unnecessary PVC alarms. Relevance to clinical practice: Targeted alarm strategies, such as turning off certain PVC‐type alarms and evaluating alarm trends in the first 24 h of admission in select patients, might add to the current practice of alarm management. [ABSTRACT FROM AUTHOR]

Background: Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular events, including acute coronary syndrome (ACS). There is conflicting evidence that suggests OSA has a cardioprotective effect (ie, lower troponin), via ischemic preconditioning, in patients with ACS. Purpose: This study had 2 aims: (1) compare peak troponin between non–ST elevation (NSTE) ACS patients with and without moderate OSA identified using a Holter-derived respiratory disturbance index (HDRDI) and (2) determine the frequency of transient myocardial ischemia (TMI) between NSTE-ACS patients with and without moderate HDRDI. Method: This was a secondary analysis. Obstructive sleep apnea events were identified from 12-lead electrocardiogram Holter recordings using QRSs, R-R intervals, and the myogram. Moderate OSA was defined as an HDRDI of greater than or equal to 15 events per hour. Transient myocardial ischemia was defined as greater than or equal to 1 mm of ST-segment ↑ or ↓, in 1 or more electrocardiogram lead, lasting at least 1 minute. Results: In 110 patients with NSTE-ACS, 39% (n = 43) had moderate HDRDI. Peak troponin was lower in patients with moderate HDRDI (6.8 ng/mL yes vs 10.2 ng/mL no; P =.037). There was a trend for fewer TMI events, but there were no differences (16% yes vs 30% no; P =.081). Conclusions: Non–ST elevation ACS patients with moderate HDRDI have less cardiac injury than those without moderate HDRDI measured using a novel electrocardiogram-derived method. These findings corroborate previous studies suggesting a possible cardioprotective effect of OSA in patients with ACS via ischemic precondition. There was a trend for fewer TMI events in patients with moderate HDRDI, but there was no statistical difference. Future research should explore the underlying physiologic mechanisms of this finding. [ABSTRACT FROM AUTHOR]

The following contribution analyzes the controversies surrounding the so-called cancel culture, which arose within the "culture wars" in the United States. These wars pit ultraconservative and anti-liberal movements, which support religious fundamentalism, xenophobia, and extreme nationalism, against movements that fight for social justice and minority rights. Cancel culture is part of this struggle and involves the practice of canceling, revising, or inventing aspects of the past to support dominant views in the present. This struggle is based on identity politics, interpreting social justice based on belonging to specific social groups, such as race, gender, and sexual orientation, often ignoring social class. The "third wave" of social justice movements develops in a context where equal rights are widely recognized, and anti-racism and inequality ideologies are hegemonic. This has transformed the nature and strategies of the movements, which now focus on symbolic and communicative actions, fueling political correctness in a more invasive way. The most wellknown cases of cancel culture also fuel conservative propaganda and provide them with the opportunity to present themselves as defenders of free speech. From the perspective of social sciences and anthropology, the phenomenon of cancel culture raises two aspects of interest: the first concerns the influence of activism on social theory and research methodology, which can lead to ideological caricatures; the second concerns the creation of an atmosphere of suspicion, accusations, and confessions in public spheres, which connects to the Puritan roots of Anglo-American culture. [ABSTRACT FROM AUTHOR]

This article explores the historical legacy of the U.S. –Colombia binational strategy known as Plan Colombia, its impact on the structure of Colombia‘s military forces and the decrease in cocaine production in the period 1999-2012 through an analysis of the successes and failures of the strategies employed and the political, social, economic and military context of the time. By employing a case study methodology, the article identifies the reasons for the increase of state capacity in the defense sector, the weakening and dismantling of the structures of illegal organizations and the significant reduction of coca crops, thus providing theoretical inputs for the structuring, design and implementation of future strategies to manage complex security and defense issues. [ABSTRACT FROM AUTHOR]

The technical advancements made in DNA profiling now allow for very low DNA amounts to be analyzed. Accordingly, the argument often made in criminal courts is not who the DNA belongs to but rather how it was deposited. Despite the complexity of the relevant DNA transfer, persistence, prevalence, and recovery issues, forensic laboratories in some European countries have used evaluative reports with activity level propositions, while this is not current practice in the United States. The purpose of this study was to gain an overview of the opinions about activity level reporting (ALR) held by forensic biologists in the United States. A seventeen‐question survey was distributed to members of the American Society of Crime Laboratory Directors and U.S. members of the International Society for Forensic Genetics. The survey included multiple‐choice and open‐response questions and received 54 responses. The majority of responses expressed moderate support of ALR. Participants mentioned six major concerns to be addressed prior to implementing ALR in the United States: (1) effect of number of variables involved; (2) need of education for practitioners/legal system; (3) inadequate number of activity studies with realistic scenarios; (4) difficulty of achieving admissibility in court; (5) need for standardized approaches/guidelines; and (6) requisite shift in perspective as to the validity of ALR. Overall, this small segment of U.S. forensic DNA practitioners appear to be willing to implement ALR once these concerns are fully addressed and resolved. As a follow‐up, it would be worthwhile exploring these and other questions with a larger group and also other disciplines. [ABSTRACT FROM AUTHOR]

