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Successful physician and administrator leader partnerships are a key differentiator in today's volatile, unpredictable, ever-changing health care landscape. Whether they are leading a division, a department, or an organization, intentional and mindful physician-administrator partnerships affect success from the micro individual level to the macro organizational level. Mayo Clinic's physician and administrative leaders are leveraging a long-held tradition of partnership by elevating their own competence as effective partners to ensure organizational sustainability. Specifically, physician and administrator leaders in the department of radiology have positioned collaboration at the foundation of their leadership practice, surrounded by the institutional values of respect, excellence, stewardship, and teamwork. From this framework, team leaders are better equipped and in a more stable position to prepare themselves and their colleagues for the very complex and unknown future., (Copyright © 2018 American College of Radiology. Published by Elsevier Inc. All rights reserved.)