Background: Insertable cardiac monitors (ICMs) are essential for ambulatory arrhythmia diagnosis. However, definitive diagnoses still require time‐consuming, manual adjudication of electrograms (EGMs). Objective: To evaluate the clinical impact of selecting only key EGMs for review. Methods: Retrospective analyses of randomly selected Abbott Confirm Rx™ devices with ≥90 days of remote transmission history were performed, with each EGM adjudicated as true or false positive (TP, FP). For each device, up to 3 "key EGMs" per arrhythmia type per day were prioritized for review based on ventricular rate and episode duration. The reduction in EGMs and TP days (patient‐days with at least one TP EGM), and any diagnostic delay (from the first TP), were calculated versus reviewing all EGMs. Results: In 1000 ICMs over a median duration of 8.1 months, at least one atrial fibrillation (AF), tachycardia, bradycardia, or pause EGM was transmitted by 424, 343, 190, and 325 devices, respectively, with a total of 95 716 EGMs. Approximately 90% of episodes were contributed by 25% of patients. Key EGM selection reduced EGM review burden by 43%, 66%, 77%, and 50% (55% overall), while reducing TP days by 0.8%, 2.1%, 0.2%, and 0.0%, respectively. Despite reviewing fewer EGMs, 99% of devices with a TP EGM were ultimately diagnosed on the same day versus reviewing all EGMs. Conclusion: Key EGM selection reduced the EGM review substantially with no delay‐to‐diagnosis in 99% of patients exhibiting true arrhythmias. Implementing these rules in the Abbott patient care network may accelerate clinical workflow without compromising diagnostic timelines. [ABSTRACT FROM AUTHOR]

To characterize inpatient rehabilitation services for children with severe traumatic brain injury (TBI), we included 254 children, whose parents/guardians reported receipt of rehabilitation within a 12-month follow-up period, from a multinational observational study. Children discharged to an inpatient rehabilitation or skilled nursing facility after acute care were classified into the "inpatient rehabilitation" group, and children discharged home after acute care were classified into the "non-inpatient rehabilitation" group. Multivariable regression analyses determined the associations of sociodemographic and clinical characteristics with rehabilitation groups. Children receiving inpatient rehabilitation had a shorter length of acute hospitalization. Children from the UK were less likely to receive inpatient rehabilitation compared to children from the US. Future studies are warranted to extend current findings by identifying the reasons behind differential access to inpatient rehabilitation among children with severe TBI. [ABSTRACT FROM AUTHOR]

This paper compares labor market flows between a developing economy, Colombia, and a developed one, the United States (US). In a comparative framework, we explore measures of labor market flows across dimensions such as firm size, age, and economic sector. This comparison allows us testing, for both countries, a series of interesting hypothesis suggested in the literature, namely the negative systematic relationship between firm size/age and employment growth rate. We find that labor market fluidity in the US labor market is substantially higher than in Colombia and that the churning rate is twice as high for the US market as it is for the Colombian one. We argue that this fluidity gap between the two economies can be explained by, among other factors, the rigid nature of Colombian labour market institutions. [ABSTRACT FROM AUTHOR]

Background Staphylococcus aureus skin and soft tissue infections (SA-SSTIs) are common in healthcare and community settings, and recurrences occur at variable frequency, even after successful initial treatment. Knowing the exact burden and timing of recurrent disease is critical to planning and evaluating interventions to prevent recurrent SSTIs. Methods In this retrospective study, SSTI cases in patients aged ≥18 years at 3 US medical centers (Columbia, Chicago, Vanderbilt) between 2006 and 2016 were analyzed according to a biennial cohort design. Index SSTIs (with or without key comorbidities), either microbiologically confirmed to be SA-SSTI or not microbiologically tested (NMT-SSTI), were recorded within 1 calendar year and followed up for 12 months for recurrent infections. The number of index cases, proportion of index cases with ≥1 recurrence(s), time to first recurrence, and number of recurrences were collected for both SA-SSTI and NMT-SSTI events. Results In the most recent cohorts, 4755 SSTI cases were reported at Columbia, 2873 at Chicago, and 6433 at Vanderbilt. Of these, 452, 153, and 354 cases were confirmed to be due to S. aureus. Most cases were reported in patients without key comorbidities. Across centers, 16.4%–19.0% (SA-SSTI) and 11.0%–19.2% (NMT-SSTI) of index cases had ≥1 recurrence(s). In patients without key comorbidities, more than 60% of index SSTIs with recurrences had only 1 recurrence, half of which occurred in the first 3 months following primary infection. Conclusions SA-SSTI recurrences are common among healthy adults and occur in at least 1 in 6 individuals during the 1 year following the primary event. [ABSTRACT FROM AUTHOR]

This study aims to present the profile of scientific production on the use of religiosity/spirituality in coping with childhood cancer. It is an integrative review in the bases/libraries Cumulative Index to Nursing and Allied Health Literature (CINAHL), Psychology Information (PsycINFO), Pubmed, Scientific Electronic Library Online (SciELO), and Latin America and the Caribbean Literature on Health Sciences (LILACS) (2009–2019). The guiding question was "How is religiosity/spirituality present in the treatment experiences of children and adolescents with cancer?" By the inclusion/exclusion criteria, 31 studies were retrieved. Most studies are from the United States; 2015 was the greatest publication year, and the participants in these surveys were children, adolescents, family members, and health professionals. Most studies did not specify what the participants' belief was. Interviews were the most used collection instruments, and the hospital environment was the main place for recruiting the subjects. The data found provide significant information for understanding the profile of scientific production related to the investigation of religiosity/spirituality in the experiences of cancer by children and adolescents and point out possible paths for future investigations in the area. [ABSTRACT FROM AUTHOR]

Beer remains the greatest source of per capita alcohol consumption in the United States, and increasing market availability and consumer demand for higher alcohol has meaningful public health consequences. Objectives: To determine whether apparent alcohol intake from beer changed among households over time, we used nationally-representative US Nielsen Consumer Panel purchasing data from 2004 to 2014, and incorporated information on percent alcohol by volume (ABV) to compute the number of standard drinks of alcohol consumed from beer as a result. Methods: We queried external data sources (e.g. official manufacture, consumer beer-related websites) to obtain beer-specific ABVs, merged this information with Nielsen consumer-level data, and calculated the average rate of beer and standard drink consumption per household per year. We used joinpoint regression to estimate annual percentage changes and annual absolute changes in intake over time, with separate piecewise linear segments fit between years if a significant deviation in trend was detected. Results: Higher alcohol content beer consumption increased steadily across the decade, accounting for 9.6% of total intake in 2004 compared to 21.6% of total intake by 2014. Standard drink intake from beer declined sharply post-2011 by 3.04% annually (95% CI: −5.93, −0.06) or by 4.52 standard drinks (95% CI: −8.69, −0.35) yearly – coinciding with several beer industry transitions, market share fluctuations, and consumer preference changes for beer occurring around that time. Conclusions: Despite consistent increases in higher alcohol content beer intake across the decade, households do not appear to be consuming more standard drinks of alcohol from beer as a result. Supplemental data for this article is available online at https://doi.org/10.1080/10826084.2021.1928208. [ABSTRACT FROM AUTHOR]

Introduction: A retained surgical sharp (RSS) is a never event and defined as a lost sharp (needle, blade, instrument, guidewire, metal fragment) that is not recovered prior to the patient leaving the operating room. A "near-miss" sharp (NMS) is an intraoperative event where there is a lost surgical sharp that is recovered prior to the patient leaving the operating room. With underreporting of such incidents, it is unrealistic to expect aggressive development of new prevention and detection strategies. Moreover, awareness about the issue of "near-miss" or retained surgical sharps remains limited. The aim of this large-scale national survey-based study was to estimate the incidence of these events and to identify the challenges surrounding the use of surgical sharps in daily practice. Methods: We hypothesized that there was a larger number of RSS and NMS events than what was being reported. We survived the different OR team members to determine if there would be discordance in reported incidence between groups and to also evaluate for user bias. An electronic survey was distributed to OR staff between December 2019 and April 2020. Respondents included those practicing within the United States from both private and academic institutions. Participants were initially obtained by designating three points of contact who identified participants at their respective academic institutions and while attending specialty specific medical conferences. Together, these efforts totaled 197 responses. To increase the number of respondents, additional emails were sent to online member registries. Approximately 2650 emails were sent resulting in an additional 250 responses (9.4% response rate). No follow up reminders were sent. In total, there were 447 survey responses, in which 411 were used for further analysis. Thirty-six responses were removed due to incomplete respondent data. Those who did not meet the definition of one of the three categories of respondents were also excluded. The 411 were then categorized by group to include 94 (22.9%) from anesthesiologist, 132 (32.1%) from resident/fellow/attending surgeon and 185 (45%) from surgical nurse and technologist. Survey: The survey was anonymous. Participants were asked to answer three demographic questions as well as eight questions related to their personal perception of NMS and RSS (Fig. 1). Demographic questions were asked with care to ensure no identifiable information was obtained and therefore unable to be traced back to a specific respondent or institution. Perception questions 4–6 and 11 were designed to understand the incidence of various sharp events (e.g. lost, retained, miscounted). Questions 7 and 10 were dedicated to understanding time spent managing sharps and questions 8 and 9 were dedicated to understanding the use x-ray and its effectiveness. Results: Overall, most of each respondent group reported 1–5 lost sharp events over the last year. Roughly 20% of surgeons believed they never had a miscounted sharp over the last year, where only 5.3% of anesthesiologist reported the same (p = 0.002). Each group agreed that roughly 4 lost events occur every 1000 surgeries, but a significant difference was found between the three groups regarding the number of lost sharps not recovered per 10,000 surgeries with anesthesiologist, surgeon and nurse/technologist groups estimating 2.37, 2.56 and 2.94 respectively (p = 0.001). All groups noted x-ray to offer poor effectiveness at 26–50% with 31-40 min added for each time x-ray was used. More than half (56.8%) of surgeons reported using x-ray 100% of the time when managing a lost sharp whereas anesthesiologists and nurses/technologists believe it is closer to 1/3 of the time. An average of 21-30 min is spent managing each NMS, making a lost sharp event result in up to 70 min of added OR time. Conclusions: "Near-miss" and RSS are more prevalent than what is reported in current literature. Surgeons perceive a higher rate of success in retrieving the RSS when compared to anesthesiologists and OR nurses/technologists. We recognize several challenges surrounding "near-miss" and never events as contributing factors to their underreported nature and the higher degree of surgeon recall bias associated with these events. Additionally, we highlight that current methods for prevention are costly in time and resources without improvement in patient safety. As NMS and RSS have significant health system implications, a strong understanding of these implications is important as we strive to improve patient safety. [ABSTRACT FROM AUTHOR]

Shrub willow (Salix spp. and hybrids) is a biomass crop well adapted to the northeastern United States. We assessed the biomass productivity of six willow cultivars in a 14.5-ha field in Pennsylvania through two rotation cycles of 3 yr each, comparing the realized and biophysical yield potential. We also evaluated the relationship of yield with plant density and the harvest efficiency. The realized yield of the best cultivars was about 8 Mg ha-1 yr-1, well below the calculated harvestable potential of 14 Mg ha-1 yr-1. Uniform stands of willow without planting gaps may maximize yield with 8 x 10³ plants ha-1, but upright cultivars may benefit from higher densities. Harvest is relatively slow at 1 ha h-1 or 20 Mg h-1 in the longest rows with optimal ground conditions, which makes the harvest cost per hour high. Biotic stresses built up gradually during the 7 yr of the experiment affecting two cultivars severely. The cultivar S. miyabeana x S. viminalis 'Preble' was defoliated by a growing population of willow leaf beetle (Plagiodera versicolora), whereas the cultivar S. purpurea 'Fish Creek' was affected by two fungal diseases and suffered a major stand loss in the winter of 2019/2020. Both examples justify breeding for insects and diseases resistance. The moderate harvestable yield and high harvest cost imply that in the northeastern United States, the viability of willow for bioenergy with carbon capture and storage as a tool to reduce CO2 emissions may depend on the provision and monetization of additional ecosystem services. [ABSTRACT FROM AUTHOR]

Objective of the study: Statistics shows a worrisome picture of challenges to be overcome by cybersecurity in the healthcare sector. Data evidence that the healthcare industry experiences four data breaches per week in the United States alone, making it the sector most often affected by digital security breaches. Thus, the current article aims to investigate risk management focusing on identifying requirements and best practices for healthcare data security systems. Methodology/approach: It is based on a systematic literature review. Studies on state-of-the-art data security systems were collected and interpreted through content analysis. Assertive keywords, sourceselection criteria, interpretation of selected articles, and database analysis were used to form the investigated sample and to represent the broad applications of this study's objective. Originality/Relevance: The current study contributes to define a set of minimum requirements and best practices that can be adopted to manage data security risks in the healthcare sector and medical devices. Main results: Results have pointed out that there is no fully effective way to prevent all violations by cybercriminals; however, cybersecurity must be part of management processes adopted by different organizations. Theoretical/methodological contributions: It is found that cybersecurity has a great importance for the healthcare sector, the information generated is rich in content and that cybersecurity is neglected in the sector, that is not able to deal with the reality of cyber threats in the industry 4.0 context. Social/management contributions: By the good risk management practices and the adoption of minimum security items, institutions can ensure that managers can prepare and respond efficiently to cyber risks. [ABSTRACT FROM AUTHOR]

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Background: Eyebrow and eyelash hair loss and nail damage—in addition to scalp hair loss—are important signs/symptoms of alopecia areata (AA) to patients and deserve assessment in AA clinical trials. Objectives: Our objective was to develop clinician-reported outcome (ClinRO) and patient-reported outcome (PRO) measures and accompanying photoguides to aid in the assessment of AA-related eyebrow, eyelash and nail signs/symptoms. Methods: Iterative rounds of qualitative, semi-structured interviews were conducted with US expert dermatologists and North American patients with AA. Patients with eyebrow, eyelash and nail involvement were purposefully sampled. Interview transcripts were qualitatively analyzed. Results: Dermatologists (n = 10) described eyebrow and eyelash loss as concerning for affected patients and, along with nail appearance, as deserving assessment. Dermatologist data informed the development of single item, 4-point Likert-type ClinRO and PRO measures of current eyebrow loss, eyelash loss and nail appearance and a PRO measure of eye irritation. Patients (n = 45, age 15–72 years) confirmed the importance and relevance of these signs/symptoms. Interim revision resulted in measures that were understood by and relevant to patients. Dermatologists (n = 5) and patients (n = 10, age 21–54 years) participated in the development of the eyebrow, eyelash and nail photoguides and confirmed that they included photos that appropriately represented different severity levels and were helpful to derive and standardize ratings across raters. Conclusions: The ClinRO and PRO measures for eyebrow, eyelash and nail appearance, with their accompanying photoguides and the PRO Measure for Eye Irritation provide clear and meaningful assessments of outcomes important to patients with AA. [ABSTRACT FROM AUTHOR]

Lower back pain is the fifth most common reason for visiting a physician in the United States. Degenerative disc disease, degenerative spondylolisthesis, arthritis, and facet arthrosis are leading causes for lumbar spinal stenosis. The previous gold standard involved open laminectomy combined with medial facetectomy and foraminotomy. The advent of minimally invasive surgery (MIS) and endoscopic technologies has led to less invasive and targeted interventions. In this study, the authors aim to show a five-year experience using a three-blade retractor for lumbar decompression and microdiscectomy. A database review of a single spine surgeon over the last 5 years with a total of 306 patients undergoing single-level lumbar decompression with and without microdiscectomy. The average age was 47 ± 12 years and the average BMI was 29.7 ± 5.7 kg/m2 with a total of 52% male patients. Operative levels included L3-4, L4-L5, and L5-S1, with 65% of procedures at the L5-S1 level and follow-up was for two years. Overall mean VAS back scores decreased from 7.9 ± 1.6 to 2.5 ± 1.1 at two-year follow-up, p = 0.001. Preoperative ODI scores improved from 32.1 ± 5.1 to 17.9 ± 4.3 at two-year follow-up, p = 0.002. The mean EBL and surgeon time was 21 ± 15 ml and 35 ± 17 min, respectively. This less exposure surgery technique can be performed to allow lumbar decompression, with or without microdiscectomy. This is an anatomy preserving technique with improved outcomes. [ABSTRACT FROM AUTHOR]

Financial sanctions and trade control regulations are becoming increasingly relevant in the current global situation, characterized by multiple ongoing conflicts, sophisticated terrorist organizations, and serious tensions between international economic actors. The United Nations, under Article 41 of the UN Charter, the United States and Europe, in particular, regularly introduce and enforce a number of tools (e. g., financial restrictions, trade restrictions, arms embargoes, travel bans). Such tools can range from comprehensive, "territory-wide" sanctions against States to targeted sanctions on entities, including individuals, to obtain a change in policy or activity by the target country, part of the country, governments, entities, and individuals, with the ultimate aim of pursuing peace, human rights, democracy, and respect for the rule of law. Recent history proves that companies and financial institutions have adopted complex solutions to conceal transactions with sanctioned countries and entities. Blockchain technology, through the use of distributed digitalized ledgers, grants a high level of transparency, for instance providing real-time updates on the development of an export transaction, and the use of smart contracts can automatize payments, or the triggering of guarantees, etc. While blockchain technology continues to be an area of enormous promise, it is also one of risk, if not managed properly, especially in a transnational, multi-jurisdictional context. Not only might the use of blockchain-based solutions prove challenging for the enforcement of current international sanctions programs by competent authorities, but blockchain technologies developers will also need to set up solutions suitable to comply with the requirements imposed by the various sanctions in place. At the same time, businesses will need to determine which measures and due diligence practices are needed to protect against the risks of a sanctions violation, which can result in significant fines and even criminal penalties. This paper explores how blockchain solutions that may be implemented in the context of international financial and commercial transactions can interrelate (or interfere) with sanctions enforcement and sanctions compliance, highlighting the multiple legal issues that may arise in connection thereto. [ABSTRACT FROM AUTHOR]

Ocular diseases are an important category in equine medicine; however, most articles regarding histologic ocular lesions in horses are exclusive to a specific condition and do not provide a complete review of clinically significant ocular disease frequency in a diagnostic laboratory. We reviewed sections of equine eyes from 140 cases (98 enucleations [biopsies] and 42 autopsies) with clinically relevant ocular alterations at 2 diagnostic centers in the United States. The most common primary conditions were non-traumatic keratitis (36), equine recurrent uveitis (ERU; 31), traumatic injuries (22), ocular and periocular neoplasms (19), and uveitis and/or endophthalmitis resulting from sepsis (18). Congenital anomalies (3) and retinal atrophy and detachment alone (3) were infrequent. Non-traumatic keratitis was frequently accompanied by anterior uveitis (22), corneal rupture (16), pre-iridal fibrovascular membrane formation (13), and secondary mycotic infection (11). ERU was the second and third most prevalent disease in autopsies and enucleations, respectively. This condition was commonly associated with glaucoma (15). Glaucoma (25) and cataract (20) were the most prevalent secondary alterations in the evaluated cases. Keratitis (20) and corneal rupture (16) were among the most prevalent consequences of trauma. Information presented herein may guide clinicians and pathologists, contributing to the early diagnosis of potentially vision-impairing conditions and raising the chances of successful treatment and cure. [ABSTRACT FROM AUTHOR]

We study the foreign externalities of the recent U.S. tax reform, commonly known as the Tax Cuts and Jobs Act (TCJA). Specifically, we examine foreign firms' stock returns around key tax reform events. We find significant heterogeneity in market responses by country, industry, and firm. Chinese firms experience large negative returns, especially in steel, business equipment, and chemical manufacturers, whereas the rest of the world experiences positive returns. Firms operating in more differentiated product markets experience positive returns, whereas firms in financial distress experience negative returns, consistent with the TCJA having competitive repercussions. We also find that firms experiencing decreases in effective tax rates following tax reform experience positive returns. Overall, our results suggest that the TCJA had varied, yet systematic effects on foreign firms' shareholders' wealth and the global competitive landscape. This paper was accepted by Brian Bushee, accounting. [ABSTRACT FROM AUTHOR]

Objective In older adults, the impact of persistent pain goes beyond simple discomfort, often contributing to worsening functional outcomes and ultimately frailty. Frailty is a geriatric syndrome that, like persistent pain, increases in prevalence with age and is characterized by a decreased ability to adapt to common stressors such as acute illness, thereby increasing risk for multiple adverse health outcomes. Evidence supports a relationship between persistent pain and both the incidence and progression of frailty, independent of health, social, and lifestyle confounders. Design and Setting In this article, we synthesize recent evidence linking persistent pain and frailty in an effort to clarify the nature of the relationship between these two commonly occurring geriatric syndromes. Setting We propose an integration of the frailty phenotype model by considering the impact of persistent pain on vulnerability toward external stressors, which can ultimately contribute to frailty in older adults. Results and Conclusions Incorporating persistent pain into the frailty construct can help us better understand frailty and ultimately improve care for patients with, as well as those at increased risk for, pain and frailty. [ABSTRACT FROM AUTHOR]

This article investigates the relationship between data breaches and identity theft, including the impact of Data Breach Notification Laws (DBNL) on these incidents (using empirical data and Bayesian modeling). We collected incident data on breaches and identity thefts over a 13-year timespan (2005–2017) in the United States. Our analysis shows that the correlation is driven by the size of a state. Enacting a DBNL still slightly reduces rates of identity theft; while publishing breaches notifications by Attorney Generals helps the broader security community learning about them. We conclude with an in-depth discussion on what the European Union can learn from the US experience. [ABSTRACT FROM AUTHOR]

We collect data from the 1979 National Longitudinal Survey of Youth and create comparable measures of monopsonistic power for up to 46 occupational labor markets in the USA, starting in 1979 and ending in 2000. Our results suggest most occupational labor markets during that period were characterized by substantial amounts of monopsonistic, wage-setting power. Furthermore, after controlling for individual, time, and industry fixed effects, our results show a negative and significant correlation between the extent of monopsony power that characterizes a market and both, the wages and fringe benefits received by workers. [ABSTRACT FROM AUTHOR]

Introducing a process model of power and institutional change, I argue that actors may seek power by creating, supporting, or modifying institutions. Lacking unilateral authority to enact new institutions, actors can leverage symbolic resources into coercive resources, which may require making concessions to multiple logics and stakeholders. The emergent organizations and institutions are then subject to adjustment to stakeholder and regulator expectations. The argument is illustrated in a case study of the 1968 Third World Strike at San Francisco State College, where the college president strove to increase his authority so he could prevail in a dispute with student activists. [ABSTRACT FROM AUTHOR]

Severe asthma in children remains a significant issue. It places a heavy burden on affected individuals and society as a whole in terms of high morbidity, mortality, consumption of healthcare resources, and side effects from high-dose corticosteroid therapy. New, targeted biologic therapies for asthma have emerged as effective add-on options, complementing our expanding understanding of asthma phenotypes/endotypes and the underlying immunopathology of the disease spectrum. They include omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab. Omalizumab represents the first available therapeutic option for allergic asthma in patients as young as 6 years of age. Its efficacy and safety have been established by several randomized controlled trials specifically conducted in pediatric patients, leading to its final registration > 10 years ago. Three new interleukin (IL)-5 targeted agents, mepolizumab, reslizumab, and benralizumab, have been approved for the treatment of severe eosinophilic asthma starting from 6 years of age, and varying by country. More recently, dupilumab, a targeted agent against the IL-4 receptor α-chain, was approved for patients ≥12 years of age in the United States after pivotal trials were completed. The late-stage clinical testing of these targeted agents has mostly involved patients aged 12 years and up, and the application of those data to younger children can be inappropriate and carry risk. The efficacy and safety of these newer biologics in children should be supported by adequate research within this targeted age group. In this review, we will present the most recent evidence on these five biological therapies for severe asthma and will discuss dosage and administration, their efficacy, safety, and future prospects, with a focus on the pediatric age group, defined as age < 18 years. [ABSTRACT FROM AUTHOR]

Introduction: Intrahepatic cholangiocarcinoma (ICC) remains an uncommon disease with a rising incidence worldwide. We sought to identify trends in therapeutic approaches and differences in patient outcomes based on facility types. Methods: Between January 1, 2004, and December 31, 2015, a total of 27,120 patients with histologic diagnosis of ICC were identified in the National Cancer Database and were enrolled in this study. Results: The incidence of ICC patients increased from 1194 in 2004 to 3821 in 2015 with an average annual increase of 4.16% (p < 0.001). Median survival of the cohort improved over the last 6 years of the study period (2004–2009: 8.05 months vs. 2010–2015: 9.49 months; p < 0.001). Among surgical patients (n = 5943, 21.9%), the incidence of R0 resection, lymphadenectomy and harvest of ≥6 lymph nodes increased over time (p < 0.001). Positive surgical margins (referent R0: R1, HR 1.49, 95% CI 1.24–1.79, p < 0.001) and treatment at community cancer centers (referent academic centers; HR 1.24, 95% CI 1.04–1.49, p = 0.023) were associated with a worse prognosis. Patients treated at academic centers had higher rates of R0 resection (72.4% vs. 67.7%; p = 0.006) and lymphadenectomy (55.6% vs. 49.5%, p = 0.009) versus community cancer centers. Overall survival was also better at academic versus community cancer programs (median OS: 11 months versus 6 months, respectively; p < 0.001). Conclusions: The incidence of ICC has increased over the last 12 years in the USA with a moderate improvement in survival over time. Treatment at academic cancer centers was associated with higher R0 resection and lymphadenectomy rates, as well as improved OS for patients with ICC. [ABSTRACT FROM AUTHOR]

This paper documents the speed of evolution (or lack thereof) of a range of values and beliefs of different generations of US immigrants, and interprets the evidence in the light of a model of socialization and identity choice. Convergence to the norm differs greatly across cultural attitudes. Moreover, results obtained studying higher generation immigrants differ from those found when the analysis is limited to the second generation and imply a lower degree of persistence than previously thought. Persistence is also country specific, in the sense that the country of origin of one's ancestors matters for the pattern of generational convergence. [ABSTRACT FROM AUTHOR]

Hypertension is one of the most common chronic diseases in adults and a leading cause of disability and mortality worldwide. Recently, new Guidelines for the diagnosis and management of hypertension have been released in Europe and in the United States, with changes regarding how to diagnose and treat the condition, and the extent to which intensive blood pressure control should be pursued. Important differences between the Guidelines exist in the classification of blood pressure levels and definition of treatment goals. Diagnosis of hypertension starts at 140/90 mmHg for the European Guidelines, and 130/80 mmHg for the US Guidelines. Besides, the European guidelines introduced the concept of "safety boundaries", consisting of BP thresholds not to be exceeded towards lower levels (120 mmHg for age < 65 years, 130 mmHg for older people) because of the fear of important adverse events associated with overtreatment. Such discrepancies can indeed have an impact on treatment attitudes and outcome incidence. Hence, we appraised facts in favor and against each of these controversial issues. In conclusion we believe that, instead of fixing rigid BP targets and boundaries, modern hypertension management should be aimed to achieve in each patient an optimal balance between intensive BP reduction and treatment safety. • New Guidelines have been recently released from Europe and North America. • Main differences: categorization of hypertension, BP targets, and safety boundaries. • The US Guidelines lowered the threshold for hypertension to 130/80 mmHg. • The US Guidelines recommend a systolic BP target<130 mmHg in almost all patients. • Safety boundaries may induce to refrain from achieving ambitious BP targets. [ABSTRACT FROM AUTHOR]

Objective: The most common complication after lumbar discectomy is reherniation. Although many studies have investigated factors that may increase the reherniation risk, few are agreed upon all. It has been suggested that limited nucleus removal is associated with higher reherniation risk, while more aggressive nucleus removal can result in increased disc degeneration. Here, we assessed the efficacy of a coblation-assisted microdiscectomy in adult patients undergoing single-level disc surgery. Methods: We prospectively compared the reherniation rate in 75 patients (Group 1) undergoing single-level lumbar disc surgery completed with the radiofrequency bipolar system Aquamantys® (Medtronic, Minneapolis, MN, USA) to that of a historical control group (n = 75) matched for variables related to herniation level and characteristics (Group 2). Patients were followed up to 4 years. Reherniations were assessed, pain and function were monitored throughout, and imaging was performed at annual follow-up. Results: The overall symptomatic reherniation rate was 4%. In particular, one case (1.3%) was observed in Group 1 and five (6.7%) in Group 2 (P < 0.05). Magnetic resonance imaging identified a total of 4 (2.7%) asymptomatic reherniations at 12 months, 6 (4%) at 24 and 36 months, and 7 (4.7%) at 48 months. Overall, Group 1 contained one (1.3%) asymptomatic reherniation case, while six (8%) were observed in Group 2 (P < 0.05). Conclusions: The low reherniation rate in patients treated by the coblation-assisted microdiscectomy suggests that this technique may reduce the reherniation risk. Clinical outcomes for pain and function at 4 years follow-up compared favorably with literature data. Randomized controlled trial could confirm these results. [ABSTRACT FROM AUTHOR]

During the 2007 ANtarctic geological DRILLing (ANDRILL) campaign in the Ross Sea, Antarctica, the AND‐2A core was recovered through a stratigraphic succession spanning 1,138.54 m of Neogene sedimentary rocks that include an expanded early to middle Miocene sequence. The study reported here focuses on the magnetic properties of the interval from 778.63 m below sea floor (mbsf) to 1,138.54 mbsf, which comprises a time interval spanning 1.5 Myr, from ~18.7 to ~20.2 Ma. We recognize three main pulses of increased input of magnetic materials to the drill site between 778.34–903.06, 950.55–995.78, and 1,040–1,103.96 mbsf. Trends in the magnetic mineral concentration dependent parameters mirror changes in the proportion of sediments derived from McMurdo Volcanic Group rocks. We suggest that these pulses in magnetic mineral concentration reflect changes in sediment transport processes associated with changing glacial conditions at the drill site that included (1) subglacial and grounding zone proximal settings, (2) hemipelagic and neritic conditions with abundant sediment‐rich icebergs, and (3) grounding zone‐distal environment that was covered by land‐fast multiyear sea ice or a fringing ice shelf. The magnetic minerals record preserved in the AND‐2A core supports other data that indicate a highly dynamic and variable coastal environment during the early Miocene, where glaciers retreated inland under warm climatic conditions and advanced beyond the drill site across the continental shelf when cold climate prevailed. Key Points: We investigate Miocene glacial dynamics recorded by variations in magnetic properties in the ANDRILL‐2A drill corePulses in magnetic mineral concentration reflect changes in sediment transport processes associated with changing glacial conditionsWe refine previous environmental interpretations and delineate a complex early Miocene paleoenvironment in the southern McMurdo Sound [ABSTRACT FROM AUTHOR]

This article explores the changes in migration strategies of Ecuadorian Kichwa-Otavalo indigenous merchants and musicians by following the accounts of three men of different ages. We address the ways strategies have transformed in three generations and the various types of relationships migrants establish in migration networks. In a scenario of both change and continuity in these strategies, which have seen Kichwa migration reach almost every continent in the world, we address the ways migration networks are connected in a transnational social field, which is dynamic and ever-changing. [ABSTRACT FROM AUTHOR]

The article presents an empirical investigation of the nature of financial crises in the U.S. in the pre-World War I era from 1880-1914 in an attempt to shed light on their characteristics and their generating mechanisms. In particular, the paper addresses questions of whether there are variables that reveal conditions conducive to crises, whether financial crises could be forecast, and whether they were alike, in the sense that a set of statistical relationships was common to all episodes. The author considers business cycles, stock market performance, changes in the deposit to currency ratio, interest rates, bubble theory, and the effect of bank panics on historic U.S. financial markets.